Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Marialaura, Amadio"'
Autor:
Giorgia Bresciani, Federico Manai, Szabolcs Felszeghy, Adrian Smedowski, Kai Kaarniranta, Marialaura Amadio
Publikováno v:
Pharmacological Research, Vol 208, Iss , Pp 107380- (2024)
Age-related macular degeneration (AMD) is a common retinal pathology characterized by degeneration of macula’s retinal pigment epithelium (RPE) and photoreceptors, visual impairment, or loss. Compared to wet AMD, dry AMD is more common, but lacks c
Externí odkaz:
https://doaj.org/article/0f9add5665b3456fb9ac26de4269b080
Autor:
Giorgia Bresciani, Federico Manai, Sergio Davinelli, Paolo Tucci, Luciano Saso, Marialaura Amadio
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Dimethyl fumarate (DMF) is an FDA-approved drug for the treatment of psoriasis and multiple sclerosis. DMF is known to stabilize the transcription factor Nrf2, which in turn induces the expression of antioxidant response element genes. It has also be
Externí odkaz:
https://doaj.org/article/3d8355aa847b41d6bfa673adb970b0e0
Autor:
Anna Pacwa, Joanna Machowicz, Saeed Akhtar, Piotr Rodak, Xiaonan Liu, Marita Pietrucha-Dutczak, Joanna Lewin-Kowalik, Marialaura Amadio, Adrian Smedowski
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionELAVL1/HuR is a keystone regulator of gene expression at the posttranscriptional level, including stress response and homeostasis maintenance. The aim of this study was to evaluate the impact of hur silencing on the age-related degenerati
Externí odkaz:
https://doaj.org/article/692ea11028b84e33a06c01d2f608a64f
Publikováno v:
Cells, Vol 11, Iss 24, p 4061 (2022)
Dimethyl fumarate (DMF) is a small molecule currently approved and used in the treatment of psoriasis and multiple sclerosis due to its immuno-modulatory, anti-inflammatory, and antioxidant properties. As an Nrf2 activator through Keap1 protein inhib
Externí odkaz:
https://doaj.org/article/c19a7fa6a4b840ceb5bb418ed5c8bc6f
Autor:
Szabolcs Felszeghy, Johanna Viiri, Jussi J. Paterno, Juha M.T. Hyttinen, Ali Koskela, Mei Chen, Henri Leinonen, Heikki Tanila, Niko Kivinen, Arto Koistinen, Elisa Toropainen, Marialaura Amadio, Adrian Smedowski, Mika Reinisalo, Mateusz Winiarczyk, Jerzy Mackiewicz, Maija Mutikainen, Anna-Kaisa Ruotsalainen, Mikko Kettunen, Kimmo Jokivarsi, Debasish Sinha, Kati Kinnunen, Goran Petrovski, Janusz Blasiak, Geir Bjørkøy, Ari Koskelainen, Heli Skottman, Arto Urtti, Antero Salminen, Ram Kannan, Deborah A. Ferrington, Heping Xu, Anna-Liisa Levonen, Pasi Tavi, Anu Kauppinen, Kai Kaarniranta
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 1-12 (2019)
Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irreversible and severe vision loss in the developed countries. It has been suggested that the pathogenesis of dry AMD involves impaired protein degradat
Externí odkaz:
https://doaj.org/article/623c13f35ca24a70a5117e36da09403d
Autor:
Federico Manai, Marialaura Amadio
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1924 (2022)
Dimethyl fumarate (DMF) is a well-known activator of Nrf2 (NF-E2-related factor 2), used in the treatment of psoriasis and multiple sclerosis. The mechanism of action consists in the modification of the cysteine residues on the Nrf2-inhibitor Keap1,
Externí odkaz:
https://doaj.org/article/d67e3b7611db452d9446c43f5830f1a5
Autor:
Ali Koskela, Federico Manai, Filippo Basagni, Mikko Liukkonen, Michela Rosini, Stefano Govoni, Massimo Dal Monte, Adrian Smedowski, Kai Kaarniranta, Marialaura Amadio
Publikováno v:
Antioxidants, Vol 11, Iss 7, p 1385 (2022)
Antioxidant systems play key roles in many elderly diseases, including age-related macular degeneration (AMD). Oxidative stress, autophagy impairment and inflammation are well-described in AMD, especially in retinal pigment epithelial (RPE) cells. Th
Externí odkaz:
https://doaj.org/article/46e1e026e781474b986447754fb1bd4d
Autor:
Francesca Fagiani, Michele Catanzaro, Erica Buoso, Filippo Basagni, Daniele Di Marino, Stefano Raniolo, Marialaura Amadio, Eric H. Frost, Emanuela Corsini, Marco Racchi, Tamas Fulop, Stefano Govoni, Michela Rosini, Cristina Lanni
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The transcription factor Nrf2 coordinates a multifaceted response to various forms of stress and to inflammatory processes, maintaining a homeostatic intracellular environment. Nrf2 anti-inflammatory activity has been related to the crosstalk with th
Externí odkaz:
https://doaj.org/article/4b7dc9e5773142e4a45a0d02ec68629f
Autor:
Michele Catanzaro, Cristina Lanni, Filippo Basagni, Michela Rosini, Stefano Govoni, Marialaura Amadio
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Age-related macular degeneration (AMD) is a common disease with a multifactorial aetiology, still lacking effective and curative therapies. Among the early events triggering AMD is the deterioration of the retinal pigment epithelium (RPE), whose fund
Externí odkaz:
https://doaj.org/article/f4488813646d4e78ba5b6109cf6efc9e
Autor:
Maria Grazia Rossino, Rosario Amato, Marialaura Amadio, Michela Rosini, Filippo Basagni, Maurizio Cammalleri, Massimo Dal Monte, Giovanni Casini
Publikováno v:
Antioxidants, Vol 10, Iss 8, p 1296 (2021)
Oxidative stress (OS) plays a key role in retinal dysfunctions and acts as a major trigger of inflammatory and neurodegenerative processes in several retinal diseases. To prevent OS-induced retinal damage, approaches based on the use of natural compo
Externí odkaz:
https://doaj.org/article/fbaafcc3263c42c4bfe611bb5dcf9a28