Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maria del Mar Garcia-Molina"'
Autor:
Ramón Varón, José Tudela, Carmen Vanessa Ortiz-Ruiz, Maria del Mar Garcia-Molina, Francisco García-Cánovas, Virginia Tomás, Miguel A. Maria-Solano
Publikováno v:
IUBMB Life. 67:757-767
The development of effective tyrosinase inhibitors has become increasingly important in the cosmetic, medicinal, and agricultural industries for application as antibrowning and depigmenting agents. The kinetic mechanisms of action of tyrosinase on mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b046afde705576e0c4144d10a5e919bf
https://doi.org/10.1002/iub.1432
https://doi.org/10.1002/iub.1432
Autor:
Carmen Vanessa Ortiz-Ruiz, Jose Tudela Serrano, Virginia Tomas-Martinez, Francisco García-Cánovas, Maria del Mar Garcia-Molina
Publikováno v:
Journal of Agricultural and Food Chemistry. 63:2162-2171
Many phenolic compounds have been described in the scientific literature as inhibitors of tyrosinase. In this work a test is proposed that allows us to distinguish whether a molecule is an enzyme inhibitor or substrate. The test has several stages. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a557f5019ad2070f4cf98c2c6839d0
https://doi.org/10.1021/jf5051816
https://doi.org/10.1021/jf5051816
Autor:
Francisco García-Cánovas, Maria del Mar Garcia-Molina, José Neptuno Rodríguez-López, Jose Luis Muñoz Muñoz, José Rodriguez Martinez, Pedro Antonio García-Ruiz, Francisco Martínez-Ortiz
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:3360-3369
Hydroquinone (HQ) is used as a depigmenting agent. In this work we demonstrate that tyrosinase hydroxylates HQ to 2-hydroxyhydroquinone (HHQ). Oxy-tyrosinase hydroxylates HQ to HHQ forming the complex met-tyrosinase-HHQ, which can evolve in two diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6573160eb7dcb4e31375fdfb47b68e
https://doi.org/10.1016/j.bmc.2014.04.048
https://doi.org/10.1016/j.bmc.2014.04.048
Autor:
Jose Luis Muñoz-Muñoz, Pedro Antonio García-Ruiz, Manuela Garcia Moreno, José Rodriguez Martinez, Francisco García-Cánovas, Maria del Mar Garcia-Molina, Jose Berna
Publikováno v:
Reaction Kinetics, Mechanisms and Catalysis. 112:305-320
The formation of hydroxyhydroquinone during the action of tyrosinase on hydroquinone is demonstrated for the first time by means of high performance liquid chromatography mass spectrometry. A kinetic mechanism is proposed to explain this action in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a55d56f5ee0b0335912337fb0a04ac14
https://doi.org/10.1007/s11144-014-0723-1
https://doi.org/10.1007/s11144-014-0723-1
Autor:
Francisco García-Sevilla, M. Amo, Manuela García-Moreno, Maria D. Masia, Enrique Arribas, Ricardo Gomez-Ladron de Guevara, Ramón Varón, Milagros Molina-Alarcón, Maria del Mar Garcia-Molina
Publikováno v:
Journal of Mathematical Chemistry. 52:1647-1674
In this paper we extend to enzyme systems the results previously obtained in paper I of this series for linear compartmental systems. We obtain the time course equations for both the enzyme and ligand species involved in the reaction mechanisms, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9558e3d13b97a3921933a797aaf24cfa
https://doi.org/10.1007/s10910-014-0360-y
https://doi.org/10.1007/s10910-014-0360-y
Autor:
M. Amo, Manuela García-Moreno, Enrique Arribas, Ramón Varón, Ricardo Gomez-Ladron de Guevara, Maria del Mar Garcia-Molina, Maria D. Masia, Milagros Molina-Alarcón, Francisco García-Sevilla
Publikováno v:
Journal of Mathematical Chemistry. 52:1675-1689
Software application is implemented in this work to take full advantage of the characteristics of current operating systems and to provide the optimized symbolic kinetic equations for both enzyme and ligand species involved in enzyme reactions. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a156cf94b197a529d15f9be669c807a
https://doi.org/10.1007/s10910-014-0361-x
https://doi.org/10.1007/s10910-014-0361-x
Autor:
José Neptuno Rodríguez-López, Francisco García-Cánovas, Maria del Mar Garcia-Molina, Jose Luis Muñoz-Muñoz, Pedro Antonio García-Ruiz, Jose Berna
Publikováno v:
IUBMB Life. 66:122-127
Hydroxyhydroquinone (HHQ) was characterized kinetically as a tyrosinase substrate. A kinetic mechanism is proposed, in which HHQ is considered as a monophenol or as an o-diphenol, depending on the part of the molecule that interacts with the enzyme.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::473ec5160c63ddfe48939bdefb53c781
https://doi.org/10.1002/iub.1250
https://doi.org/10.1002/iub.1250
Autor:
Pedro Antonio García-Ruiz, Jose Luis Muñoz-Muñoz, Maria del Mar Garcia-Molina, Francisco García-Cánovas, Francisco Garcia-Molina, Francisco García-Sevilla, José Neptuno Rodríguez-López
Publikováno v:
IUBMB Life. 65:793-799
A solvent deuterium isotope effect on the inactivation suicide of tyrosinase in its action on o-diphenols (catechol, 4-methylcatechol, and 4-tert-butylcatechol) was observed. This isotope effect, observed during kinetic studies in the transition phas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c0f1a8ae8c36cf620a597994cb79169
https://doi.org/10.1002/iub.1191
https://doi.org/10.1002/iub.1191
Autor:
José Neptuno Rodríguez-López, Maria del Mar Garcia-Molina, Francisco Garcia-Molina, Jose Berna, Manuela García-Moreno, Pedro Antonio García-Ruiz, Francisco García-Cánovas, Jose Luis Muñoz-Muñoz
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 91:17-24
A study of the diphenolase, o-aminophenol oxidase, and the aromatic o-diamine oxidase activities of tyrosinase carried out by measuring the catalysis and suicide inactivation kinetics provides the following information: catalytic constant, k cat S ,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::512971195f96cad090307e5619b23103
https://doi.org/10.1016/j.molcatb.2013.02.003
https://doi.org/10.1016/j.molcatb.2013.02.003
Autor:
Carmen Vanessa, Ortiz-Ruiz, Miguel Angel, Maria-Solano, Maria Del Mar, Garcia-Molina, Ramon, Varon, Jose, Tudela, Virginia, Tomas, Francisco, Garcia-Canovas
Publikováno v:
IUBMB life. 67(10)
The development of effective tyrosinase inhibitors has become increasingly important in the cosmetic, medicinal, and agricultural industries for application as antibrowning and depigmenting agents. The kinetic mechanisms of action of tyrosinase on mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4db426c9af2ab780aaf89eb41de3b7b
https://pubmed.ncbi.nlm.nih.gov/26399372
https://pubmed.ncbi.nlm.nih.gov/26399372