Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Mariaelena, Pierobon"'
Autor:
Claire E. Blanchard, Alison T. Gomeiz, Kyle Avery, Emna El Gazzah, Abduljalil M. Alsubaie, Masoumeh Sikaroodi, Ylenia Chiari, Chelsea Ward, Jonathan Sanchez, Virginia Espina, Emanuel Petricoin, Elisa Baldelli, Mariaelena Pierobon
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Tumor heterogeneity is a main contributor of resistance to anti-cancer targeted agents though it has proven difficult to study. Unfortunately, model systems to functionally characterize and mechanistically study dynamic responses
Externí odkaz:
https://doaj.org/article/c5d264218ccf46bbb36670695390a8aa
Autor:
Daniel P. Nussbaum, Colin A. Martz, Andrew M. Waters, Alejandro Barrera, Annie Liu, Justine C. Rutter, Christian G. Cerda-Smith, Amy E. Stewart, Chao Wu, Merve Cakir, Cecilia B. Levandowski, David E. Kantrowitz, Shannon J. McCall, Mariaelena Pierobon, Emanuel F. Petricoin, J. Joshua Smith, Timothy E. Reddy, Channing J. Der, Dylan J. Taatjes, Kris C. Wood
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produc
Externí odkaz:
https://doaj.org/article/f640317b562445dfa0b4f3772b68e0d1
Autor:
Nicholas W. Bateman, Tamara Abulez, Anthony R. Soltis, Andrew McPherson, Seongmin Choi, Dale W. Garsed, Ahwan Pandey, Chunqiao Tian, Brian L. Hood, Kelly A. Conrads, Pang-ning Teng, Julie Oliver, Glenn Gist, Dave Mitchell, Tracy J. Litzi, Christopher M. Tarney, Barbara A. Crothers, Paulette Mhawech-Fauceglia, Clifton L. Dalgard, Matthew D. Wilkerson, Mariaelena Pierobon, Emanuel F. Petricoin, Chunhua Yan, Daoud Meerzaman, Clara Bodelon, Nicolas Wentzensen, Jerry S. H. Lee, The APOLLO Research Network, David G. Huntsman, Sohrab Shah, Craig D. Shriver, Neil T. Phippen, Kathleen M. Darcy, David D. L. Bowtell, Thomas P. Conrads, G. Larry Maxwell
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-17 (2024)
Abstract We performed a deep proteogenomic analysis of bulk tumor and laser microdissection enriched tumor cell populations from high-grade serous ovarian cancer (HGSOC) tissue specimens spanning a broad spectrum of purity. We identified patients wit
Externí odkaz:
https://doaj.org/article/24fb205468404dc8816ab7d41beb50e4
Autor:
Page E. Blas, Esther San Roman Rodriguez, Heather L. Williams, Maren K. Levin, Joshua S. K. Bell, Mariaelena Pierobon, Alexander S. Barrett, Emanuel F. Petricoin, Joyce A. O'Shaughnessy
Publikováno v:
Cancer Reports, Vol 7, Iss 3, Pp n/a-n/a (2024)
Abstract Background Overexpression of HER2 plays an important role in cancer progression and is the target of multiple therapies in HER2‐positive breast cancer. Recent studies have also highlighted the presence of activating mutations in HER2, and
Externí odkaz:
https://doaj.org/article/47960155bf034b2787b9b2901ca8c6f8
Autor:
Nicholas W. Bateman, Tamara Abulez, Anthony R. Soltis, Andrew McPherson, Seongmin Choi, Dale W. Garsed, Ahwan Pandey, Chunqiao Tian, Brian L. Hood, Kelly A. Conrads, Pang-ning Teng, Julie Oliver, Glenn Gist, Dave Mitchell, Tracy J. Litzi, Christopher M. Tarney, Barbara A. Crothers, Paulette Mhawech-Fauceglia, Clifton L. Dalgard, Matthew D. Wilkerson, Mariaelena Pierobon, Emanuel F. Petricoin, Chunhua Yan, Daoud Meerzaman, Clara Bodelon, Nicolas Wentzensen, Jerry S. H. Lee, The APOLLO Research Network, David G. Huntsman, Sohrab Shah, Craig D. Shriver, Neil T. Phippen, Kathleen M. Darcy, David D. L. Bowtell, Thomas P. Conrads, G. Larry Maxwell
