Molecular Phenotyping of AR Signaling for Predicting Targeted Therapy in Castration Resistant Prostate Cancer

Autor: Agus Rizal A. H. Hamid, Maria V. Luna-Velez, Aleksandra M. Dudek, Cornelius F. J. Jansen, Frank Smit, Tilly W. Aalders, Gerald W. Verhaegh, Ewout Schaafsma, John P. M. Sedelaar, Jack A. Schalken

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Castration-resistant prostate cancer (CRPC) is defined by resistance of the tumor to androgen deprivation therapy (ADT). Several molecular changes, particularly in the AR signaling cascade, have been described that may explain ADT resistance. The var

Externí odkaz: https://doaj.org/article/273e898c8dbd4345a42befd9aa73c40e

ONECUT2 restricts Microfold cell numbers in the small intestine; a multi-omics study

Autor: Maria V. Luna Velez, Hannah K. Neikes, Rebecca R. Snabel, Yarah Quint, Chen Qian, Aniek Martens, Gert Jan C. Veenstra, Michael R. Freeman, Simon J. van Heeringen, Michiel Vermeulen

Microfold (M) cells reside in the intestinal epithelium of Peyer’s patches. Their unique ability to take up and transport antigens from the intestinal lumen to the underlying lymphoid tissue is key in the regulation of the gut-associated immune res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d692e65ff73fed81ad605d34ec0398e1
https://doi.org/10.1101/2022.09.01.506202

Delivery of antisense oligonucleotides for splice-correction of androgen receptor pre-mRNA in castration-resistant prostate cancer models using cell-penetrating peptides

Autor: Maria V. Luna Velez, Omar Paulino da Silva Filho, Gerald W. Verhaegh, Onno Hooij, Najoua El Boujnouni, Roland Brock, Jack A. Schalken

Publikováno v: Prostate, 82, 6, pp. 657-665
Prostate, 82, 657-665

Contains fulltext : 248260.pdf (Publisher’s version ) (Open Access) BACKGROUND: Cell-penetrating peptides (CPPs) are a promising approach for delivering antisense oligonucleotides (AONs) as they form nanosized complexes through noncovalent interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a66ba774a04cbe4b6d5fde79367d779
https://repository.ubn.ru.nl/handle/2066/248260

Integrative multi‐omics analysis of intestinal organoid differentiation

Autor: Floriane Baraille, Koen C. Oost, Cristina Furlan, Agnès Ribeiro, Boudewijn M.T. Burgering, Michiel Vermeulen, Pascal W.T.C. Jansen, Lisa van Voorthuijsen, Rik G.H. Lindeboom, Maria J. Rodriguez-Colman, Maria V. Luna-Velez, Hugo J. Snippert

Publikováno v: Molecular Systems Biology
Molecular Systems Biology, EMBO Press, 2018, 14 (6), pp.e8227. ⟨10.15252/msb.20188227⟩
Molecular Systems Biology, 14, 6, pp. 1-16
Molecular Systems Biology, 14, 1-16

International audience; Intestinal organoids accurately recapitulate epithelial homeostasis in vivo, thereby representing a powerful in vitro system to investigate lineage specification and cellular differentiation. Here, we applied a multi-omics fra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4216f22a9983c3ad0d302905002073f3
https://hal.sorbonne-universite.fr/hal-01840432

ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study.

Autor: Luna Velez, Maria V, Neikes, Hannah K, Snabel, Rebecca R, Quint, Yarah, Qian, Chen, Martens, Aniek, Veenstra, Gert Jan C, Freeman, Michael R, van Heeringen, Simon J, Vermeulen, Michiel

Publikováno v: Nucleic Acids Research; 2/22/2023, Vol. 51 Issue 3, p1277-1296, 20p