The transcriptomic landscape of elderly acute myeloid leukemia identifies B7H3 and BANP as a favorable signature in high-risk patients

Autor: Sara Villar, Beñat Ariceta, Xabier Agirre, Aura Daniela Urribarri, Rosa Ayala, David Martínez-Cuadrón, Juan Miguel Bergua, Susana Vives, Lorenzo Algarra, Mar Tormo, Pilar Martínez, Josefina Serrano, Catia Simoes, Pilar Herrera, Maria José Calasanz, Ana Alfonso-Piérola, Bruno Paiva, Joaquín Martínez-López, Jesús F. San Miguel, Felipe Prósper, Pau Montesinos

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Acute myeloid leukemia (AML) in the elderly remains a clinical challenge, with a five-year overall survival rate below 10%. The current ELN 2017 genetic risk classification considers cytogenetic and mutational characteristics to stratify fit AML pati

Externí odkaz: https://doaj.org/article/3518c66232c441da81dbca6328896425

Integrated flow cytometry and sequencing to reconstruct evolutionary patterns from dysplasia to acute myeloid leukemia

Autor: Catia Simoes, Maria-Carmen Chillon, David Martínez-Cuadrón, Maria-José Calasanz, María-Belén Vridiales, Iria Vazquez, Montserrat Hernández-Ruano, Beñat Ariceta, Paula Aguirre-Ruiz, Leire Burgos, Diego Alignani, Sarai Sarvide, Sara Villar, Ana Alfonso Pierola, Felipe Prosper, Rosa Ayala, Joaquin Martínez-López, Juan Miguel Bergua Burgues, Susana Vives, Jose A. Perez-Simon, Maria Garcia-Fortes, Teresa Bernal del Castillo, Mercedes Colorado, Mayte Olave, Juan I. Rodríguez-Gutiérrez, Jorge Labrador, Marcos González, Jesús F. San-Miguel, Miguel Ángel Sanz, Pau Montesinos, Bruno Paiva

Publikováno v: Blood Advances
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Blood advances, 2023, 7(1), 167-173

Clonal evolution in acute myeloid leukemia (AML) originates long before diagnosis and is a dynamic process that may affect survival. However, it remains uninvestigated during routine diagnostic workup. We hypothesized that the mutational status of bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ebb29de33b779945272eff40de879e
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=17131

Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells.

Autor: Antonio Valeri, Maria Eugenia Alonso-Ferrero, Paula Río, María Roser Pujol, José A Casado, Laura Pérez, Ariana Jacome, Xabier Agirre, Maria José Calasanz, Helmut Hanenberg, Jordi Surrallés, Felipe Prosper, Beatriz Albella, Juan A Bueren

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15525 (2010)

Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by the expression of the BCR/ABL fusion oncogene. Although it is well known that CML cells are genetically unstable, the mechanisms accounting for this g

Externí odkaz: https://doaj.org/article/b4a584191bc246d394dc616a54cccc04

Quantification of cyclin D1 and D2 proteins in multiple myeloma identifies different expression patterns from those revealed by gene expression profiling

Autor: Ignacio J. Cardona-Benavides, Irena Misiewicz-Krzeminska, Elizabeta A. Rojas, Cristina De Ramón, Antonio Sanz-Solas, Isabel Isidro, Dalia Quwaider, Aida M. López-Guerrero, Myriam Cuadrado, María-José Calasanz, Laura Rosiñol, Joaquín Martínez-López, Jesús F. San Miguel, María-Victoria Mateos, Luis A. Corchete, Norma C. Gutiérrez

Publikováno v: Haematologica, Vol 109, Iss 3 (2023)

Upregulation of a cyclin D gene determined by expression microarrays is an almost universal event in multiple myeloma (MM), but this finding has not been properly confirmed at the protein level. For this reason, we carried out a quantitative analysis

Externí odkaz: https://doaj.org/article/d2fb4d2c2d1d4ba0898028202a445ac2

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