Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Maria Tsoli"'
Autor:
Ensieh M. Poursani, Daniele Mercatelli, Prahlad Raninga, Jessica L. Bell, Federica Saletta, Felix V. Kohane, Daniel P. Neumann, Ye Zheng, Jourdin R. C. Rouaen, Toni Rose Jue, Filip T. Michniewicz, Piper Schadel, Erin Kasiou, Maria Tsoli, Giuseppe Cirillo, Shafagh Waters, Tyler Shai-Hee, Riccardo Cazzoli, Merryn Brettle, Iveta Slapetova, Maria Kasherman, Renee Whan, Fernando Souza-Fonseca-Guimaraes, Linda Vahdat, David Ziegler, John G. Lock, Federico M. Giorgi, KumKum Khanna, Orazio Vittorio
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract Background Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to enhance their migration, invasion, and resistance to treatments. Recent studies highlight that elevated levels of copper are implicated in cancer progressi
Externí odkaz:
https://doaj.org/article/b17391f9a29d4891bcdc6914896812f8
Autor:
Jacqueline P. Whitehouse, Hilary Hii, Chelsea Mayoh, Marie Wong, Pamela Ajuyah, Paulette Barahona, Louise Cui, Hetal Dholaria, Christine L. White, Molly K. Buntine, Jacob Byrne, Keteryne Rodrigues da Silva, Meegan Howlett, Emily J. Girard, Maria Tsoli, David S. Ziegler, Jason M. Dyke, Sharon Lee, Paul G. Ekert, Mark J. Cowley, Nicholas G. Gottardo, Raelene Endersby
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionEpendymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent decades, with 10-year survival rates stagnating at just 67% for children aged 0-14
Externí odkaz:
https://doaj.org/article/009c2573d20c46b8a58d763a746781a4
Autor:
Benedicte Grebstad Tune, Heena Sareen, Branka Powter, Smadar Kahana-Edwin, Adam Cooper, Eng-Siew Koh, Cheok S. Lee, Joseph W. Po, Geoff McCowage, Mark Dexter, Lucy Cain, Geraldine O’Neill, Victoria Prior, Jonathan Karpelowsky, Maria Tsoli, Lars O. Baumbusch, David Ziegler, Tara L. Roberts, Paul DeSouza, Therese M. Becker, Yafeng Ma
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 2907 (2023)
Genetic histone variants have been implicated in cancer development and progression. Mutations affecting the histone 3 (H3) family, H3.1 (encoded by HIST1H3B and HIST1H3C) and H3.3 (encoded by H3F3A), are mainly associated with pediatric brain cancer
Externí odkaz:
https://doaj.org/article/444c9199ff6b4d05bfdb45dd6101a100
Autor:
Aaminah Khan, Laura D. Gamble, Dannielle H. Upton, Caitlin Ung, Denise M. T. Yu, Anahid Ehteda, Ruby Pandher, Chelsea Mayoh, Steven Hébert, Nada Jabado, Claudia L. Kleinman, Mark R. Burns, Murray D. Norris, Michelle Haber, Maria Tsoli, David S. Ziegler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Diffuse intrinsic pontine glioma (DIPG) is an almost incurable malignant childhood brain tumor. Here, the authors show that the polyamine synthetic pathway is activated in DIPG and that the dual targeting of polyamine synthesis and uptake results in
Externí odkaz:
https://doaj.org/article/4116e5b63fd745dd8d4fa955d44571c8
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer
Autor:
Loretta M S Lau, Chelsea Mayoh, Jinhan Xie, Paulette Barahona, Karen L MacKenzie, Marie Wong, Alvin Kamili, Maria Tsoli, Tim W Failes, Amit Kumar, Emily V A Mould, Andrew Gifford, Shu‐Oi Chow, Mark Pinese, Jamie I Fletcher, Greg M Arndt, Dong‐Anh Khuong‐Quang, Carol Wadham, Daniel Batey, Georgina Eden, Peter Trebilcock, Swapna Joshi, Stephanie Alfred, Anjana Gopalakrishnan, Aaminah Khan, Dylan Grebert Wade, Patrick A Strong, Elodie Manouvrier, Lisa T Morgan, Miriam Span, Jin Yi Lim, Roxanne Cadiz, Caitlin Ung, David M Thomas, Katherine M Tucker, Meera Warby, Geoffrey B McCowage, Luciano Dalla‐Pozza, Jennifer A Byrne, Federica Saletta, Andrew Fellowes, Stephen B Fox, Murray D Norris, Vanessa Tyrrell, Toby N Trahair, Richard B Lock, Mark J Cowley, Paul G Ekert, Michelle Haber, David S Ziegler, Glenn M Marshall
