Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Maria V. Sukhanova"'
Autor:
Natalia A. Lebedeva, Rashid O. Anarbaev, Ekaterina A. Maltseva, Maria V. Sukhanova, Nadejda I. Rechkunova, Olga I. Lavrik
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6927 (2024)
Non-membrane compartments or biomolecular condensates play an important role in the regulation of cellular processes including DNA repair. Here, an ability of XRCC1, a scaffold protein involved in DNA base excision repair (BER) and single-strand brea
Externí odkaz:
https://doaj.org/article/b367756275d94f7d868901c96183ce06
Autor:
Emilie Bertrand, Clément Demongin, Ioana Dobra, Juan Carlos Rengifo-Gonzalez, Anastasia S. Singatulina, Maria V. Sukhanova, Olga I. Lavrik, David Pastré, Loic Hamon
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract FUS is an RNA-binding protein involved in familiar forms of ALS and FTLD that also assembles into fibrillar cytoplasmic aggregates in some neurodegenerative diseases without genetic causes. The self-adhesive prion-like domain in FUS generate
Externí odkaz:
https://doaj.org/article/9379e4e83d2b416ebc9af2f57a01912f
Autor:
Anastasia S. Singatulina, Maria V. Sukhanova, Bénédicte Desforges, Vandana Joshi, David Pastré, Olga I. Lavrik
Publikováno v:
Cells, Vol 11, Iss 23, p 3932 (2022)
DNA damage causes PARP1 activation in the nucleus to set up the machinery responsible for the DNA damage response. Here, we report that, in contrast to cytoplasmic PARPs, the synthesis of poly(ADP-ribose) by PARP1 opposes the formation of cytoplasmic
Externí odkaz:
https://doaj.org/article/bd06beb7732d4dc2bed476bae8da8f5d
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13200 (2022)
Fused in sarcoma (FUS) is involved in the regulation of RNA and DNA metabolism. FUS participates in the formation of biomolecular condensates driven by phase transition. FUS is prone to self-aggregation and tends to undergo phase transition both with
Externí odkaz:
https://doaj.org/article/4c6544d5e49e41bd8c00b74951229935
Autor:
Alexey V. Beletsky, Alexander N. Malyavko, Maria V. Sukhanova, Eugenia S. Mardanova, Maria I. Zvereva, Olga A. Petrova, Yulia Yu. Parfenova, Maria P. Rubtsova, Andrey V. Mardanov, Olga I. Lavrik, Olga A. Dontsova, Nikolai V. Ravin
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-12 (2017)
Abstract Background In the course of replication of eukaryotic chromosomes, the telomere length is maintained due to activity of telomerase, the ribonucleoprotein reverse transcriptase. Abolishing telomerase function causes progressive shortening of
Externí odkaz:
https://doaj.org/article/a6498b8cbe8c48f28996aeb08d7b0fcd
Autor:
Anastasia S. Singatulina, Loic Hamon, Maria V. Sukhanova, Bénédicte Desforges, Vandana Joshi, Ahmed Bouhss, Olga I. Lavrik, David Pastré
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1809-1821.e5 (2019)
Summary: PARP-1 synthesizes long poly(ADP-ribose) chains (PAR) at DNA damage sites to recruit DNA repair factors. Among proteins relocated on damaged DNA, the RNA-binding protein FUS is one of the most abundant, raising the issue about its involvemen
Externí odkaz:
https://doaj.org/article/3bbc96ff185d4201bd1f307312bfe809
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7020 (2020)
The fused in sarcoma (FUS) protein combines prion-like properties with a multifunctional DNA/RNA-binding domain and has functions spanning the regulation of RNA metabolism, including transcription, pre-mRNA splicing, mRNA transport and translation. I
Externí odkaz:
https://doaj.org/article/b943c8fa56a945d7b2f8e3563ca77751
Autor:
Yuliya V. Sherstyuk, Nikita V. Ivanisenko, Alexandra L. Zakharenko, Maria V. Sukhanova, Roman Y. Peshkov, Ilia V. Eltsov, Mikhail M. Kutuzov, Tatiana A. Kurgina, Ekaterina A. Belousova, Vladimir A. Ivanisenko, Olga I. Lavrik, Vladimir N. Silnikov, Tatyana V. Abramova
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 1, p 214 (2019)
We report on the design, synthesis and molecular modeling study of conjugates of adenosine diphosphate (ADP) and morpholino nucleosides as potential selective inhibitors of poly(ADP-ribose)polymerases-1, 2 and 3. Sixteen dinucleoside pyrophosphates c
Externí odkaz:
https://doaj.org/article/a99fca0db3664b76a3baf2d744d80c64
Autor:
Sergey G. Akulitzky, Victor M. Amoskov, Darya N. Arslanova, Andrei A. Belov, N. Vasiliev Vyacheslav, Sergey V. Gavrilov, Valery V. Deomidov, Anatoly A. Zaytzev, Marina V. Kaparkova, Roman V. Korotkov, Vladimir P. Kukhtin, Alexey N. Labusov, Evgeny A. Lamzin, Mikhail S. Larionov, Nicolai A. Makhankov, Andrey N. Nezhentzev, Dmitry A. Ovsyannikov, Igor Yu. Rodin, Sergey E. Sytchevsky, Maria V. Sukhanova, Nicolai A. Shatil, Alexander A. Shkulepa, Alexey A. Firsov
Publikováno v:
Modern Transportation Systems and Technologies. 7:14-32
Aim: To test the levitation performance of a hybrid EMS prototype. Materials and Methods: a levitation test setup with a 18 mm thick steel rail was constructed on a basis of the certified test bench 1958U-10-1 for measurement in the range up to 100 k
Publikováno v:
Biochemistry. Biokhimiia. 87(Suppl 1)
Poly(ADP-ribosyl)ation is a post-translational modification of proteins that performs an essential regulatory function in the cellular response to DNA damage. The key enzyme synthesizing poly(ADP-ribose) (PAR) in the cells is poly(ADP-ribose) polymer