Therapeutic efficacy of antibody-drug conjugates targeting GD2-positive tumors

Autor: Daniel V Kalinovsky, Alexey V Kibardin, Irina V Kholodenko, Elena V Svirshchevskaya, Igor I Doronin, Mariya V Konovalova, Maria V Grechikhina, Fedor N Rozov, Sergey S Larin, Sergey M Deyev, Roman V Kholodenko

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 6 (2022)

Externí odkaz: https://doaj.org/article/07250ee509ce49b3a8f14a77f583361b

Targeted Delivery of HSP70 to Tumor Cells via Supramolecular Complex Based on HER2-Specific DARPin9_29 and the Barnase:Barstar Pair

Autor: Ludmila G. Alekseeva, Olga V. Ovsyanikova, Alexey A. Schulga, Maria V. Grechikhina, Olga A. Shustova, Elena I. Kovalenko, Elena V. Svirshchevskaya, Sergey M. Deyev, Alexander M. Sapozhnikov

Publikováno v: Cells, Vol 13, Iss 4, p 317 (2024)

(1) Background: We have previously shown that the use of an artificial supramolecular two-component system based on chimeric recombinant proteins 4D5scFv-barnase and barstar-heat shock protein 70 KDa (HSP70) allows targeted delivery of HSP70 to the s

Externí odkaz: https://doaj.org/article/2b5af5d8233f457481386f74029cfef6

HLA-DR-expressing NK cells: Effective killers suspected for antigen presentation

Autor: Maria V. Grechikhina, Leonid M. Kanevskiy, Alexander M. Sapozhnikov, Maria A. Streltsova, Elena I. Kovalenko, Sofya A. Erokhina

Publikováno v: Journal of Leukocyte Biology. 109:327-337

HLA-DR-expressing cells comprise an intriguing group of NK cells, which combine phenotypic characteristics of both NK cells and dendritic cells. These cells can be found in humans and mice; they are present in blood and tissues in healthy conditions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ca59353eceb6a0215f5b3facb26ce5
https://doi.org/10.1002/jlb.3ru0420-668rr

Reduced Immunosenescence of Peripheral Blood T Cells in Parkinson's Disease with CMV Infection Background

Autor: Julia D. Vavilova, Anna A. Boyko, Natalya V. Ponomareva, Vitaly F. Fokin, Ekaterina Y. Fedotova, Maria A. Streltsova, Sofya A. Kust, Maria V. Grechikhina, Ekaterina V. Bril, Olga S. Zimnyakova, Elena I. Kovalenko, Alexander M. Sapozhnikov

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 13119, p 13119 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13119

Immunosenescence is a process of remodeling the immune system under the influence of chronic inflammation during aging. Parkinson’s disease (PD) is a common age-associated neurodegenerative disorder and is frequently accompanied by neuroinflammatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4bf4eb77791efac2e5de5c36269290
https://pubmed.ncbi.nlm.nih.gov/34884936

A Novel Approach to Anticancer Therapy: Molecular Modules Based on the Barnase:Barstar Pair for Targeted Delivery of HSP70 to Tumor Cells

Autor: M. S. Kilyachus, Alexander M. Sapozhnikov, Anna V. Klinkova, Oleg A. Stremovskiy, Sergey M. Deyev, Elena I. Kovalenko, O. A. Shustova, Maria V. Grechikhina

Publikováno v: Acta Naturae. 10:85-91

One important distinction between many tumor cell types and normal cells consists in the translocation of a number of intracellular proteins, in particular the 70 kDa heat shock protein (HSP70), to the surface of the plasma membrane. It has been demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4461cd3894121a917ca0f7cdf911d243
https://doi.org/10.32607/20758251-2018-10-3-85-91