Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection

Autor: Alexandra W. C. Einerhand, Anna Velcich, Jan Dekker, Hans A. Büller, Jules P.P. Meijerink, Adrianus C. J. M. de Bruijn, Ingrid B. Renes, Maria van der Sluis, Johannes B. van Goudoever, Isabelle Van Seuningen, Barbara A. E. de Koning

Publikováno v: Gastroenterology
Gastroenterology, WB Saunders, 2006, 131 (1), pp.117-129. ⟨10.1053/j.gastro.2006.04.020⟩
Gastroenterology, 131, 941-949. W.B. Saunders
Gastroenterology, 2006, 131 (1), pp.117-129. ⟨10.1053/j.gastro.2006.04.020⟩
Gastroenterology, 131(1), 117-129. W.B. Saunders Ltd

Background & Aims: Expression of mucin MUC2, the structural component of the colonic mucus layer, is lowered in inflammatory bowel disease. Our aim was to obtain insight in the role of Muc2 in epithelial protection. Methods: Muc2 knockout (Muc2−/�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2034593fdf619fad43f2bc3111b249
https://doi.org/10.1053/j.gastro.2006.04.020

Mucin muc2 deficiency and weaning influences the expression of the innate defense genes reg3ß, reg3¿ and angiogenin-4

Autor: Jerry M. Wells, Maria van der Sluis, Isabelle Van Seuningen, Anita M. Korteland-van Male, Nanda Burger-van Paassen, Peng Lu, Ingrid B. Renes, Adrianus C. J. M. de Bruijn, Jan Dekker, Janneke Witte-Bouma, Linda M. P. Loonen, Johannes B. van Goudoever

Publikováno v: PLoS ONE, 7(6)
PLoS ONE, Vol 7, Iss 6, p e38798 (2012)
PLoS ONE, 7(6):e38798. Public Library of Science
PLoS ONE
Burger-van Paassen, N, Loonen, L M P, Witte-Bouma, J, Korteland-van Male, A M, de Bruijn, A C J M, van der Sluis, M, Lu, P, van Goudoever, J B, Wells, J M, Dekker, J, van Seuningen, I & Renes, I B 2012, ' Mucin Muc2 Deficiency and Weaning Influences the Expression of the Innate Defense Genes Reg3 beta, Reg3 gamma and Angiogenin-4 ', PLoS ONE, vol. 7, no. 6, e38798 . https://doi.org/10.1371/journal.pone.0038798
PLoS ONE, Public Library of Science, 2012, 7 (6), pp.e38798. ⟨10.1371/journal.pone.0038798⟩
PLoS ONE 7 (2012) 6
PLoS ONE, 2012, 7 (6), pp.e38798. ⟨10.1371/journal.pone.0038798⟩
PLoS ONE, 7(6). Public Library of Science

International audience; Background: Mucin Muc2 is the structural component of the intestinal mucus layer. Absence of Muc2 leads to loss of this layer allowing direct bacterial-epithelial interactions. We hypothesized that absence of the mucus layer l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d395bcdc844dee59d8c78b6de01cca0
https://research.wur.nl/en/publications/mucin-muc2-deficiency-and-weaning-influences-the-expression-of-th

EuropeaN Energy balance Research to prevent excessive weight Gain among Youth (ENERGY) project: Design and methodology of the ENERGY cross-sectional survey

Autor: Lea Maes, Luis A. Moreno, Dénes Molnár, Yannis Manios, Ilse De Bourdeaudhuij, Jørgen Arendt Jensen, Mai J M Chinapaw, Marloes K. Martens, Maartje M. van Stralen, Nataša Jan, Evangelia Grammatikaki, Maria van der Sluis, Johannes Brug, Elling Bere, Helen J Moore, Amika S. Singh, Saskia J. te Velde

Publikováno v: BMC Public Health, Vol 11, Iss 1, p 65 (2011)
BMC Public Health, 11:65. BioMed Central
BMC Public Health
van Stralen, M M, te Velde, S J, Singh, A S, de Bourdeaudhuij, I, Martens, M K, van der Sluis, M, Manios, Y, Grammatikaki, E, Chin A Paw, M J M, Maes, L, Bere, E, Jensen, J D, Moreno, L, Jan, N, Molnar, D, Moore, H & Brug, J 2011, ' European energy balance research to prevent excessive weight Gain among Youth (ENERGY) project: Design and methodology of the ENERGY cross-sectional survey ', BMC Public Health, vol. 11, 65 . https://doi.org/10.1186/1471-2458-11-65
BMC PUBLIC HEALTH
BMC Public Health; Vol 11
Stralen, M M V, Velde, S J T, Singh, A S, Bourdeaudhuij, I D, Martens, M K, Sluis, M V D, Manios, Y, Grammatikaki, E, Chinapaw, M J M, Maes, L, Bere, E, Jensen, J D, Moreno, L, Jan, N, Molnár, D, Moore, H & Brug, J 2011, ' European energy balance research to prevent excessive weight gain among youth (ENERGY) project : design and methodology of the ENERGY cross-sectional survey ', B M C Public Health, vol. 11, no. 65 . https://doi.org/10.1186/1471-2458-11-65
BMC public health, 2011, Vol.11, pp.65 [Peer Reviewed Journal]

Background Obesity treatment is by large ineffective long term, and more emphasis on the prevention of excessive weight gain in childhood and adolescence is warranted. To inform energy balance related behaviour (EBRB) change interventions, insight in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340a176ae60a38f8fa61d724e2ca50ce
http://www.biomedcentral.com/1471-2458/11/65

Colonic gene expression patterns of mucin Muc2 knockout mice reveal various phases in colitis development

Autor: Peng, Lu, Nanda, Burger-van Paassen, Maria, van der Sluis, Janneke, Witte-Bouma, Jean-Pierre, Kerckaert, Johannes B, van Goudoever, Isabelle, Van Seuningen, Ingrid B, Renes

Publikováno v: Inflammatory bowel diseases. 17(10)

Mucin Muc2 knockout (Muc2(-/-)) mice spontaneously develop colitis.To identify genes and biological responses which play a pivotal role during colitis development in Muc2(-/-) mice, gene expression profiles of colonic tissues from 2- and 4-week-old M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd69b1293a6c975ae3f5ecd5e3991b75
https://pubmed.ncbi.nlm.nih.gov/21910166

Innate defense responses in Muc2 deficient mice: an important role for goblet cells

Autor: Isabelle Van Seuningen, Maria van der Sluis, Nanda Burger-van Paassen, Adrianus C. J. M. de Bruijn, Ingrid B. Renes, Janneke Bouma, Johannes B. van Goudoever

Publikováno v: The FASEB Journal. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c799a94f2a8cb14c0d3926abf79e4f04
https://doi.org/10.1096/fasebj.23.1_supplement.121.2