Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Marialuisa Menna"'
Publikováno v:
Molbank, Vol 2024, Iss 3, p M1882 (2024)
The one- or two-electron reduction in quinone compounds gives rise to semiquinones and hydroquinones, respectively, which, in turn, can be oxidized back to quinones, generating a cyclic redox system with the production of reactive oxygen species (ROS
Externí odkaz:
https://doaj.org/article/08b25067f6d04e71a8c0ad47e177490c
Autor:
Ayewa L. Agognon, Marcello Casertano, Alessio Vito, Sonia Orso, Serena Cabaro, Federica Mormone, Cristina Morelli, Giuseppe Perruolo, Pietro Formisano, Marialuisa Menna, Concetta Imperatore, Francesco Oriente
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6039 (2024)
Marine natural products constitute a great source of potential new antidiabetic drugs. The aim of this study was to evaluate the role of phosphoeleganin (PE), a polyketide purified from the Mediterranean ascidian Sidnyum elegans, and its derivatives
Externí odkaz:
https://doaj.org/article/781ce5e06962463fb8c9bfc3315bc281
Autor:
Marcello Casertano, Erika Esposito, Ivana Bello, Chiara Indolfi, Masteria Yunovilsa Putra, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Marialuisa Menna, Raffaella Sorrentino, Giuseppe Cirino, Roberta d’Emmanuele di Villa Bianca, Concetta Imperatore, Elisabetta Panza, Emma Mitidieri
Publikováno v:
Marine Drugs, Vol 21, Iss 12, p 641 (2023)
Hydrogen sulfide (H2S) is a signaling molecule endogenously produced within mammals’ cells that plays an important role in inflammation, exerting anti-inflammatory effects. In this view, the research has shown a growing interest in identifying natu
Externí odkaz:
https://doaj.org/article/50c1ccd3a51a4639adba20f80cec5b23
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2321 (2023)
Background: Type 2 diabetes mellitus (T2DM) is an ongoing, risky, and costly health problem that therefore always requires new treatment options. Moreover, although several drugs are available, only 36% of patients achieve glycaemic control, and pati
Externí odkaz:
https://doaj.org/article/e3485d7417614223a2d5100ec72c119f
Autor:
Marcello Casertano, Massimo Genovese, Alice Santi, Erica Pranzini, Francesco Balestri, Lucia Piazza, Antonella Del Corso, Sibel Avunduk, Concetta Imperatore, Marialuisa Menna, Paolo Paoli
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 528 (2023)
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by impaired glucose homeostasis and serious long-term complications. First-line therapeutic options for T2DM treatment are monodrug therapies, often replaced by multidrug therapies to
Externí odkaz:
https://doaj.org/article/5273a03c95cc44c588a6ba126200aae1
Autor:
Marcello Casertano, Massimo Genovese, Lucia Piazza, Francesco Balestri, Antonella Del Corso, Alessio Vito, Paolo Paoli, Alice Santi, Concetta Imperatore, Marialuisa Menna
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 325 (2022)
Diabetes mellitus (DM) represents a complex and multifactorial disease that causes metabolic disorders with acute and long-term serious complications. The onset of DM, with over 90% of cases of diabetes classified as type 2, implies several metabolic
Externí odkaz:
https://doaj.org/article/4e23780dcc09471b819e3abee06f0a23
Autor:
Rosa Bellavita, Marcello Casertano, Nicola Grasso, Malachi Gillick-Healy, Brian G. Kelly, Mauro F. A. Adamo, Marialuisa Menna, Francesco Merlino, Paolo Grieco
Publikováno v:
Symmetry, Vol 14, Iss 3, p 435 (2022)
Indole moiety is well-known as a superlative framework in many natural products and synthetic pharmaceuticals. Herein, we report an efficient procedure to synthesize a series of functionalized 2-methyl-1H-indole-3-carboxylate derivatives from commerc
Externí odkaz:
https://doaj.org/article/6e00306a697b46ffb3827b2fa4e4392e
Autor:
Marcello Casertano, Massimo Genovese, Paolo Paoli, Alice Santi, Anna Aiello, Marialuisa Menna, Concetta Imperatore
Publikováno v:
Marine Drugs, Vol 20, Iss 1, p 65 (2022)
The chemical investigation of the Mediterranean ascidian Clavelina lepadiformis has led to the isolation of a new lepadin, named lepadin L, and two known metabolites belonging to the same family, lepadins A and B. The planar structure and relative co
Externí odkaz:
https://doaj.org/article/90b06df09c79446cb2f961f6505459ad
Autor:
Massimo Genovese, Concetta Imperatore, Marcello Casertano, Anna Aiello, Francesco Balestri, Lucia Piazza, Marialuisa Menna, Antonella Del Corso, Paolo Paoli
Publikováno v:
Marine Drugs, Vol 19, Iss 10, p 535 (2021)
An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AR) enzymes, including analysis of the insulin signalling pathway, of phosphoeleganin, a marine-derived phosphorylated polyketide, was achi
Externí odkaz:
https://doaj.org/article/25ac514a0cc94604881f5b4820ca97e7
Autor:
Concetta Imperatore, Antonio Varriale, Elisa Rivieccio, Angela Pennacchio, Maria Staiano, Sabato D’Auria, Marcello Casertano, Carlo Altucci, Mohammadhassan Valadan, Manjot Singh, Marialuisa Menna, Michela Varra
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7103 (2020)
The synthesis of two 5′-end (4-dimethylamino)azobenzene conjugated G-quadruplex forming aptamers, the thrombin binding aptamer (TBA) and the HIV-1 integrase aptamer (T30695), was performed. Their structural behavior was investigated by means of UV,
Externí odkaz:
https://doaj.org/article/3ce2db96151c420b9e1be5b1dcfd7ca0