Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Maria-Grazia De Simoni"'
Autor:
Domenico Mercurio, Francesca Pischiutta, Serena Seminara, Francesca Tribuzio, Ilaria Lisi, Laura Pasetto, Valentina Bonetto, Maria-Grazia De Simoni, Wilhelm Schwaeble, Sadam Yaseen, Thomas Dudler, Elisa R. Zanier, Stefano Fumagalli
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-11 (2024)
Abstract The lectin pathway (LP) of complement mediates inflammatory processes linked to tissue damage and loss of function following traumatic brain injury (TBI). LP activation triggers a cascade of proteolytic events initiated by LP specific enzyme
Externí odkaz:
https://doaj.org/article/71c3b354a8d74e7bafc4e08a65953866
Autor:
Marco Oggioni, Domenico Mercurio, Denise Minuta, Stefano Fumagalli, Katarzyna Popiolek-Barczyk, Marina Sironi, Agata Ciechanowska, Stefania Ippati, Daiana De Blasio, Carlo Perego, Joanna Mika, Cecilia Garlanda, Maria-Grazia De Simoni
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Long pentraxin PTX3, a pattern recognition molecule involved in innate immune responses, is upregulated by pro-inflammatory stimuli, contributors to secondary damage in traumatic brain injury (TBI). We analyzed PTX3 involvement in mice subje
Externí odkaz:
https://doaj.org/article/ab84c6e775b8498fa19cd39f64b559e4
Autor:
Domenico Mercurio, Stefano Fumagalli, Martin K-H Schafer, Jordi Pedragosa, Lionel Dejeumen Claude Ngassam, Verena Wilhelmi, Sarah Winterberg, Anna M. Planas, Eberhard Weihe, Maria-Grazia De Simoni
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The activation of microglia and the infiltration of macrophages are hallmarks of neuroinflammation after acute brain injuries, including traumatic brain injury (TBI). The two myeloid populations share many features in the post-injury inflammatory res
Externí odkaz:
https://doaj.org/article/670028469d06453f9647bdbad65fe2ec
Autor:
Stefano Fumagalli, Fabio Fiordaliso, Carlo Perego, Alessandro Corbelli, Alessandro Mariani, Massimiliano De Paola, Maria-Grazia De Simoni
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Abstract Background Phagocytosis is a key function of myeloid cells and is highly involved in brain ischemic injury. It has been scarcely studied in vivo, thus preventing a deep knowledge of the processes occurring in the ischemic environment. Struct
Externí odkaz:
https://doaj.org/article/59d5a9ddc11143a2aecc5caf2cdd4b62
Autor:
Eliana Sammali, Claudia Alia, Gloria Vegliante, Valentina Colombo, Nadia Giordano, Francesca Pischiutta, Giorgio B. Boncoraglio, Mario Barilani, Lorenza Lazzari, Matteo Caleo, Maria-Grazia De Simoni, Giuseppe Gaipa, Giuseppe Citerio, Elisa R. Zanier
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Transplantation of human bone marrow mesenchymal stromal cells (hBM-MSC) promotes functional recovery after stroke in animal models, but the mechanisms underlying these effects remain incompletely understood. We tested the efficacy of Good M
Externí odkaz:
https://doaj.org/article/4a8c9b8a3d0b47f0851e220fca0f3975
Macrophages are essential for maintaining a M2 protective response early after ischemic brain injury
Autor:
Carlo Perego, Stefano Fumagalli, Elisa R. Zanier, Erika Carlino, Nicolò Panini, Eugenio Erba, Maria-Grazia De Simoni, PhD
Publikováno v:
Neurobiology of Disease, Vol 96, Iss , Pp 284-293 (2016)
Resident microglia and recruited macrophages are major contributors to the post-ischemic inflammatory response. Initially considered functionally homogeneous populations, data now suggest distinct but still controversial roles after brain injury. Usi
Externí odkaz:
https://doaj.org/article/30804098624246a29dfd79dc9e3ce4a7
Autor:
Ersilia Varone, Diego Pozzer, Simona Di Modica, Alexander Chernorudskiy, Leonardo Nogara, Martina Baraldo, Mario Cinquanta, Stefano Fumagalli, Rocio Nur Villar-Quiles, Maria-Grazia De Simoni, Bert Blaauw, Ana Ferreiro, Ester Zito
Publikováno v:
Redox Biology, Vol 24, Iss , Pp - (2019)
Selenoprotein N (SELENON) is an endoplasmic reticulum (ER) protein whose loss of function leads to a congenital myopathy associated with insulin resistance (SEPN1-related myopathy). The exact cause of the insulin resistance in patients with SELENON l
Externí odkaz:
https://doaj.org/article/73fb0f5074fc465186227627ec912a26
Autor:
Agata Ciechanowska, Katarzyna Ciapała, Katarzyna Pawlik, Marco Oggioni, Domenico Mercurio, Maria-Grazia De Simoni, Joanna Mika
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 45 (2020)
The complement system is involved in promoting secondary injury after traumatic brain injury (TBI), but the roles of the classical and lectin pathways leading to complement activation need to be clarified. To this end, we aimed to determine the abili
Externí odkaz:
https://doaj.org/article/bbf7a4ea514d4eee89de1f7cb13b4a38
Autor:
Katrine Pilely, Stefano Fumagalli, Anne Rosbjerg, Ninette Genster, Mikkel-Ole Skjoedt, Carlo Perego, Angela M. R. Ferrante, Maria-Grazia De Simoni, Peter Garred
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Inflammation is a part of the initial process leading to atherosclerosis and cholesterol crystals (CC), found in atherosclerotic plaques, which are known to induce complement activation. The pentraxins C-reactive protein (CRP), long pentraxin 3 (PTX3
Externí odkaz:
https://doaj.org/article/e130ea48d2854fb8a8b757082b51a527
Autor:
Claudio Storini, Emanuela Rossi, Veronica Marrella, Maria Distaso, Robert Veerhuis, Carlo Vergani, Luigi Bergamaschini, Maria-Grazia De Simoni
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 1, Pp 10-17 (2005)
Previous studies demonstrated that C1-inhibitor (C1-INH), a complement and contact-kinin systems inhibitor, is neuroprotective in cerebral ischemia. To investigate the mechanism of this action, we evaluated the expression of neurodegeneration and inf
Externí odkaz:
https://doaj.org/article/e261cd70a7e049688c54dfd86079975b