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/0fd6d7e0522640fb848fd7d8ca72ab88
Autor:
Maysa M. Abu-Khalaf, K. Alex Hodge, Christos Hatzis, Elisa Baldelli, Emna El Gazzah, Frances Valdes, William M. Sikov, Monica M. Mita, Neelima Denduluri, Rita Murphy, Daniel Zelterman, Lance Liotta, Bryant Dunetz, Rick Dunetz, Emanuel F. Petricoin, Mariaelena Pierobon
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract Endocrine therapy (ET) in combination with CDK4/6 inhibition is routinely used as first-line treatment for HR+/HER2− metastatic breast cancer (MBC) patients. However, 30–40% of patients quickly develop disease progression. In this open-l
Externí odkaz:
https://doaj.org/article/c34fa79216b44a448f600ad8e158ac17
Autor:
Mariaelena Pierobon, Nicholas J. Robert, Donald W. Northfelt, Mohammad Jahanzeb, Shukmei Wong, Kimberly A. Hodge, Elisa Baldelli, Jessica Aldrich, David W. Craig, Lance A. Liotta, Sanja Avramovic, Janusz Wojtusiak, Farrokh Alemi, Julia D. Wulfkuhle, Angela Bellos, Rosa I. Gallagher, David Arguello, Amber Conrad, Ariane Kemkes, David M. Loesch, Linda Vocila, Bryant Dunetz, John D. Carpten, Emanuel F. Petricoin, Stephen P. Anthony
Publikováno v:
Molecular Oncology, Vol 16, Iss 1, Pp 104-115 (2022)
This prospective phase II clinical trial (Side Out 2) explored the clinical benefits of treatment selection informed by multi‐omic molecular profiling (MoMP) in refractory metastatic breast cancers (MBCs). Core needle biopsies were collected from 3
Externí odkaz:
https://doaj.org/article/a34e1099108d4ecd8b5fb3cad6ddfdec
Autor:
Özgün Le Roux, Nicole LK Pershing, Erin Kaltenbrun, Nicole J Newman, Jeffrey I Everitt, Elisa Baldelli, Mariaelena Pierobon, Emanuel F Petricoin, Christopher M Counter
Publikováno v:
eLife, Vol 11 (2022)
Despite multiple possible oncogenic mutations in the proto-oncogene KRAS, unique subsets of these mutations are detected in different cancer types. As KRAS mutations occur early, if not being the initiating event, these mutational biases are ostensib
Externí odkaz:
https://doaj.org/article/dd9835a4ba684963a09df745f1a58e3a
Publikováno v:
Bioengineering, Vol 10, Iss 6, p 690 (2023)
Artificial intelligence and emerging data science techniques are being leveraged to interpret medical image scans. Traditional image analysis relies on visual interpretation by a trained radiologist, which is time-consuming and can, to some degree, b
Externí odkaz:
https://doaj.org/article/3de7698cbf8b4e9db20f0c60fe430c40
Autor:
Marta Codrich, Emiliano Dalla, Catia Mio, Giulia Antoniali, Matilde Clarissa Malfatti, Stefania Marzinotto, Mariaelena Pierobon, Elisa Baldelli, Carla Di Loreto, Giuseppe Damante, Giovanni Terrosu, Carlo Ennio Michele Pucillo, Gianluca Tell
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-17 (2021)
Abstract Background Colorectal cancer (CRC) represents the fourth leading cause of cancer-related deaths. The heterogeneity of CRC identity limits the usage of cell lines to study this type of tumor because of the limited representation of multiple f
Externí odkaz:
https://doaj.org/article/6e0b3cedf67c401c84c334288fd77d63