Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Maria Victoria Silva Elipe"'
Publikováno v:
International Journal of Analytical Chemistry, Vol 2009 (2009)
In the initial scale-up batches of the experimental drug substance AMG 517, a pair of unexpected impurities was observed by HPLC. Analysis of data from initial LC-MS experiments indicated the presence of two dimer-like molecules. One impurity had an
Externí odkaz:
https://doaj.org/article/16d1035075644c3c93f30a7b89eeaadb
Publikováno v:
Organic Process Research & Development. 26:657-660
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aea01adaf6b190b498cbd555fc0af090
https://doi.org/10.1021/acs.oprd.1c00131
https://doi.org/10.1021/acs.oprd.1c00131
Autor:
Maria Victoria Silva Elipe, Kyle D. Baucom, Derek B. Brown, Kyle Quasdorf, Seb Caille, James I. Murray
Publikováno v:
The Journal of Organic Chemistry. 87:1977-1985
The ipso nitration of aryl boronic acid derivatives has been developed using fuming nitric acid as the nitrating agent. This facile procedure provides efficient and chemoselective access to a variety of aromatic nitro compounds. While several activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9504adeb56930024c90b9a3bb215e45b
https://doi.org/10.1021/acs.joc.1c00886
https://doi.org/10.1021/acs.joc.1c00886
Autor:
Andrew Cosbie, Kyle D. Baucom, Seb Caille, Maria Victoria Silva Elipe, Kyle Quasdorf, James I. Murray
Publikováno v:
Organic Process Research & Development. 24:1523-1530
During development of a radical benzylic bromination, observation of polymerized by-products and variation in isolated yields warranted an in-depth mechanistic investigation to ensure process under...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e780750b6db5113ec6dc2e493925817
https://doi.org/10.1021/acs.oprd.0c00256
https://doi.org/10.1021/acs.oprd.0c00256
Autor:
Donald Pooke, Maria Victoria Silva Elipe, Alan H. Cherney, Neil Donovan, Robert Krull, Jason S. Tedrow, Kimberly L. Colson
Publikováno v:
Organic Process Research & Development. 24:1428-1434
Monitoring chemical reactions by nuclear magnetic resonance (NMR) is an established and valuable approach for process understanding, robustness, scalability, and control in the pharmaceutical industry. Understanding speciation, reaction rates, and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6c3077bba2a83da9e4b2677385c5d59
https://doi.org/10.1021/acs.oprd.0c00125
https://doi.org/10.1021/acs.oprd.0c00125
Autor:
Gilles Gorins, Matthew M. Bio, John T. Colyer, Jason S. Tedrow, Maria Victoria Silva Elipe, Austin G. Smith, Shawn D. Walker, Seb Caille, Jones Sian, Khalid Diker
Publikováno v:
Organic Process Research & Development. 24:1164-1174
We describe herein the development of a scalable Noyori reductive dynamic kinetic resolution to manufacture DLAC, a Δ-lactone precursor to the active pharmaceutical ingredient AMG 232. Central to t...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb2aa2b5d0f396a63de362dda3eaec0e
https://doi.org/10.1021/acs.oprd.9b00427
https://doi.org/10.1021/acs.oprd.9b00427
Autor:
Maria Victoria Silva Elipe
The chapter reviews the recent technology developments and applications of NMR in industry from 2015 to middle 2019. The chapter is divided into sections focused on applications of hyphenated NMR as a continuation of the review article published in 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::912e9329214ef4b83df19caebb8e35a0
https://doi.org/10.1039/9781788010665-00188
https://doi.org/10.1039/9781788010665-00188
Autor:
Austin G. Smith, Shawn D. Walker, Tiffany L. Correll, David Yeung, Michael T. Corbett, Brian M. Cochran, John L. Tucker, Matthew M. Bio, Filisaty Vounatsos, Greg Wells, Siân C. Jones, Tawnya G. Flick, Maria Victoria Silva Elipe, Seb Caille, Yuan-Qing Fang
Publikováno v:
The Journal of organic chemistry. 84(8)
A robust process to manufacture AMG 232 was developed to deliver drug substance of high purity. Highlights of the commercial process development efforts include the following: (i) use of a novel bench-stable Vilsmeier reagent, methoxymethylene- N, N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6c9632861a120de34683254bd79e21
https://pubmed.ncbi.nlm.nih.gov/30557503
https://pubmed.ncbi.nlm.nih.gov/30557503
Autor:
Kirby Wong-Moon, John R. Huckins, Kevin Crossley, Jason S. Tedrow, Jason Simiens, Maria Victoria Silva Elipe, Hong-Xun Guo, Chul Yoo, Fang Xia
Publikováno v:
Magnetic Resonance in Chemistry. 55:253-262
During the formation of a tetrazole ring on an investigational drug, two in-process impurities were detected and analyzed by LC-MS, which suggested that both impurities were drug-related with the same mass-to-charge ratio. To understand and control t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6235b20cc9f3d5d13f1a8667b5e087c
https://doi.org/10.1002/mrc.4413
https://doi.org/10.1002/mrc.4413
Autor:
Maria Victoria Silva Elipe
Publikováno v:
Magnetic Resonance in Chemistry. 57:775-776
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d864d5e8a8367f9b5955ba1b64089ba4
https://doi.org/10.1002/mrc.4929
https://doi.org/10.1002/mrc.4929