CYP27A1 expression is associated with risk of late lethal estrogen receptor-positive breast cancer in postmenopausal patients

Autor: Siker Kimbung, Maria Inasu, Tor Stålhammar, Björn Nodin, Karin Elebro, Helga Tryggvadottir, Maria Ygland Rödström, Karin Jirström, Karolin Isaksson, Helena Jernström, Signe Borgquist

Publikováno v: Breast Cancer Research, Vol 22, Iss 1, Pp 1-13 (2020)

Abstract Background 27-Hydroxycholesterol (27HC) stimulates estrogen receptor-positive (ER+) breast cancer (BC) progression. Inhibiting the sterol 27-hydroxylase (CYP27A1) abrogates these growth-promoting effects of 27HC in mice. However, the signifi

Externí odkaz: https://doaj.org/article/dc9b2df2276b447bbb83d11c19cb5da6

Pre- and Postoperative Circulating IGF-I, IGFBP-3, and IGFBP-7 Levels in Relation to Endocrine Treatment and Breast Cancer Recurrence: A Nested Case-Control Study

Autor: Ann H. Rosendahl, Sofie Björner, Maria Ygland Rödström, Karin Jirström, Signe Borgquist, Christian Ingvar, Michael N. Pollak, Helena Jernström

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Insulin-like growth factor-I (IGF-I) and its binding proteins (BPs) have been associated with breast cancer risk, especially high IGF-I concentrations and the biologically active fraction estimated as the IGF-I/IGFBP-3 molar ratio. The relation of ci

Externí odkaz: https://doaj.org/article/b627a2859b074c8d9992b03620b868da

The Prognostic Impact of Intratumoral Aryl Hydrocarbon Receptor in Primary Breast Cancer Depends on the Type of Endocrine Therapy:A Population-Based Cohort Study

Autor: Helga Tryggvadottir, Emma Sandén, Sofie Björner, Alessandra Bressan, Maria Ygland Rödström, Somayeh Khazaei, Dean P. Edwards, Björn Nodin, Karin Jirström, Karolin Isaksson, Signe Borgquist, Helena Jernström

Publikováno v: Tryggvadottir, H, Sandén, E, Björner, S, Bressan, A, Ygland Rödström, M, Khazaei, S, Edwards, D P, Nodin, B, Jirström, K, Isaksson, K, Borgquist, S & Jernström, H 2021, ' The Prognostic Impact of Intratumoral Aryl Hydrocarbon Receptor in Primary Breast Cancer Depends on the Type of Endocrine Therapy : A Population-Based Cohort Study ', Frontiers in Oncology, vol. 11, 642768 . https://doi.org/10.3389/fonc.2021.642768
Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)

The aryl hydrocarbon receptor (AhR) is a master regulator of multiple pathways involved in breast cancer, and influences the estrogen receptor alpha (ER) and aromatase/CYP19A1. The purpose of this study was to elucidate the interplay between intratum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a592520b3102e7983fe6bdd410469b1b
https://pure.au.dk/portal/da/publications/the-prognostic-impact-of-intratumoral-aryl-hydrocarbon-receptor-in-primary-breast-cancer-depends-on-the-type-of-endocrine-therapy(5c42f2cc-96db-4cef-ac1c-ccff86c75d13).html

The impact of body size changes on recurrence risk depends on age and estrogen receptor status in primary breast cancer

Autor: Helena Jernström, Xuyian Kenéz, Andrea Markkula, Karolin Isaksson, Helga Tryggvadottir, Maria Ygland Rödström, Signe Borgquist

Publikováno v: Tryggvadottir, H, Ygland Rödström, M, Markkula, A, Kenéz, X, Isaksson, K, Borgquist, S & Jernström, H 2019, ' The impact of body size changes on recurrence risk depends on age and estrogen receptor status in primary breast cancer ', Cancer Causes & Control, vol. 30, no. 11, pp. 1157-1170 . https://doi.org/10.1007/s10552-019-01227-6

Purpose To investigate the prognostic impact of body size changes during the first postoperative year in breast cancer. Methods A cohort of 1,317 primary breast cancer patients included in Sweden (2002–2014) underwent body size measurements at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7719625d0bfa3f6a2ce63d852bb12cdd
https://pure.au.dk/portal/da/publications/the-impact-of-body-size-changes-on-recurrence-risk-depends-on-age-and-estrogen-receptor-status-in-primary-breast-cancer(b2766600-e618-4eb0-bfc5-50e0f4dc8aa2).html