Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Maria Zena Miranda"'
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 6040 (2021)
A lesser known but crucially important downstream effect of Rho family GTPases is the regulation of gene expression. This major role is mediated via the cytoskeleton, the organization of which dictates the nucleocytoplasmic shuttling of a set of tran
Externí odkaz:
https://doaj.org/article/54f36dce759040bc95ac33fbc63decc8
Autor:
Neal I. Callaghan, Lauren J. Durland, Wenliang Chen, Uros Kuzmanov, Maria Zena Miranda, Zahra Mirzaei, Ronald G. Ireland, Erika Yan Wang, Karl Wagner, Michelle M. Kim, Julie Audet, J. Paul Santerre, Anthony O. Gramolini, Filio Billia, Milica Radisic, Seema Mital, James Ellis, Peter H. Backx, Craig A. Simmons
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) hold tremendous promise for in vitro modeling to assess native myocardial function and disease mechanisms as well as testing drug safety and efficacy. However, current iPSC- CMs are func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dc91b80e24affa194527927e6fab5fe
https://doi.org/10.1101/2022.10.10.507929
https://doi.org/10.1101/2022.10.10.507929
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 6040, p 6040 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 6040, p 6040 (2021)
A lesser known but crucially important downstream effect of Rho family GTPases is the regulation of gene expression. This major role is mediated via the cytoskeleton, the organization of which dictates the nucleocytoplasmic shuttling of a set of tran
Autor:
Tony Yeung, Janne Folke Bialik, Katalin Szászi, Stine F. Pedersen, Maria Zena Miranda, Pam Speight, Qinghong Dan, Andras Kapus
Publikováno v:
Journal of Biological Chemistry. 292:14902-14920
Hippo pathway transcriptional coactivators TAZ and YAP and the TGF-β1 (TGFβ) effector Smad3 regulate a common set of genes, can physically interact, and exhibit multilevel cross-talk regulating cell fate-determining and fibrogenic pathways. However
Autor:
Caterina Di Ciano-Oliveira, Mei Ding, Ori D. Rotstein, Michael Kofler, Pam Speight, Maria Zena Miranda, Janne Folke Bialik, Stine F. Pedersen, Qinghong Dan, Katalin Szászi, Andras Kapus
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Bialik, J F, Ding, M, Speight, P, Dan, Q, Miranda, M Z, Di Ciano-Oliveira, C, Kofler, M M, Rotstein, O D, Pedersen, S F, Szászi, K & Kapus, A 2019, ' Profibrotic epithelial phenotype : a central role for MRTF and TAZ ', Scientific Reports, vol. 9, 4323, pp. 1-14 . https://doi.org/10.1038/s41598-019-40764-7
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Bialik, J F, Ding, M, Speight, P, Dan, Q, Miranda, M Z, Di Ciano-Oliveira, C, Kofler, M M, Rotstein, O D, Pedersen, S F, Szászi, K & Kapus, A 2019, ' Profibrotic epithelial phenotype : a central role for MRTF and TAZ ', Scientific Reports, vol. 9, 4323, pp. 1-14 . https://doi.org/10.1038/s41598-019-40764-7
Epithelial injury is a key initiator of fibrosis but - in contrast to the previous paradigm - the epithelium in situ does not undergo wide-spread epithelial-mesenchymal/myofibroblast transition (EMT/EMyT). Instead, it assumes a Profibrotic Epithelial
Publikováno v:
The FASEB Journal. 34:1-1
Autor:
Károly Fátyol, Matthew Rozycki, Maria Zena Miranda, Jessica Lam, Pam Speight, Monika Lodyga, Andras Kapus
Publikováno v:
Molecular Biology of the Cell
Myofibroblast transition from mesenchymal or epithelial precursors triggers loss of the primary cilium. In epithelial cells this requires contact injury and TGFβ and is mediated by Rac- and Smad3-dependent myosin phosphorylation. Thus the myofibrobl
Publikováno v:
The FASEB Journal. 29