Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mariah C. Marcondes"'
Autor:
Mariah C Marcondes, Anne C S Fernandes, Ivaldo Itabaiana, Rodrigo O M A de Souza, Mauro Sola-Penna, Patricia Zancan
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130555 (2015)
Although demonstrated as a selective anticancer drug, the clinical use of clotrimazole (CTZ) is limited due to its low solubility in hydrophilic fluids. Thus, we prepared a water-soluble nanomicellar formulation of CTZ (nCTZ) and tested on the human
Externí odkaz:
https://doaj.org/article/3c6d326bba2e4a5497fb41f4c5de0ce0
Autor:
Mariah C. Marcondes, Cláudia P. Figueiredo, Jessica R. Branco, Alan C. Ochioni, Mauro Sola-Penna, Wagner Santos Coelho, Daniela Baptista-de-Souza, Larissa Pereira Paixão, Patricia Zancan, Davi M. Mundim, Jamille Mansur Albanese
Publikováno v:
British Journal of Cancer
Background Although produced by several types of tumours, the role of serotonin on cancer biology is yet to be understood. Methods The effects of serotonin (5-HT) on human breast cancer cells proliferation, signalling pathways and metabolic profile w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d1f17860fa27ea1b29c85bfe695160
https://doi.org/10.1038/s41416-019-0640-1
https://doi.org/10.1038/s41416-019-0640-1
Autor:
Cristiane M Furtado, Mariah C Marcondes, Mauro Sola-Penna, Maisa L S de Souza, Patricia Zancan
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30462 (2012)
BACKGROUND: Clotrimazole is an azole derivative with promising anti-cancer effects. This drug interferes with the activity of glycolytic enzymes altering their cellular distribution and inhibiting their activities. The aim of the present study was to
Externí odkaz:
https://doaj.org/article/3198f0b696b24c5c8ba2e8840d1b742f
Autor:
Julia Rios Carvalho, Mariah C. Marcondes, Mauro Sola-Penna, Sônia Soares Costa, Patricia Zancan, Renan da Silva Gianoti Torres, Livia Marques Casanova
Publikováno v:
Journal of Bioenergetics and Biomembranes. 50:93-105
Breast cancer is the major cause of death by cancer in women worldwide and in spite of the many drugs for its treatment, there is still the need for novel therapies for its control. Ocimum species have been used by traditional medicine to control sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb48157086eb20b481e05ecbd3bd21c2
https://doi.org/10.1007/s10863-018-9750-3
https://doi.org/10.1007/s10863-018-9750-3
Autor:
Renato S. Carvalho, Mauro Sola-Penna, Patricia Zancan, Cristiane M. Furtado, Mariah C. Marcondes
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 62:132-141
Clotrimazole (CTZ) has been proposed as an antitumoral agent because of its properties that inhibit glycolytic enzymes and detach them from the cytoskeleton. However, the broad effects of the drug, e.g., acting on different enzymes and pathways, indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fd5d4360d9d85f4afb31c932c6f47f
https://doi.org/10.1016/j.biocel.2015.03.004
https://doi.org/10.1016/j.biocel.2015.03.004
Autor:
Sônia Soares Costa, Patricia Zancan, Larissa Pereira Paixão, Livia Marques Casanova, Jair Machado Espindola-Netto, Mariah C. Marcondes, Mauro Sola-Penna, Giany O. De Melo, Daniel Passos da Silva
Publikováno v:
IUBMB Life. 66:361-370
The aim of this study was to evaluate the antidiabetic potential of a leaf extract and flavonoids from Sedum dendroideum (SD). Additionally, our goals were to establish a possible structure/activity relationship between these flavonoids and to assess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::721acca1472a9d57e33dfcbe1b05e011
https://doi.org/10.1002/iub.1270
https://doi.org/10.1002/iub.1270
Autor:
José Roberto Meyer-Fernandes, Lilian S. Gomez, Daniel Passos da Silva, Mariah C. Marcondes, Mauro Sola-Penna, Patricia Zancan, Livia Ramos-Santos
Publikováno v:
Biochimie. 95(6):1336-1343
Cancer cells are highly dependent on glycolysis to supply the energy and intermediates required for cell growth and proliferation. The enzyme 6-phosphofructo-1-kinase (PFK) is critical for glycolysis, and its activity is directly correlated with cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751a87ce905485cc121225e1272b45fc
Publikováno v:
IUBMB Life. 63:435-445
6-Phosphofructo-1-kinase (PFK) and aldolase are two sequential glycolytic enzymes that associate forming heterotetramers containing a dimer of each enzyme. Although free PFK dimers present a negligible activity, once associated to aldolase these dime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7972a18d858a7a9c7465ff50ad9f3e2
https://doi.org/10.1002/iub.464
https://doi.org/10.1002/iub.464
Autor:
Mauro Sola-Penna, Monica M. Marinho-Carvalho, Patricia Zancan, Alicia O. Rosas, Mariah C. Marcondes
Publikováno v:
Biochemical Pharmacology. 73:1520-1527
Clotrimazole is an antifungal azole derivative recently recognized as a calmodulin antagonist with promising anticancer effects. This property has been correlated with the ability of the drug to decrease the viability of tumor cells by inhibiting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23daa1b12a4733918c3bfeb1d0760d6e
https://doi.org/10.1016/j.bcp.2007.01.018
https://doi.org/10.1016/j.bcp.2007.01.018
Autor:
Patricia Zancan, Mariah C. Marcondes, Anne C. S. Fernandes, Mauro Sola-Penna, Rodrigo O. M. A. de Souza, Ivaldo Itabaiana
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0130555 (2015)
PLoS ONE, Vol 10, Iss 6, p e0130555 (2015)
Background Although demonstrated as a selective anticancer drug, the clinical use of clotrimazole (CTZ) is limited due to its low solubility in hydrophilic fluids. Thus, we prepared a water-soluble nanomicellar formulation of CTZ (nCTZ) and tested on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b496092d1a27914ca8b77173e74adc61
https://pubmed.ncbi.nlm.nih.gov/26098874
https://pubmed.ncbi.nlm.nih.gov/26098874