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pro vyhledávání: '"Maria Ysabel Lesaca-Medina"'
Autor:
L. L. Darga, Richard B. Everson, Maria Ysabel Lesaca-Medina, Jeffrey W. Taub, Patricia Alcasabas, Enrique M. Ostrea, Andrew C. Haller, G. Goyette, Yaddanapudi Ravindranath, Luz del Rosario
Publikováno v:
Pediatric Blood & Cancer. 51:178-182
Background 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism. Polymorphisms at the C677T and A1298C loci are associated with reduced activity; consequently more folate substrates are shunted toward thymidylate