Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Maria Tsirigotis"'
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2130 (2008)
The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood.Herein we demonstrate that expanded polyglutamine protein cytotoxicity is mediated primarily through activation o
Externí odkaz:
https://doaj.org/article/ad94c4a9d94048d2bce1d708c0b8826b
Autor:
M. Beyers, Maria Tsirigotis, John Woulfe, Jan Brun, Douglas A. Gray, Matthew Y. Tang, M. Zhang
Publikováno v:
Annals of the New York Academy of Sciences. 1019:215-218
The K48R mutant ubiquitin can exert profound in vivo protective effects against a variety of insults, including agents of direct clinical relevance. The manipulation of the ubiquitin/proteasome pathway has enormous potential for clinical benefit, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864c9c5523f5de7080c62b0c9496cd82
https://doi.org/10.1196/annals.1297.035
https://doi.org/10.1196/annals.1297.035
Publikováno v:
Lung Cancer. 42:9-21
It has been reported that human lung cancers frequently overexpress both the ubiquitous cell cycle transcription factor B-myb and the ubiquitin carboxyterminal hydrolase UCHL1, an enzyme whose expression is normally limited to neurons and neuroendocr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634343d8ce9907c765891c37acec5342
https://doi.org/10.1016/s0169-5002(03)00279-4
https://doi.org/10.1016/s0169-5002(03)00279-4
Autor:
Maria Tsirigotis, Mei Zhang, Paul K. Y. Wong, Sherry Thurig, Kenneth R. Reuhl, Douglas A. Gray
Publikováno v:
Journal of Virology. 77:7193-7201
ts 1 is a temperature-sensitive mutant of Moloney murine leukemia virus that induces a rapid spongiform encephalopathy in mice infected as newborns. The pathological features include the formation of ubiquitinated inclusions resembling Lewy bodies. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c610efab30d283ffd86f8c8320ef9b6
https://doi.org/10.1128/jvi.77.13.7193-7201.2003
https://doi.org/10.1128/jvi.77.13.7193-7201.2003
Publikováno v:
BMC Systems Biology, Vol 1, Iss 1, p 17 (2007)
BMC Systems Biology
BMC Systems Biology
Background The ubiquitin-proteasome system is responsible for homeostatic degradation of intact protein substrates as well as the elimination of damaged or misfolded proteins that might otherwise aggregate. During ageing there is a decline in proteas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42624db37e0ea190e936404563817c05
https://doi.org/10.1186/1752-0509-1-17
https://doi.org/10.1186/1752-0509-1-17
Publikováno v:
Neuropathology and applied neurobiology. 32(1)
Spinocerebellar ataxia type 1 (SCA1) is an incurable neurodegenerative disease resulting from loss of Purkinje neurones within the cerebellum. The ubiquitin proteasome pathway (UPP) has been implicated in SCA1 but the role of proteolysis in the disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927db3411ed6cf232dc55fa9c69b1e0e
https://pubmed.ncbi.nlm.nih.gov/16409551
https://pubmed.ncbi.nlm.nih.gov/16409551
Publikováno v:
Scopus-Elsevier
Ubiquitinated proteinaceous inclusions are the hallmark of many neurodegenerative diseases. Inefficient proteolysis might lead to the accumulation and ultimate deposition of potentially toxic entities as inclusions within neurons or glial cells. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd34cbc0dd12163475c36c4930093d6
https://pubmed.ncbi.nlm.nih.gov/12944592
https://pubmed.ncbi.nlm.nih.gov/12944592
Publikováno v:
The Journal of biological chemistry. 276(49)
There is convincing evidence from studies in yeast that a functional ubiquitin/proteasome pathway is required to degrade misfolded or oxidatively damaged proteins but for technical reasons, it has been difficult to perform comparable studies in mamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043c958ab9a510034a46e75cb5d5c189
https://pubmed.ncbi.nlm.nih.gov/11598140
https://pubmed.ncbi.nlm.nih.gov/11598140
Publikováno v:
Scopus-Elsevier
The primary pathway for the proteolytic destruction of cellular proteins is through ubiquitin-mediated targeting to the proteasome. This pathway is pivotal not only in the elimination of damaged or misfolded proteins but also in the temporal, develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d5e6eccc3c39eea6b2d6551f6548b0
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034959450&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034959450&partnerID=MN8TOARS
