Co-administration of ascorbic acid and α-tocopherol modifies ascorbic acid and attenuates p38, Akt, and TNF-α expression in spinal cord of rats with neuropathic pain

Autor: Andréa Horst, Maria Flavia Marques Ribeiro, Maria do Carmo Quevedo Santos, Luciano Fraga, Carolina Kolberg, Jéssica Araújo de Souza, Wania Aparecida Partata, Adarly Kroth, Taina Scheid, Elza Maria Santos da Silveira, Ana Paula Konzen Riffel, Geórgia Muccillo Dexheimer

Publikováno v: Nutrire. 45

p38 and Akt plays an important role in neuropathic pain. p38 appears to regulate the SVCT-2 expression, a specific transporter for ascorbic acid (an important antioxidant and neuromodulator). Vitamins C and E induce antinociception and appear to affe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6877c1fa2f828f067de10640f77863b
https://doi.org/10.1186/s41110-019-0113-6

Age-related changes and effects of regular low-intensity exercise on gait, balance, and oxidative biomarkers in the spinal cord of Wistar rats

Autor: Maria do Carmo Quevedo Santos, Taina Scheid, Wania Aparecida Partata, Ana Paula Konzen Riffel, Adarly Kroth, Thaisla Cristiane Borella da Silva, Márcia Trapp, Diane Pereira Silveira, Elza Maria Santos da Silveira

Publikováno v: Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Brazilian Journal of Medical and Biological Research, Vol 52, Iss 7
Brazilian Journal of Medical and Biological Research, Volume: 52, Issue: 7, Article number: e8429, Published: 15 JUL 2019
Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research v.52 n.7 2019
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC

The present study aimed to analyze age-related changes to motor coordination, balance, spinal cord oxidative biomarkers in 3-, 6-, 18-, 24-, and 30-month-old rats. The effects of low-intensity exercise on these parameters were also analyzed in 6-, 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5f84355311cde38a9dd0290313f201

Systemic administration of vitamins C and E attenuates nociception induced by chronic constriction injury of the sciatic nerve in rats

Autor: Maria do Carmo Quevedo Santos, Carolina Kolberg, Jéssica Araújo de Souza, Andréa Horst, Wania Aparecida Partata, Adriane Belló-Klein, Taina Scheid, Ana Paula Konzen Riffel

Publikováno v: Brain Research Bulletin. 121:169-177

Antioxidants have been tested to treat neuropathic pain, and α-Tocopherol (vitamin E--vit. E) and ascorbic acid (vitamin C--vit. C) are potent antioxidants. We assessed the effect of intraperitoneal administration of vit. C (30 mg/kg/day) and vit. E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0e19bb726af4615730f2b74d904236
https://doi.org/10.1016/j.brainresbull.2016.02.004

Treatment with ascorbic acid and α-tocopherol modulates oxidative-stress markers in the spinal cord of rats with neuropathic pain

Autor: Ana Paula Konzen Riffel, Carolina Kolberg, Taina Scheid, J.A. de Souza, Maria do Carmo Quevedo Santos, W.A. Partata, A. Horst, Adriane Belló-Klein

Publikováno v: Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Brazilian Journal of Medical and Biological Research, Vol 51, Iss 4 (2018)
Brazilian Journal of Medical and Biological Research v.51 n.4 2018
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Volume: 51, Issue: 4, Article number: e7097, Published: 01 MAR 2018

Vitamin E (vit. E) and vitamin C (vit. C) are antioxidants that inhibit nociception. The effect of these vitamins on oxidative-stress markers in the spinal cord of rats with chronic constriction injury (CCI) of the sciatic nerve is unknown. This stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498d89ada8b08e27fe95b9828909a5ad

Aging-induced changes in redox biomarkers in rat spinal cord

Autor: Maria do Carmo Quevedo Santos, Thaisla Cristiane Borella da Silva, Wania Aparecida Partata, Elza Maria Santos da Silveira, Ana Paula Kozen Rifell, Adarly Kroth

Publikováno v: Free Radical Biology and Medicine. 120:S67-S68

The lumbosacral spinal cord has been used to explore mechanisms underlying aging-related changes. One aspect of aging that is not fully understood is the effect of redox imbalance between reactive oxygen species (ROS) and antioxidant systems. One ROS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b525cbbe0d147ee13c5922f7098a502e
https://doi.org/10.1016/j.freeradbiomed.2018.04.223