Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Maria del Carmen Domínguez Horta"'
The biological properties of therapeutic peptides, such as their pharmacokinetics and pharmacodynamics, are correlated with their structure and aggregation properties. Herein, we studied the aggregation properties of a therapeutic peptide (CIGB-814),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::62b6323939b97f1247c0ff08c044a788
https://zenodo.org/record/7804117
https://zenodo.org/record/7804117
Autor:
Hilda Garay-Perez, Alexis Musacchio Lasa, Emanuela Gatto, Gianfranco Bocchinfuso, Francesca Cavalieri, Mariano Venanzi, Maria Del Carmen Domínguez-Horta, Ernesto Placidi, Marco Savioli, Rita Cimino, Matilde López-Abad, Noemi Ferrante Carrante
The biological properties of therapeutic peptides, such as their pharmacokinetics and pharmacodynamics, are correlated with their structure and aggregation properties. Herein, we studied the aggregation properties of a therapeutic peptide (CIGB-814),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39774739d5f3a35e0b4481f93fc1a290
http://hdl.handle.net/2108/284477
http://hdl.handle.net/2108/284477
Autor:
Rafael Venegas-Rodríguez, Anabel Serrano-Díaz, Ruben Peña-Ruiz, Raul Santana-Sánchez, Mabel Hernández-Cedeño, Aliusha Rittoles Navarro, Inti Grecesqui-Cruz, Liam Pérez-Aguilera, Anadys Segura-Fernández, Leticia Rosario-Cruz, Gilliam Martínez-Donato, Gerardo Guillén-Nieto, Maria del Carmen Domínguez- Horta
Publikováno v:
PLOS ONE. 18:e0281111
This paper presents the results of an observational and retrospective study on the therapeutic effects of Jusvinza, an immunomodulatory peptide with anti-inflammatory properties for critically ill COVID-19 patients. This peptide induces regulatory me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f8c506891f0d509266f0250f59db238
https://doi.org/10.1371/journal.pone.0281111
https://doi.org/10.1371/journal.pone.0281111
Autor:
Ruben Manuel Peña Ruiz, Rafael Venegas Rodriguez, Raul Santana Sánchez, Beatriz Mary Santiesteban Licea, Aliusha Rittoles Navarro, Liam Manuel Pérez Aguilera, Alejandro Rittoles Navarro, Alejandro Ávila Galano, Maria del Carmen Dominguez Horta
Publikováno v:
Revista Cubana de Medicina Militar, Vol 53, Iss 3, Pp e024059934-e024059934 (2024)
Introduction: Approximately 10% of human leptospirosis cases progress to severe forms, among which Weil syndrome stands out. This condition can be aggravated by complications associated with antibiotics, such as the Jarisch Herxeimer reaction (JHR) t
Externí odkaz:
https://doaj.org/article/7a7dc465511e4556bf60c0a6e1bd798c
Autor:
Ana Marta López, Luis Javier González, Laura Hernández, Jorge A. Gómez, Maria del Carmen Domínguez Horta, Yusimy Reyes, Dinorah Prada, Oreste Corrales
Publikováno v:
Clinical Rheumatology. 38:955-960
Rheumatoid arthritis (RA) is a chronic T cell-mediated autoimmune disease. Serum autoantibodies against cyclic citrullinated peptides (anti-CCP) are significant markers for diagnosis and prognosis of this disease. Induction of immune tolerance as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237e00bb3397500539f684f707844b26
https://doi.org/10.1007/s10067-018-4360-3
https://doi.org/10.1007/s10067-018-4360-3
Autor:
Alfredo Hernández, Yolanda Cruz, Yusimy Reyes, Ania Cabrales, Norailys Lorenzo, Claudio Molinero, Jorge A. Gómez, Osmel Martinez, Gabriel Padrón, Hilda Garay, Luis Javier González, Vladimir Besada, Leonardo Oramas, Oreste Corrales, Yisel Avila, E. Pérez, Lina Pérez, Maria del Carmen Domínguez Horta, Cabal Carlos, Osvaldo Reyes, Dinorah Prada, Yassel Ramos, Ana Marta López, E González, Yaysel Miñoso, M. López, Yuliet Bermudez
Publikováno v:
Journal of Clinical Trials.