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 4, Pp n/a-n/a (2022)
Abstract Biomarkers which better match anticancer drugs with cancer driver genes hold the promise of improved clinical responses and cure rates. We developed a precision medicine platform of rapid high‐throughput drug screening (HTS) and patient‐
Externí odkaz:
https://doaj.org/article/f2db646d5831450d847f4d18a36cdea2
Autor:
Anahid Ehteda, Sandy Simon, Laura Franshaw, Federico M. Giorgi, Jie Liu, Swapna Joshi, Jourdin R.C. Rouaen, Chi Nam Ignatius Pang, Ruby Pandher, Chelsea Mayoh, Yujie Tang, Aaminah Khan, Caitlin Ung, Ornella Tolhurst, Anne Kankean, Elisha Hayden, Rebecca Lehmann, Sylvie Shen, Anjana Gopalakrishnan, Peter Trebilcock, Katerina Gurova, Andrei V. Gudkov, Murray D. Norris, Michelle Haber, Orazio Vittorio, Maria Tsoli, David S. Ziegler
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108994- (2021)
Summary: Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 is an anti-cancer compound developed from quinacrine that targets facilitates chromatin transcription (
Externí odkaz:
https://doaj.org/article/f3c43c1ed6e44cbd8f4c250a0e00921a
Autor:
Maria Tsoli, Carol Wadham, Mark Pinese, Tim Failes, Swapna Joshi, Emily Mould, Julia X. Yin, Velimir Gayevskiy, Amit Kumar, Warren Kaplan, Paul G. Ekert, Federica Saletta, Laura Franshaw, Jie Liu, Andrew Gifford, Martin A. Weber, Michael Rodriguez, Richard J. Cohn, Greg Arndt, Vanessa Tyrrell, Michelle Haber, Toby Trahair, Glenn M. Marshall, Kerrie McDonald, Mark J. Cowley, David S. Ziegler
Publikováno v:
Cancer Biology & Therapy, Vol 19, Iss 12, Pp 1078-1087 (2018)
Pediatric high grade gliomas (HGG) are primary brain malignancies that result in significant morbidity and mortality. One of the challenges in their treatment is inter- and intra-tumoral heterogeneity. Precision medicine approaches have the potential
Externí odkaz:
https://doaj.org/article/40d80c282f0c4c19a65cd0dbc3b32bea
Autor:
Elisha Hayden, Holly Holliday, Rebecca Lehmann, Aaminah Khan, Maria Tsoli, Benjamin S. Rayner, David S. Ziegler
Publikováno v:
Cancers, Vol 13, Iss 24, p 6251 (2021)
Diffuse midline gliomas (DMGs) are invariably fatal pediatric brain tumours that are inherently resistant to conventional therapy. In recent years our understanding of the underlying molecular mechanisms of DMG tumorigenicity has resulted in the iden
Externí odkaz:
https://doaj.org/article/ce3c22cbf6af4211badc37d240dc5316
Autor:
Caitlin Ung, Maria Tsoli, Jie Liu, Domenico Cassano, Salvador Pocoví-Martínez, Dannielle H. Upton, Anahid Ehteda, Friederike M. Mansfeld, Timothy W. Failes, Annafranca Farfalla, Christopher Katsinas, Maria Kavallaris, Greg M. Arndt, Orazio Vittorio, Giuseppe Cirillo, Valerio Voliani, David S. Ziegler
Publikováno v:
Cancers, Vol 13, Iss 6, p 1278 (2021)
Diffuse Intrinsic Pontine Gliomas (DIPGs) are highly aggressive paediatric brain tumours. Currently, irradiation is the only standard treatment, but is palliative in nature and most patients die within 12 months of diagnosis. Novel therapeutic approa
Externí odkaz:
https://doaj.org/article/efecfefcd8d647a2b93b7cefbc354660
Autor:
Tammy Hennika, Guo Hu, Nagore G Olaciregui, Kelly L Barton, Anahid Ehteda, Arjanna Chitranjan, Cecilia Chang, Andrew J Gifford, Maria Tsoli, David S Ziegler, Angel M Carcaboso, Oren J Becher
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169485 (2017)
Diffuse intrinsic pontine glioma (DIPG), or high-grade brainstem glioma (BSG), is one of the major causes of brain tumor-related deaths in children. Its prognosis has remained poor despite numerous efforts to improve survival. Panobinostat, a histone
Externí odkaz:
https://doaj.org/article/175c50a8cde444dc861faf95823c9a8b