Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mariagrazia Garramone"'
Autor:
Francesca Salani, Valentina Sterbini, Eleonora Sacchinelli, Mariagrazia Garramone, Paola Bossù
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
An emergent concept in immunology suggests that innate immune system is capable to undergo non-specific long-term responses and to provide resistance by modifying the reactivity to sequential pathogen challenge. This phenomenon, named innate memory,
Externí odkaz:
https://doaj.org/article/bd6bf68bee2448d6acad3e77c43d3541
Autor:
Matteo Carrabba, Fabio Ciceri, Marica Eoli, Gaetano Finocchiaro, Andrew Zambanini, Stefania Mazzoleni, Alessia Capotondo, Bianca Pollo, Bernhard Gentner, Maria Grazia Bruzzone, Francesco DiMeco, Federico G. Legnani, Mariagrazia Garramone, Paolo Ferroli, Stefania Girlanda, Valeria Cuccarini, Luigi Naldini, Rosina Paterra, Farina Francesca, Carlo Russo, Elena Anghileri, Marco Saini
Publikováno v:
Neuro Oncol
GBM with an unmethylated MGMT gene promoter is associated with very poor prognosis. A subset of tumor associated macrophages expressing the angiopoietin receptor Tie2 (TEMs) can be genetically modified for local & tumor restricted release of interfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c791444f30ce87b8101f48d125a66f
https://europepmc.org/articles/PMC7650474/
https://europepmc.org/articles/PMC7650474/
Autor:
Bernhard Gentner, Filippo Gagliardi, Gabriele Antonarelli, Bianca Pollo, Maria Grazia Bruzzone, Monica Patanè, Elena Anghileri, Stefania Mazzoleni, Fabio Ciceri, Marica Eoli, Valentina Brambilla, Capotondo Alessia, Silvia Snider, Carlo Russo, Matteo Maria Naldini, Valeria Ferla, Matteo Carrabba, Rosina Paterra, Giorgio D'Alessandris, Alessandro Olivi, Zahid Bashir, Matteo Barcella, Luigi Naldini, Valeria Cuccarini, Marco Saini, Roberto Pallini, Francesco Di Meco, Francesca Farina, Paolo Ferroli, Federico G. Legnani, Mariagrazia Garramone, G. Finocchiaro, Tiziana Magnani, Pietro Mortini
Publikováno v:
Blood. 138:2844-2844
Background: We developed a macrophage-based treatment relying on ex vivo transduction of autologous hematopoietic stem and progenitor cells (HSPC) to express immune-payloads within the TME. Our ATMP (Temferon) targets IFN-a, an immune-modulatory mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab0f8cb9b7cbb3234eca5ae3e40f901c
https://doi.org/10.1182/blood-2021-150230
https://doi.org/10.1182/blood-2021-150230
Autor:
Alessia Capotondo, Stefania Mazzoleni, Alessandro Olivi, Paolo Ferroli, Rosina Paterra, Bernhard Gentner, Matteo Barcella, Farina Francesca, G. Finocchiaro, Giorgio D'Alessandris, Zahid Bashir, Federico G. Legnani, Mariagrazia Garramone, Valentina Brambilla, Valeria Ferla, Monica Patanè, Valeria Cuccarini, Gabriele Antonarelli, Matteo Carrabba, Bianca Pollo, Matteo Maria Naldini, Luigi Naldini, Mariagrazia Bruzzone, Eoli Marica, Fabio Ciceri, Marco Saini, Tiziana Magnani, Carlo Russo, Roberto Pallini, Francesco Di Meco
Publikováno v:
Neuro Oncol
Temferon is an ex vivo gene therapy consisting of autologous HSPCs genetically modified to deliver IFN-α2 within the tumor microenvironment (TME) by Tie-2 expressing macrophages. TEM-GBM is an open-label, Phase I/IIa dose-escalation study evaluating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1a76c929ecd1be607821d4db2c5ae9
https://doi.org/10.1093/neuonc/noab196.211
https://doi.org/10.1093/neuonc/noab196.211
Autor:
Matteo Carrabba, Quintino Giorgio D'Alessandris, Monica Patanè, Federico G. Legnani, Valentina Brambilla, Stefania Mazzoleni, Mariagrazia Garramone, Silvia Snider, Luigi Naldini, Marica Eoli, Roberto Pallini, Matteo Barcella, Matteo Maria Naldini, Valeria Cuccarini, Paolo Ferroli, Fabio Ciceri, Francesca Farina, Elena Anghileri, Zahid Bashir, Bianca Pollo, Tiziana Magnani, G. Finocchiaro, Marco Saini, Alessia Capotondo, Bernhard Gentner, Francesco DiMeco, Alessandro Olivi, Gabriele Antonarelli, Rosina Paterra, Piero Mortini, Carlo Russo, Valeria Ferla, Filippo Gagliardi, Maria Grazia Bruzzone
Publikováno v:
Neuro-Oncology Advances. 3:iv4-iv4
Temferon is a macrophage-based treatment relying on ex-vivo transduction of autologous HSPCs to express immune-payloads within the TME. Temferon targets the immune-modulatory molecule IFN-a, to a subset of tumor infiltrating macrophages known as Tie-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b0b1b355601af50dff5af7ec111242a
https://doi.org/10.1093/noajnl/vdab112.014
https://doi.org/10.1093/noajnl/vdab112.014
Autor:
Mariagrazia Garramone, Valentina Sterbini, Francesca Salani, Paola Bossù, Eleonora Sacchinelli
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology
An emergent concept in immunology suggests that innate immune system is capable to undergo non-specific long-term responses and to provide resistance by modifying the reactivity to sequential pathogen challenge. This phenomenon, named innate memory,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9652c95083e354e22277793c087ac3
https://pubmed.ncbi.nlm.nih.gov/31440234
https://pubmed.ncbi.nlm.nih.gov/31440234