Background: CIGB 814 is an Altered Peptide Ligand (APL) from a CD4+ T-cell epitope of human heat shock protein 60 (HSP60), an auto-antigen involved in the pathogenesis of rheumatoid arthritis (RA). It induced mechanisms associated with restoration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5736d273a88b77d77c56b0b9a0ec296d
https://doi.org/10.4172/2167-0870.1000339
https://doi.org/10.4172/2167-0870.1000339
Autor:
María del Carmen Domínguez Horta, Rafael Venegas Rodríguez, Gerardo Guillén Nieto, Gillian Martínez Donato, Mabel Hernández Cedeño, Mónica Bequet Romero, Rubén Peña Ruiz, Raúl Santana Sánchez, Luis Javier González, Ania Cabrales, Gabriel Padrón, Leticia Rosario Cruz, Idelsis Esquivel Moynelo
Publikováno v:
Anales de la Academia de Ciencias de Cuba, Vol 12, Iss 1 (2022)
Introducción. El CIGB-258 es un péptido, cuyo mecanismo de acción se ha asociado con la inhibición de la inflamación. El presente trabajo tiene como objetivo demostrar que el CIGB-258 reduce la hiperinflamación en los pacientes con COVID-19. M
Externí odkaz:
https://doaj.org/article/dab3b0f9799d4d4ab8b757f757d791af
Autor:
Rafael Venegas Rodríguez, Anabel Serrano Díaz, Rubén Peña Ruiz, Raúl Santana Sánchez, Aliusha Rittoles Navarro, Inti Grecesqui Cruz, Liam Manuel Pérez Aguilera, Anadys Segura Fernández, Mabel Hernández-Cedeño, Leticia Rosario Cruz, Deyli Chacón Montano, Gillian Martínez-Donato, Gerardo Guillén-Nieto, María del Carmen Domínguez Horta
Publikováno v:
Revista Cubana de Medicina Militar, Vol 50, Iss 4, Pp e02101675-e02101675 (2021)
Introduction: Infection with SARS-CoV-2 induces a prothrombotic state in patients, by the combination of hyperinflammatory response and hypoxia. In Cuba, the drug called Jusvinza, based on an immunomodulatory peptide, is used for the treatment of pat
Externí odkaz:
https://doaj.org/article/1bbf749ca5744f84841c0b91c9011f33
Autor:
Rafael Venegas Rodríguez, Rubén Peña Ruiz, Raúl Santana Sánchez, Mónica Bequet-Romero, Mabel Hernández-Cedeño, Beatriz Santiesteban Licea, Ariana García, Pedro Rafel Aroche de Dios, Daniela Oliva Pérez, Leticia Rosario Cruz, Idelsis Esquivel Moynelo, Maura García Sánchez, Gillian Martínez-Donato, Gerardo Guillén-Nieto, María del Carmen Domínguez Horta
Publikováno v:
Revista Cubana de Medicina Militar, Vol 49, Iss 4, Pp e0200926-e0200926 (2020)
Introduction: CIGB-258 is an immunomodulatory peptide with anti-inflammatory properties. Objectives: To establish the therapeutic schedule with CIGB-258 peptide for COVID-19 critically ill patients. In addition, to define the criteria for use and sch
Externí odkaz:
https://doaj.org/article/bbc2ffd1daa040298becb1ca3dbb36f7
Autor:
Maria del Carmen Domínguez-Horta, Anabel Serrano-Díaz, Mabel Hernández-Cedeño, Gillian Martínez-Donato, Gerardo Guillén-Nieto
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cytokines are secretion proteins that mediate and regulate immunity and inflammation. They are crucial in the progress of acute inflammatory diseases and autoimmunity. In fact, the inhibition of proinflammatory cytokines has been widely tested in the
Externí odkaz:
https://doaj.org/article/074243b55e61448c81c8bd1958e8e95e