Výsledky vyhledávání - "Maria del Pilar Aoki"

HIF-1α and CD73 expression in cardiac leukocytes correlates with the severity of myocarditis in end-stage Chagas disease patients

Autor: Roberto R. Favaloro, Carlos Vigliano, Liliana Maria Sanmarco, Natalia Eberhardt, Maria del Pilar Aoki, Gastón Bergero

Publikováno v: Journal of leukocyte biologyREFERENCES. 109(1)

Chronic Chagas cardiomyopathy is the main infectious myocarditis worldwide. Almost 30% of Trypanosoma cruzi infected individuals develop slow and progressive myocarditis that leads to ventricular dilation and heart failure. Heart transplantation is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34ace060aec56d4c093ae6b940a71e4
https://pubmed.ncbi.nlm.nih.gov/32450615

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IL-6 promotes M2 macrophage polarization by modulating purinergic signaling and regulates the lethal release of nitric oxide during Trypanosoma cruzi infection

Autor: Maria del Pilar Aoki, Angel Ramón Minguez, Nicolás Eric Ponce, Liliana Maria Sanmarco, Natalia Eberhardt, Martín G. Theumer, Laura Marina Visconti

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863:857-869

The production of nitric oxide (NO) is a key defense mechanism against intracellular pathogens but it must be tightly controlled in order to avoid excessive detrimental oxidative stress. In this study we described a novel mechanism through which inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2414a37cbaa129952391e7457fab6bac
https://doi.org/10.1016/j.bbadis.2017.01.006

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Isolation and Phenotypic Characterization of Inflammatory Cells from Clinical Samples: Purification of Macrophages from Trypanosoma cruzi-Infected Hearts

Autor: Natalia Eberhardt, Liliana Maria Sanmarco, Maria del Pilar Aoki

Publikováno v: Methods in Molecular Biology ISBN: 9781493991471

Trypanosoma cruzi, the causal agent of chronic Chagas cardiomyopathy, exhibits an important tropism for cardiac tissue. In consequence, T. cruzi experimental infection represents a unique model to study cardiac macrophage behavior and effector functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::beb0876d42e5d61813d0754a1aa620bb
https://doi.org/10.1007/978-1-4939-9148-8_28

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Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity model

Autor: María Fernanda Cabral, Liliana Maria Sanmarco, Nicolás Eric Ponce, María Eugenia Cabalén, Susana Gea, Marta Cecilia Andrada, Roxana Carolina Cano, Maria del Pilar Aoki, Luisina I. Onofrio

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Oncotarget

Chronic obesity and Chagas disease (caused by the protozoan Trypanosoma cruzi) represent serious public health concerns. The interrelation between parasite infection, adipose tissue, immune system and metabolism in an obesogenic context, has not been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e814d97703c5d0aba910935bc5342df
https://doi.org/10.18632/oncotarget.7630

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PD-L2 negatively regulates Th1-mediated immunopathology during Fasciola hepatica infection

Autor: Maria del Pilar Aoki, Cinthia C. Stempin, Fabio M. Cerbán, Laura Cervi, Cristian Roberto Falcón, Claudia Cristina Motran

Publikováno v: Oncotarget
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Macrophage plasticity is critical for controlling inflammation including thoseproduced by helminth infections, where alternatively activated macrophages (AAM)are accumulated in tissues. AAM expressing the co-inhibitory molecule programmeddeath ligand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcba97eb504c55e9c837885461c1192
https://www.ncbi.nlm.nih.gov/pubmed/27783986

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Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi

Autor: Déa Maria Serra Villa-Verde, Suse Dayse Silva-Barbosa, Elizangela Silva-Monteiro, Ana Rosa Pérez, Natalia Guiñazú, Oscar Bottasso, Daniella Arêas Mendes-da-Cruz, Maria del Pilar Aoki, Susana Gea, Wilson Savino

Publikováno v: Cytokine & Growth Factor Reviews. 18:107-124

Pathophysiology of Chagas' disease is not completely defined, although innate and adaptative immune responses are crucial. In acute infection some parasite antigens can activate macrophages, and this may result in pro-inflammatory cytokine production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dceec4ee5f556adc6d89a7d516d8ca8
https://doi.org/10.1016/j.cytogfr.2007.01.010

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Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein

Autor: Tamara Tanos, Natalia Guiñazú, Roxana Carolina Cano, Susana Gea, Maria del Pilar Aoki, Omar A. Coso, Andrea Pellegrini

Publikováno v: Microbes and Infection. 8:1723-1731

We have recently reported that Trypanosoma cruzi infection protects cardiomyocytes against apoptosis induced by growth factor deprivation. Cruzipain, a major parasite antigen, reproduced this survival effect by a Bcl-2-dependent mechanism. In this st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53407cf24982cece960b61609d508f00
https://doi.org/10.1016/j.micinf.2006.02.010

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Apoptotic cell death of oestrogen activated lactotrophs induced by tamoxifen

Autor: Maria del Pilar Aoki, Cristina Alicia Maldonado, Agustín Aoki, Elsa Margarita Orgnero

Publikováno v: Tissue and Cell. 35:143-152

Stimulation and inhibition of lactotroph cells cause remarkable morphological and functional changes. In keeping with these changes, the size of the lactotroph cell population undergoes striking alterations due to proliferation or cell death. Factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72276697ef4e29a4f50bffbff55ef9b7
https://doi.org/10.1016/s0040-8166(03)00013-2

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Sexual dimorphism of apoptosis in lactotrophs induced by bromocryptine

Autor: Maria del Pilar Aoki, Cristina Alicia Maldonado, Agustín Aoki

Publikováno v: Histochemistry and Cell Biology. 116:215-222

Interruption of lactation provokes a massive degeneration of surplus lactotrophs in the rat pituitary gland. This process was determined to be non-apoptotic in nature, and this observation raised many questions as cell death by apoptosis has been des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872c243ad817049f5151c5f6dd28a6dc
https://doi.org/10.1007/s004180100307

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Apoptotic and non-apoptotic cell death in hormone-dependent glands

Autor: Agustín Aoki, Cristina Alicia Maldonado, Maria del Pilar Aoki

Publikováno v: Cell and Tissue Research. 291:571-574

The proliferation of cells and cell death are involved in the maintenance of appropriate tissue homeostasis. In the present study, two different mechanisms of cell death were identified in the prostate and pituitary glands when morphological data, fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1110516d57bec79d5f17169399d3ef19
https://doi.org/10.1007/s004410051026

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