Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Marialuigia Fantacuzzi"'
Autor:
Marialuigia Fantacuzzi, Ilaria D’Agostino, Simone Carradori, Francesco Liguori, Fabrizio Carta, Mariangela Agamennone, Andrea Angeli, Filomena Sannio, Jean-Denis Docquier, Clemente Capasso, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Vibrio cholerae causes life-threatening infections in low-income countries due to the rise of antibacterial resistance. Innovative pharmacological targets have been investigated and carbonic anhydrases (CAs, EC: 4.2.1.1) encoded by V. cholerae (VchCA
Externí odkaz:
https://doaj.org/article/2b2ee7385c74438ea7ee86320973175f
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 404 (2024)
In recent years, continuous progress has been made in the development of new anticancer drugs, and several compounds (small molecules, engineered antibodies, immunomodulators, etc [...]
Externí odkaz:
https://doaj.org/article/0b6e8998db144088b8c178aa4d7a5662
Publikováno v:
Pharmaceuticals, Vol 17, Iss 3, p 316 (2024)
Immunotherapy has marked a revolution in cancer therapy. The most extensively studied target in this field is represented by the protein–protein interaction between PD-1 and its ligand, PD-L1. The promising results obtained with the clinical use of
Externí odkaz:
https://doaj.org/article/85c9340c6abc4e8fb8d7d8c9ed775794
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16507 (2023)
Nature has always been a precious source of bioactive molecules which are used for the treatment of various diseases [...]
Externí odkaz:
https://doaj.org/article/1532b0e0efc4416f9ead00912a440cf7
Autor:
Cristina Maccallini, Marialucia Gallorini, Francesca Sisto, Atilla Akdemir, Alessandra Ammazzalorso, Barbara De Filippis, Marialuigia Fantacuzzi, Letizia Giampietro, Simone Carradori, Amelia Cataldi, Rosa Amoroso
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1631-1644 (2021)
Nonsteroidal aromatase inhibitors (NSAIs) are well-established drugs for the therapy of breast cancer. However, they display some serious side effects, and their efficacy can be compromised by the development of chemoresistance. Previously, we have r
Externí odkaz:
https://doaj.org/article/a43700700f7c42c78f6d64d8089ba481
Autor:
Simone Carradori, Marialuigia Fantacuzzi, Alessandra Ammazzalorso, Andrea Angeli, Barbara De Filippis, Salvatore Galati, Anél Petzer, Jacobus P. Petzer, Giulio Poli, Tiziano Tuccinardi, Mariangela Agamennone, Claudiu T. Supuran
Publikováno v:
Molecules, Vol 27, Iss 22, p 7816 (2022)
Neurodegenerative diseases (NDs) are described as multifactorial and progressive syndromes with compromised cognitive and behavioral functions. The multi-target-directed ligand (MTDL) strategy is a promising paradigm in drug discovery, potentially le
Externí odkaz:
https://doaj.org/article/eca94da8116e44cf84aec1c9c2fcb8df
Autor:
Mariangela Agamennone, Marialuigia Fantacuzzi, Simone Carradori, Anél Petzer, Jacobus P. Petzer, Andrea Angeli, Claudiu T. Supuran, Grazia Luisi
Publikováno v:
Molecules, Vol 27, Iss 22, p 7884 (2022)
The involvement of human carbonic anhydrase (hCA) IX/XII in the pathogenesis and progression of many types of cancer is well acknowledged, and more recently human monoamine oxidases (hMAOs) A and B have been found important contributors to tumor deve
Externí odkaz:
https://doaj.org/article/7a8ead5bfc0a4db29dc3a0944120e71c
Autor:
Mariangela Agamennone, Marialuigia Fantacuzzi, Giovanni Vivenzio, Maria Carmina Scala, Pietro Campiglia, Fabiana Superti, Marina Sala
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11433 (2022)
Influenza viruses represent a leading cause of high morbidity and mortality worldwide. Approaches for fighting flu are seasonal vaccines and some antiviral drugs. The development of the seasonal flu vaccine requires a great deal of effort, as careful
Externí odkaz:
https://doaj.org/article/4991a0edface4ac0b811664ebcf04b8c
Autor:
Alessandra Ammazzalorso, Simone Carradori, Andrea Angeli, Atilla Akdemir, Barbara De Filippis, Marialuigia Fantacuzzi, Letizia Giampietro, Cristina Maccallini, Rosa Amoroso, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1051-1061 (2019)
A large library of fibrate-based N-acylsulphonamides was designed, synthesised, and fully characterised in order to propose them as zinc binders for the inhibition of human carbonic anhydrase (hCA) enzymatic activity. Synthesised compounds were teste
Externí odkaz:
https://doaj.org/article/c164fee9eb5e4e1c8e672e3359f039df
Publikováno v:
Molecules, Vol 27, Iss 14, p 4650 (2022)
Cancer is a multifactorial disorder caused by several aberrations in gene expression that generate a homeostatic imbalance between cell division and death [...]
Externí odkaz:
https://doaj.org/article/9433f5dbdf6a47e8b2ffd049e4120551