Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mariacarmela Allocca"'
Autor:
Moritz J. Schmidt, Ashish Gupta, Christien Bednarski, Stefanie Gehrig-Giannini, Florian Richter, Christian Pitzler, Michael Gamalinda, Christina Galonska, Ryo Takeuchi, Kui Wang, Caroline Reiss, Kerstin Dehne, Michael J. Lukason, Akiko Noma, Cindy Park-Windhol, Mariacarmela Allocca, Albena Kantardzhieva, Shailendra Sane, Karolina Kosakowska, Brian Cafferty, Jan Tebbe, Sarah J. Spencer, Scott Munzer, Christopher J. Cheng, Abraham Scaria, Andrew M. Scharenberg, André Cohnen, Wayne M. Coco
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/ea3084e9d59245a1998e55dd20e1cb3d
Autor:
Moritz J. Schmidt, Ashish Gupta, Christien Bednarski, Stefanie Gehrig-Giannini, Florian Richter, Christian Pitzler, Michael Gamalinda, Christina Galonska, Ryo Takeuchi, Kui Wang, Caroline Reiss, Kerstin Dehne, Michael J. Lukason, Akiko Noma, Cindy Park-Windhol, Mariacarmela Allocca, Albena Kantardzhieva, Shailendra Sane, Karolina Kosakowska, Brian Cafferty, Jan Tebbe, Sarah J. Spencer, Scott Munzer, Christopher J. Cheng, Abraham Scaria, Andrew M. Scharenberg, André Cohnen, Wayne M. Coco
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Abstract Streptococcus pyogenes (Spy) Cas9 has potential as a component of gene therapeutics for incurable diseases. One of its limitations is its large size, which impedes its formulation and delivery in therapeutic applications. Smaller Cas9s are a
Externí odkaz:
https://doaj.org/article/164ce27f7fcc420f8085cc9624163a4b
Autor:
Marianthi Karali, Anna Manfredi, Agostina Puppo, Elena Marrocco, Annagiusi Gargiulo, Mariacarmela Allocca, Michele Della Corte, Settimio Rossi, Massimo Giunti, Maria Laura Bacci, Francesca Simonelli, Enrico Maria Surace, Sandro Banfi, Alberto Auricchio
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22166 (2011)
Gene transfer using adeno-associated viral (AAV) vectors has been successfully applied in the retina for the treatment of inherited retinal dystrophies. Recently, microRNAs have been exploited to fine-tune transgene expression improving therapeutic o
Externí odkaz:
https://doaj.org/article/79abea0e1e234d61af25c15dacb3dc74
Autor:
Jan Tebbe, Florian Richter, Sarah J. Spencer, Karolina A. Kosakowska, Wayne Coco, Christien Bednarski, Cindy Park-Windhol, Abraham Scaria, Michael Biag Gamalinda, Ryo Takeuchi, Scott Munzer, Akiko Noma, Albena Kantardzhieva, Andre Cohnen, Michael Lukason, Mariacarmela Allocca, Caroline W. Reiss, Andrew M. Scharenberg, Brian J. Cafferty, Christian Pitzler, Stefanie Gehrig-Giannini, Kui Wang, Ashish Gupta, Kerstin Dehne, Sane Shailendra, Christina Galonska, Moritz Schmidt, Christopher J. Cheng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
Streptococcus pyogenes (Spy) Cas9 has potential as a component of gene therapeutics for incurable diseases. One of its limitations is its large size, which impedes its formulation and delivery in therapeutic applications. Smaller Cas9s are an alterna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5691833fda2217e508f7975cce09f1c3
https://doi.org/10.1038/s41467-021-24454-5
https://doi.org/10.1038/s41467-021-24454-5
Autor:
Jennifer A. Calvo, Kimberly R. Fake, Joshua J. Corrigan, Leona D. Samson, Mariacarmela Allocca
Publikováno v:
Oncotarget
// Mariacarmela Allocca 1, 3 , Joshua J. Corrigan 1, 3 , Kimberly R. Fake 1, 3 , Jennifer A. Calvo 1, 3 and Leona D. Samson 1, 2, 3, 4 1 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 2 Departmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c9159a533b3651cd5c80bbb76ee2b9
http://europepmc.org/articles/PMC5620290
http://europepmc.org/articles/PMC5620290
Autor:
Joshua J. Corrigan, Mariacarmela Allocca, Aprotim Mazumder, Kimberly R. Fake, Leona D. Samson
Publikováno v:
Science signaling. 12(568)
DNA-alkylating agents are commonly used to kill cancer cells, but the base excision repair (BER) pathway they trigger can produce toxic intermediates that damage healthy tissues as well, including retinal degeneration (RD). Apoptosis, a process of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338434e98d16b2d5608b777177291f95
https://pubmed.ncbi.nlm.nih.gov/30755477
https://pubmed.ncbi.nlm.nih.gov/30755477
Autor:
Sureshkumar Muthupalani, Joshua J. Corrigan, Kimberly R. Fake, Mariacarmela Allocca, Leona D. Samson, Roderick T. Bronson, Jennifer A. Calvo
Publikováno v:
Impact Journals
Oncotarget
Oncotarget
ephrotoxicity is a common toxic side-effect of chemotherapeutic alkylating agents. Although the base excision repair (BER) pathway is essential in repairing DNA alkylation damage, under certain conditions the initiation of BER produces toxic repair i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095c948cf58bf0253d2fe19dd04f6686
https://doi.org/10.18632/oncotarget.10440
https://doi.org/10.18632/oncotarget.10440
Autor:
Roderick T. Bronson, Carrie M Margulies, Dragony Fu, Mariacarmela Allocca, Arne Klungland, Leona D. Samson, Sophea Chhim, Jennifer J. Jordan
Publikováno v:
Cell Death & Disease
Regulated necrosis has emerged as a major cell death mechanism in response to different forms of physiological and pharmacological stress. The AlkB homolog 7 (ALKBH7) protein is required for regulated cellular necrosis in response to chemotherapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa71f196ed2d25d9df055af8a31664c7
http://europepmc.org/articles/PMC5550884
http://europepmc.org/articles/PMC5550884
Autor:
Nona Abolhassani, Mohammad R. Ebrahimkhani, Aprotim Mazumder, Sureshkumar Muthupalani, Mariacarmela Allocca, Leona D. Samson, Jennifer A. Calvo, Ali Daneshmand, Iny Jhun, Cenk Ayata
Inflammation is accompanied by the release of highly reactive oxygen and nitrogen species (RONS) that damage DNA, among other cellular molecules. Base excision repair (BER) is initiated by DNA glycosylases and is crucial in repairing RONS-induced DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b2b2c3a59c5322813ac9e01c3845a6
https://europepmc.org/articles/PMC4234618/
https://europepmc.org/articles/PMC4234618/
Publikováno v:
Pathobiology of Human Disease ISBN: 9780123864574
The outer retina is composed primarily of rod and cone photoreceptor (PR) cells and retina pigment epithelial cells. These cells serve as the main cells of the retina and initiate the process of phototransduction whereby light is converted and transm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::886f09eebe6cc5bf797a0b4286b1d3d2
https://doi.org/10.1016/b978-0-12-386456-7.04706-7
https://doi.org/10.1016/b978-0-12-386456-7.04706-7