Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Maria V. Liberti"'
Autor:
Marian Iwamoto, Kelly E. Duncan, Prachi K. Wickremasingha, Tian Zhao, Maria V. Liberti, Lieselotte Lemoine, Tatjana Decaesteker, Sylvie Rottey, Brian M. Maas, Gillian Gillespie, S. Aubrey Stoch
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 10, Pp 1947-1956 (2023)
Abstract Molnupiravir is an orally administered, small‐molecule ribonucleoside prodrug of β‐D‐N4‐hydroxycytidine (NHC) that has demonstrated potent, broad‐spectrum preclinical activity against RNA viruses and has a high barrier to the deve
Externí odkaz:
https://doaj.org/article/f55f7be76e6247dbb0db33febe23a640
Autor:
Hyeyoung Nam, Anirban Kundu, Suman Karki, Garrett J. Brinkley, Darshan S. Chandrashekar, Richard L. Kirkman, Juan Liu, Maria V. Liberti, Jason W. Locasale, Tanecia Mitchell, Sooryanarayana Varambally, Sunil Sudarshan
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
Mounting evidence points to alterations in mitochondrial metabolism in renal cell carcinoma (RCC). However, the mechanisms that regulate the TCA cycle in RCC remain uncharacterized. Here, we demonstrate that loss of TCA cycle enzyme expression is ret
Externí odkaz:
https://doaj.org/article/eb7183e5d0134cfe9561270e096c17b2
Autor:
Michael A. Reid, Annamarie E. Allen, Shiyu Liu, Maria V. Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, Xia Gao, Qian Wang, Ying Liu, Luhua Lai, Jason W. Locasale
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Serine synthesis from glucose is required even when serine is available from the environment. Here, the authors explain this paradox by showing that the enzyme PHGDH enables nucleotide synthesis by coordinating anabolic fluxes related to central carb
Externí odkaz:
https://doaj.org/article/570cbf552bdf471ba93d9ee853a1c9f2
Autor:
Katherine R. Singleton, Lorin Crawford, Elizabeth Tsui, Haley E. Manchester, Ophelia Maertens, Xiaojing Liu, Maria V. Liberti, Anniefer N. Magpusao, Elizabeth M. Stein, Jennifer P. Tingley, Dennie T. Frederick, Genevieve M. Boland, Keith T. Flaherty, Shannon J. McCall, Clemens Krepler, Katrin Sproesser, Meenhard Herlyn, Drew J. Adams, Jason W. Locasale, Karen Cichowski, Sayan Mukherjee, Kris C. Wood
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2796-2812 (2017)
Summary: Diverse pathways drive resistance to BRAF/MEK inhibitors in BRAF-mutant melanoma, suggesting that durable control of resistance will be a challenge. By combining statistical modeling of genomic data from matched pre-treatment and post-relaps
Externí odkaz:
https://doaj.org/article/a96487256cc746dbad7030889edaebee
Autor:
Maria C. Passarelli, Alexandra M. Pinzaru, Hosseinali Asgharian, Maria V. Liberti, Søren Heissel, Henrik Molina, Hani Goodarzi, Sohail F. Tavazoie
Publikováno v:
Nature cell biology, vol 24, iss 3
Tumourigenesis and cancer progression require enhanced global protein translation1-3. Such enhanced translation is caused by oncogenic and tumour-suppressive events that drive the synthesis and activity of translational machinery4,5. Here we report t
Autor:
Maria V. Liberti, Jason W. Locasale
Publikováno v:
Trends in Biochemical Sciences. 45:179-182
Lactate is an end product of glucose metabolism, which serves metabolic and nonmetabolic functions. A new study by Zhang et al. establishes a novel function for lactate whereby it is utilized in a new histone modification, histone lysine lactylation,
Autor:
Zufeng Guo, Jun O. Liu, Jason W. Locasale, Maria V. Liberti, Katherine R. Singleton, Kris C. Wood, Ziwei Dai, Vijyendra Ramesh, Annamarie E. Allen
Publikováno v:
J Biol Chem
Aerobic glycolysis or the Warburg effect (WE) is characterized by increased glucose uptake and incomplete oxidation to lactate. Although the WE is ubiquitous, its biological role remains controversial, and whether glucose metabolism is functionally d
Autor:
Zhiqiang Cheng, Ruo jing Li, A. V.Subba Rao, Hanjing Peng, Yuefan Wang, Yingjun Li, Zufeng Guo, Saraswati Sukumar, Gunter Fischer, Jun O. Liu, Yongmei Xie, Jason W. Locasale, Sam Y. Hong, Jingxin Wang, Wukun Liu, Cordelia Schiene-Fischer, Preethi Korangath, Maria V. Liberti, Heng Zhu, Xue Ying
Publikováno v:
Angew Chem Int Ed Engl
Glucose transporters play an essential role in cancer cell proliferation and survival and have been pursued as promising cancer drug targets. Using microarrays of a library of new macrocycles known as rapafucins, which were inspired by the natural pr
Autor:
Anirban Kundu, Sunil Sudarshan, Richard Kirkman, Sooryanarayana Varambally, Suman Karki, Juan Liu, Darshan S. Chandrashekar, Tanecia Mitchell, Maria V. Liberti, Garrett J. Brinkley, Jason W. Locasale, Hyeyoung Nam
Publikováno v:
JCI Insight
Mounting evidence points to alterations in mitochondrial metabolism in renal cell carcinoma (RCC). However, the mechanisms that regulate the TCA cycle in RCC remain uncharacterized. Here, we demonstrate that loss of TCA cycle enzyme expression is ret
Autor:
Darshan S. Chandrashekar, Hyeyoung Nam, Maria V. Liberti, Tanecia Mitchell, Juan Liu, Sooryanarayana Varambally, Suman Karki, Anirban Kundu, Jason W. Locasale, Garrett J. Brinkley, Richard Kirkman, Sunil Sudarshan
The Warburg effect is one of most-well studied metabolic phenomenon in cancer cells. For the most part, these studies have focused on enhanced rates of glycolysis observed in various models. The presumption has been that mitochondrial metabolism is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f1295bdc946aa41e922159b1e9a945f
https://doi.org/10.1101/2021.02.19.429599
https://doi.org/10.1101/2021.02.19.429599