Zobrazeno 1 - 4 of 4 pro vyhledávání: '"Mariam ElNaggar"'
1
Rapid multi‐attribute characterization of intact bispecific antibodies by a microfluidic chip‐based integrated icIEF‐MS technology
Autor: Maggie A. Ostrowski, Scott Mack, Milady Ninonuevo, John Yan, Mariam ElNaggar, Erik Gentalen, David A. Michels
Publikováno v: ELECTROPHORESIS. 44:378-386
Rapid, direct identification and quantitation of protein charge variants, and assessment of critical quality attributes with high sensitivity are important drivers required to accelerate the development of biotherapeutics. We describe the use of an e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4561554a52de6ab599e329af00ae583
https://doi.org/10.1002/elps.202200165
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2
Evaluation of an icIEF‐MS system for comparable charge variant analysis of biotherapeutics with rapid peak identification by mass spectrometry
Autor: Xiaoping He, Mariam ElNaggar, Maggie A. Ostrowski, Andras Guttman, Erik Gentalen, Justin Sperry
Publikováno v: ELECTROPHORESIS. 43:1215-1222
Protein therapeutics are usually produced in heterogeneous forms during bioproduction and bioprocessing. Heterogeneity results from post-translational modifications that can yield charge variants and require characterization throughout product develo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1d6224074a9931f79121e19e77fa15
https://doi.org/10.1002/elps.202100295
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