Amyloidogenic and anti-amyloidogenic properties of presenilin 1

Autor: Jose Henrique Ledo, Victor Bustos, Maria V. Pulina

Publikováno v: A Tribute to Paul Greengard (1925-2019) ISBN: 9780128225165

Presenilin 1 (PS1) is an intramembrane protease, the active subunit of the γ-secretase complex. Its well-studied function is the amyloidogenic cleavage of the C-terminal fragment of the amyloid precursor protein, also known as C99, to produce the Ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d95e882c88de17244d2124d23ba8aca
https://doi.org/10.1016/bs.apha.2020.09.010

Loss of Cubilin, the intrinsic factor-vitamin B12 receptor, impairs visceral endoderm endocytosis and endodermal patterning in the mouse

Autor: Vincent Lelievre, Olivier Cases, Jérôme Collignon, Anna-Katerina Hadjantonakis, Renata Kozyraki, Aitana Perea-Gomez, Maria V. Pulina

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-46559-0⟩
Scientific Reports, 2019, 9 (1), pp.10168. ⟨10.1038/s41598-019-46559-0⟩
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.10168. ⟨10.1038/s41598-019-46559-0⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)

The visceral endoderm is a polarized epithelial monolayer necessary for early embryonic development in rodents. A key feature of this epithelium is an active endocytosis and degradation of maternal nutrients, in addition to being the source of variou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c754409f3fbcaefddec70d64d4db1d
https://pubmed.ncbi.nlm.nih.gov/31308417

Bidirectional regulation of Aβ levels by Presenilin 1

Autor: Subhash C. Sinha, Marc Flajolet, Paul Greengard, Maria V. Pulina, Victor Bustos, Yildiz Kelahmetoglu, Fred S. Gorelick

Alzheimer's disease (AD) is characterized by accumulation of the β-amyloid peptide (Aβ), which is generated through sequential proteolysis of the amyloid precursor protein (APP), first by the action of β-secretase, generating the β-C-terminal fra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc87fa46e487087189edbfcb0ee4a0a
https://europepmc.org/articles/PMC5502639/

Shape and position of the node and notochord along the bilateral plane of symmetry are regulated by cell–extracellular matrix interactions

Autor: Sophie Astrof, Dong Liang, Maria V. Pulina

Publikováno v: Biology Open
Biology Open, Vol 3, Iss 7, Pp 583-590 (2014)

The node and notochord (and their equivalents in other species) are essential signaling centers, positioned along the plane of bilateral symmetry in developing vertebrate embryos. However, genes and mechanisms regulating morphogenesis of these struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba28d4e860f601da9e15fa42aee852e
http://europepmc.org/articles/PMC4154294

Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis

Autor: Maria V. Pulina, Shuan-Yu Hou, Sophie Astrof, Ashok Mittal

Publikováno v: Developmental Biology. 381(1):73-82

Fibronectin and its major receptor, integrin α5β1 are required for embryogenesis. These mutants have similar phenotypes, although, defects in integrin α5-deficient mice are milder. In this paper, we examined heart development in those mutants, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e8d89437d17283a97de2d251f02ea5