Výsledky vyhledávání - "Maria V. Golikova"

Akademický článek

Pharmacodynamics of Doripenem Alone and in Combination with Relebactam in an In Vitro Hollow-Fiber Dynamic Model: Emergence of Resistance of Carbapenemase-Producing Klebsiella pneumoniae and the Inoculum Effect

Autor: Elena N. Strukova, Maria V. Golikova, Svetlana A. Dovzhenko, Mikhail B. Kobrin, Stephen H. Zinner

Publikováno v: Antibiotics, Vol 12, Iss 12, p 1705 (2023)

The emergence of bacteria resistant to beta-lactam/beta-lactamase inhibitor combinations is insufficiently studied, wherein the role of the inoculum effect (IE) in decreased efficacy is unclear. To address these issues, 5-day treatments with doripene

Externí odkaz: https://doaj.org/article/0eb162d7b0624be4a67414649c819b3a

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Akademický článek

Fluorescence Microscopy: Determination of Meropenem Activity against Klebsiella pneumoniae

Autor: Kamilla N. Alieva, Maria V. Golikova, Anastasia A. Kuznetsova, Stephen H. Zinner

Publikováno v: Antibiotics, Vol 12, Iss 7, p 1170 (2023)

The development and implementation of diagnostic methods that allow rapid assessment of antibiotic activity against pathogenic microorganisms is an important step towards antibiotic therapy optimization and increase in the likelihood of successful tr

Externí odkaz: https://doaj.org/article/ebef3d9d405245f097b8cbb9bcee680b

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Akademický článek

Meropenem MICs at Standard and High Inocula and Mutant Prevention Concentration Inter-Relations: Comparative Study with Non-Carbapenemase-Producing and OXA-48-, KPC- and NDM-Producing Klebsiella pneumoniae

Autor: Maria V. Golikova, Elena N. Strukova, Kamilla N. Alieva, Vladimir A. Ageevets, Alisa A. Avdeeva, Ofeliia S. Sulian, Stephen H. Zinner

Publikováno v: Antibiotics, Vol 12, Iss 5, p 872 (2023)

The minimal inhibitory concentration (MIC) is conventionally used to define in vitro levels of susceptibility or resistance of a specific bacterial strain to an antibiotic and to predict its clinical efficacy. Along with MIC, other measures of bacter

Externí odkaz: https://doaj.org/article/6c2c243f319840d28b8f2aa1192c39ae

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Akademický článek

Klebsiella pneumoniae Susceptibility to Carbapenem/Relebactam Combinations: Influence of Inoculum Density and Carbapenem-to-Inhibitor Concentration Ratio

Autor: Maria V. Golikova, Kamilla N. Alieva, Alla V. Filimonova, Vladimir A. Ageevets, Ofeliia S. Sulian, Alisa A. Avdeeva, Sergey V. Sidorenko, Stephen H. Zinner

Publikováno v: Biomedicines, Vol 10, Iss 6, p 1454 (2022)

The inoculum effect (IE) is a well-known phenomenon with beta-lactams. At the same time, the IE has not been extensively studied with carbapenem/carbapenemase inhibitor combinations. The antibiotic-to-inhibitor concentration ratio used in susceptibil

Externí odkaz: https://doaj.org/article/271438a92543436db0ec941127731379

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Akademický článek

Predicting the Effects of Carbapenem/Carbapenemase Inhibitor Combinations against KPC-Producing Klebsiella pneumoniae in Time-Kill Experiments: Alternative versus Traditional Approaches to MIC Determination

Autor: Alla V. Filimonova, Maria V. Golikova, Elena N. Strukova, Yury A. Portnoy, Anastasiya A. Kuznetsova, Stephen H. Zinner

Publikováno v: Antibiotics, Vol 10, Iss 12, p 1520 (2021)

Traditionally, the antibacterial activity of β-lactam antibiotics in the presence of β-lactamase inhibitors is determined at the fixed inhibitor concentration. This traditional approach does not consider the ratio of antibiotic-to-inhibitor concent

Externí odkaz: https://doaj.org/article/0351b8d6e87049bca282a5be0d0ccc02

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Akademický článek

MPC-Based Prediction of Anti-Mutant Effectiveness of Antibiotic Combinations: In Vitro Model Study with Daptomycin and Gentamicin against Staphylococcus aureus

Autor: Maria V. Golikova, Elena N. Strukova, Yury A. Portnoy, Stephen H. Zinner, Alexander A. Firsov

Publikováno v: Antibiotics, Vol 10, Iss 10, p 1148 (2021)

To explore whether combined treatments with daptomycin and gentamicin can prevent the development of Staphylococcus aureus resistance, and whether the possible restriction is associated with changes in antibiotic mutant prevention concentrations (MPC

Externí odkaz: https://doaj.org/article/8cde7af0099b4a75a84e1c1012db1140

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Akademický článek

Verification of a Novel Approach to Predicting Effects of Antibiotic Combinations: In Vitro Dynamic Model Study with Daptomycin and Gentamicin against Staphylococcus aureus

Autor: Maria V. Golikova, Elena N. Strukova, Yury A. Portnoy, Stephen H. Zinner, Alexander A. Firsov

Publikováno v: Antibiotics, Vol 9, Iss 9, p 538 (2020)

To explore whether susceptibility testing with antibiotic combinations at pharmacokinetically derived concentration ratios is predictive of the antimicrobial effect, a Staphylococcus aureus strain was exposed to daptomycin and gentamicin alone or in

Externí odkaz: https://doaj.org/article/ed998ad0ca5e4597b77557991b2f06bf

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