Výsledky vyhledávání - "Maria Victória Souto-Silva"

Akademický článek

Toxicity and Dermatokinetic Analysis of Ibrutinib in Human Skin Models

Autor: Maria Victória Souto-Silva, Elizabete C. I. Bispo, Lucas F. F. Albuquerque, Stefhani Barcelos, Emãnuella M. Garcez, Luana S. Quilici, Florêncio Figueiredo Cavalcanti Neto, Eliza Carla Barroso Duarte, Jankerle N. Boeloni, Felipe Saldanha-Araujo, Guilherme M. Gelfuso, Juliana Lott Carvalho

Publikováno v: Pharmaceutics, Vol 16, Iss 11, p 1377 (2024)

Background/Objectives: Ibrutinib (IBR) is a tyrosine kinase inhibitor under investigation in preclinical and clinical settings as an alternative treatment for melanoma. Nevertheless, the limited oral bioavailability of IBR and the need for high doses

Externí odkaz: https://doaj.org/article/a757fb23569542d8a8ffb47b08adc185

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Akademický článek

Ibrutinib Modulates Proliferation, Migration, Mitochondrial Homeostasis, and Apoptosis in Melanoma Cells

Autor: Fernanda Vitelli Lins, Elizabete Cristina Iseke Bispo, Naomí Souza Rodrigues, Maria Victória Souto Silva, Juliana Lott Carvalho, Guilherme Martins Gelfuso, Felipe Saldanha-Araujo

Publikováno v: Biomedicines, Vol 12, Iss 5, p 1012 (2024)

Ibrutinib, a tyrosine kinase inhibitor with a broad spectrum of action, has been successfully explored to treat hematological and solid cancers. Herein, we investigated the anti-cancer effect of Ibrutinib on melanoma cell lines. Cytotoxicity was eval

Externí odkaz: https://doaj.org/article/311532a666b0483a8d0c21ce7d91752a

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