A unifying mechanism for cancer cell death through ion channel activation by HAMLET.

Autor: Petter Storm, Thomas Kjaer Klausen, Maria Trulsson, James Ho C S, Marion Dosnon, Tomas Westergren, Yinxia Chao, Anna Rydström, Henry Yang, Stine Falsig Pedersen, Catharina Svanborg

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58578 (2013)

Ion channels and ion fluxes control many aspects of tissue homeostasis. During oncogenic transformation, critical ion channel functions may be perturbed but conserved tumor specific ion fluxes remain to be defined. Here we used the tumoricidal protei

Externí odkaz: https://doaj.org/article/69fb7928210a4b369b293ff6c9371286

Changes in proteasome structure and function caused by HAMLET in tumor cells.

Autor: Lotta Gustafsson, Sonja Aits, Patrik Onnerfjord, Maria Trulsson, Petter Storm, Catharina Svanborg

Publikováno v: PLoS ONE, Vol 4, Iss 4, p e5229 (2009)

Proteasomes control the level of endogenous unfolded proteins by degrading them in the proteolytic core. Insufficient degradation due to altered protein structure or proteasome inhibition may trigger cell death. This study examined the proteasome res

Externí odkaz: https://doaj.org/article/b30703d030d24abe9068ad95d991ec2b

A unifying mechanism for cancer cell death through ion channel activation by HAMLET

Autor: Thomas Kjær Klausen, Marion Dosnon, Henry Yang, Yin Xia Chao, Petter Storm, James Ho Cs, Maria Trulsson, Stine F. Pedersen, Anna Rydström, Tomas Westergren, Catharina Svanborg

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58578 (2013)
PLoS ONE; 8(3), no e58578 (2013)
Storm, P, Klausen, T K, Trulsson, M, Ho CS, J, Dosnon, M, Westergren, T, Chao, Y, Rydström, A, Yang, H, Pedersen, S H F & Svanborg, C 2013, ' A unifying mechanism for Cancer cell death through ion channel activation by HAMLET ', P L o S One, vol. 8, no. 3, e58578 . https://doi.org/10.1371/journal.pone.0058578
PLoS ONE

Ion channels and ion fluxes control many aspects of tissue homeostasis. During oncogenic transformation, critical ion channel functions may be perturbed but conserved tumor specific ion fluxes remain to be defined. Here we used the tumoricidal protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb47ee2e68e95e2001b6dcce4330d2fe
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23505537/?tool=EBI

HAMLET Binding to α-Actinin Facilitates Tumor Cell Detachment

Autor: Sonja Aits, Lennart Gisselsson, Maria Trulsson, Catharina Svanborg, Ann-Kristin Mossberg, Yin Xia Chao, Hao Yu, Alexander Urbano

Publikováno v: PLoS ONE; 6(3), no e17179 (2011)
PLoS ONE
PLoS ONE, Vol 6, Iss 3, p e17179 (2011)

Cell adhesion is tightly regulated by specific molecular interactions and detachment from the extracellular matrix modifies proliferation and survival. HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a protein-lipid complex with tumori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f305b1d382ca44d588a01b3b784cc300
http://lup.lub.lu.se/record/1883909/file/1890285.pdf

Can misfolded proteins be beneficial? The HAMLET case

Autor: Petter Storm, Sonja Aits, Anki Mossberg, Filip Persson, Catharina Svanborg, Maria Trulsson, Jenny Pettersson-Kastberg, Lotta Gustafsson, K. Hun Mok

Publikováno v: Annals of medicine. 41(3)

By changing the three-dimensional structure, a protein can attain new functions, distinct from those of the native protein. Amyloid-forming proteins are one example, in which conformational change may lead to fibril formation and, in many cases, neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0ac755a087e29c15e726b1251a7ebd
https://pubmed.ncbi.nlm.nih.gov/18985467