Identification of Calpain-Activated Protein Functions

Autor: Maria, Del Carmen Lafita-Navarro, Maralice, Conacci-Sorrell

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1915

As opposed to proteasome-mediated proteolysis that leads to protein degradation, calpain proteases carry out limited proteolytic cleavages of their substrates. The cleavage of some substrates can produce active fragments that perform functions that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::63a2fe15754f0a19d521618f930575f5
https://pubmed.ncbi.nlm.nih.gov/30617802

MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis

Autor: Maria del Carmen Lafita-Navarro, Javier León, Miguel Lafarga, Olga Tapia, Eva Garcia-Alegria, Judit Liaño-Pons, Maria T. Berciano, Rosa M. Blanco, Lucía García-Gutiérrez, Jorge Mata-Garrido

Publikováno v: Oncotarget
Oncotarget. 2016 Aug 31
Lafita-Navarro, M D C, Blanco, R, Mata-Garrido, J, Liaño-Pons, J, Tapia, O, García-Gutiérrez, L, García-Alegría, E, Berciano, M T, Lafarga, M & León, J 2016, ' MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis ', Oncotarget, vol. 7, no. 43, pp. 69536-69548 . https://doi.org/10.18632/oncotarget.11766
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Digital.CSIC. Repositorio Institucional del CSIC
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MXD1 is a protein that interacts with MAX, to form a repressive transcription factor. MXD1-MAX binds E-boxes. MXD1-MAX antagonizes the transcriptional activity of the MYC oncoprotein in most models. It has been reported that MYC overexpression leads

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e12896454ac5545fac978ba8c41e44
https://doi.org/10.18632/oncotarget.11766