Interleukin-10 restores glutamate receptor-mediated Ca2+-signaling in brain circuits under loss of Sip1 transcription factor

Autor: A.A. Babaev, Maria V. Turovskaya, Ekaterina A. Epifanova, Egor A. Turovsky, Victor Tarabykin

Publikováno v: International Journal of Neuroscience. 132:114-125

This study aimed to investigate the connection between the mutation of the Sip1 transcription factor and impaired Ca2+-signaling, which reflects changes in neurotransmission in the cerebral cortex in vitro. We used mixed neuroglial cortical cell cult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c01f31433aaa7ff976b023f668707dc
https://doi.org/10.1080/00207454.2020.1803305

Role of Satb1 and Satb2 Transcription Factors in the Glutamate Receptors Expression and Ca2+ Signaling in the Cortical Neurons In Vitro

Autor: Alexey A. Babaev, Elena G. Varlamova, Victor Tarabykin, E. I. Fedotova, Egor A. Turovsky, Maria V. Turovskaya

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 11; Pages: 5968
International Journal of Molecular Sciences, Vol 22, Iss 5968, p 5968 (2021)

Transcription factors Satb1 and Satb2 are involved in the processes of cortex development and maturation of neurons. Alterations in the expression of their target genes can lead to neurodegenerative processes. Molecular and cellular mechanisms of reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbba174f3d283fa1513a9fbbef5ae4a
http://europepmc.org/articles/PMC8198236

Activation of Cx43 Hemichannels Induces the Generation of Ca2+ Oscillations in White Adipocytes and Stimulates Lipolysis

Autor: Elena G. Varlamova, Maria V. Turovskaya, Egor A. Turovsky

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 8095, p 8095 (2021)

The aim of the study was to investigate the mechanisms of Ca2+ oscillation generation upon activation of connexin-43 and regulation of the lipolysis/lipogenesis balance in white adipocytes through vesicular ATP release. With fluorescence microscopy i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e59d01f2078941de6c6d48001d4fa47
https://doi.org/10.3390/ijms22158095

Deregulation of Ca2+-Signaling Systems in White Adipocytes, Manifested as the Loss of Rhythmic Activity, Underlies the Development of Multiple Hormonal Resistance at Obesity and Type 2 Diabetes

Autor: Egor A. Turovsky, Maria V. Turovskaya, V. V. Dynnik

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 10
International Journal of Molecular Sciences, Vol 22, Iss 5109, p 5109 (2021)

Various types of cells demonstrate ubiquitous rhythmicity registered as simple and complex Ca2+-oscillations, spikes, waves, and triggering phenomena mediated by G-protein and tyrosine kinase coupled receptors. Phospholipase C/IP3-receptors (PLC/IP3R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d9c49736b4307ba4f7039a081dabc2
https://doi.org/10.3390/ijms22105109

Mutation in the Sip1 transcription factor leads to a disturbance of the preconditioning of AMPA receptors by episodes of hypoxia in neurons of the cerebral cortex due to changes in their activity and subunit composition. The protective effects of interleukin-10

Autor: Valery P. Zinchenko, Victor Tarabykin, Egor A. Turovsky, A.A. Babaev, Ekaterina A. Epifanova, Maria V. Turovskaya

Publikováno v: Archives of biochemistry and biophysics. 654

The Sip1 mutation plays the main role in pathogenesis of the Mowat-Wilson syndrome, which is characterized by the pronounced epileptic symptoms. Cortical neurons of homozygous mice with Sip1 mutation are resistant to AMPA receptor activators. Disturb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1910eef17f61d56e746f609b2b576b4
https://pubmed.ncbi.nlm.nih.gov/30056076