Výsledky vyhledávání

Pluripotency factors regulate the onset of Hox cluster activation in the early embryo

Autor: José Luis Gómez-Skarmeta, Elena López-Jiménez, Fátima Sánchez-Cabo, Héctor Sánchez-Iranzo, Jesus Victorino, Julio Sainz de Aja, Miguel Manzanares, Isabel Rollan, Antonio Barral, Javier Adan, Elisa Santos, Eduardo Andres-Leon, Maria Tiana, Giovanna Giovinazzo, Carlos Torroja, Rafael D. Acemel, Claudio Badia-Careaga, Raquel Rouco

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Science Advances, 8 (28), 1-13

Pluripotent cells are a transient population of the mammalian embryo dependent on transcription factors, such as OCT4 and NANOG, which maintain pluripotency while suppressing lineage specification. However, these factors are also expressed during ear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d12191f6ce3a66e5888efa38bfa42c8
https://hdl.handle.net/20.500.12105/15648

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Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF

Autor: Maria Jose Andreu, Alba Alvarez-Franco, Marta Portela, Daniel Gimenez-Llorente, Ana Cuadrado, Claudio Badia-Careaga, Maria Tiana, Ana Losada, Miguel Manzanares

Publikováno v: Cell reports. 41(3)

The eukaryotic genome is organized in 3D at different scales. This structure is driven and maintained by different chromatin states and by architectural factors, such as the zinc finger protein CTCF. Zygotic genome structure is established de novo af

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38149013bdd52900a1544912ec85e976
https://pubmed.ncbi.nlm.nih.gov/36260992

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Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF

Autor: Portela M, Maria Jose Andreu, Cuadrado A, Miguel Manzanares, Maria Tiana, Claudio Badia-Careaga, Ana Losada, Gimenez-Llorente D, Alba Alvarez-Franco

The eukaryotic genome is tightly packed inside the nucleus, where it is organized in 3D at different scales. This structure is driven and maintained by different chromatin states and by architectural factors that bind DNA, such as the multi-zinc fing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17eaed39db227ed57cde9728079ea9cb
https://doi.org/10.1101/2021.07.07.451492

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Transcriptome and proteome mapping in the sheep atria reveal molecular featurets of atrial fibrillation progression

Autor: Maria Tiana, Ricardo Magni, Raquel Rouco, Miguel Manzanares, Kuljeet Kaur, Sara Cogliati, José Antonio Enríquez, Rafael J. Ramirez, Mohammed Saeed, Fátima Sánchez-Cabo, Guadalupe Guerrero-Serna, José Jalife, Alba Alvarez-Franco

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Digibug. Repositorio Institucional de la Universidad de Granada
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Cardiovascular Research
Digital.CSIC. Repositorio Institucional del CSIC

This work was supported by the Spanish government (BFU2017-84914-P to M.M.; FPI Fellowship to A.A.-F.; FPU Fellowship to R.R.), and in part by grants to J.J. from the National Heart, Lung and Blood Institute (R01 grant HL122352 NIH/NHLBI), the Leducq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4780d301b6837ad9760401f30a914858
http://hdl.handle.net/20.500.12105/14670

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Metabolic labelling of RNA uncovers the contribution of transcription and decay rates on hypoxia-induced changes in RNA levels

Autor: Rosana Hernández, Luis del Peso, Miguel Ángel Fernández-Moreno, Benilde Jiménez, Bárbara Acosta-Iborra, Clara Galiana, Maria Tiana Cerrolaza

Publikováno v: RNA
Digital.CSIC. Repositorio Institucional del CSIC
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© 2020 Tiana et al.
Cells adapt to environmental changes, including fluctuations in oxygen levels, through the induction of specific gene expression programs. However, most transcriptomic studies do not distinguish the relative contribution of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11fb7792cb945fd784159c691e2a735
http://hdl.handle.net/10261/222287

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Erratum to: Transcriptome and proteome mapping in the sheep atria reveal molecular features of atrial fibrillation progression

Autor: Alba Alvarez-Franco, Raquel Rouco, Rafael J Ramirez, Guadalupe Guerrero-Serna, Maria Tiana, Sara Cogliati, Kuljeet Kaur, Mohammed Saeed, Ricardo Magni, Jose Antonio Enriquez, Fatima Sanchez-Cabo, José Jalife, Miguel Manzanares

Publikováno v: Cardiovascular Research

Atrial fibrillation (AF) is a progressive cardiac arrhythmia that increases the risk of hospitalization and adverse cardiovascular events. There is a clear demand for more inclusive and large-scale approaches to understand the molecular drivers respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb877e88f28eded49c403cf95f25005
http://europepmc.org/articles/PMC8479800

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Metabolic labelling of RNA uncovers the contribution of transcription and decay rates on hypoxia-induced changes in RNA levels

Autor: Benilde Jiménez, Maria Tiana Cerrolaza, Miguel Ángel Fernández-Moreno, Clara Galiana-Ribote, Luis del Peso

Cells adapt to environmental changes, including fluctuations in oxygen levels, through the induction of specific gene expression programs. However, most transcriptomic studies do not distinguish the relative contribution of transcription, RNA process

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ea04588e64d503913899375eb11e16
https://doi.org/10.1101/694570

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The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia

Autor: Norma Masson, Francisco García-Río, David R. Mole, Wyeth W. Wasserman, Laura Puente-Santamaria, Bárbara Acosta-Iborra, Pablo Hernansanz-Agustín, Peter J. Ratcliffe, Maria Tiana Cerrolaza, Rebecca Worsley-Hunt, Luis del Peso, Benilde Jiménez

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nucleic Acids Research
Digital.CSIC. Repositorio Institucional del CSIC
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Cells adapt to environmental changes, including fluctuations in oxygen levels, through the induction of specific gene expression programs. To identify genes regulated by hypoxia at the transcriptional level, we pulse-labeled HUVEC cells with 4-thiour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24489861a8998646517a599808f3185e
http://ora.ox.ac.uk/objects/uuid:

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Akademický článek

Regulatory and Functional Connection of Microphthalmia-Associated Transcription Factor and Anti-Metastatic Pigment Epithelium Derived Factor in Melanoma

Autor: Asunción Fernández-Barral, Jose Luis Orgaz, Pablo Baquero, Zaheer Ali, Alberto Moreno, María Tiana, Valentí Gómez, Erica Riveiro-Falkenbach, Carmen Cañadas, Sandra Zazo, Corine Bertolotto, Irwin Davidson, Jose Luis Rodríguez-Peralto, Ignacio Palmero, Federico Rojo, Lasse Dahl Jensen, Luis del Peso, Benilde Jiménez

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 6, Pp 529-542 (2014)

Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor superfamily, has potent anti-metastatic effects in cutaneous melanoma through its direct actions on endothelial and melanoma cells. Here we show that PEDF expression

Externí odkaz: https://doaj.org/article/2fbad16e8fa34639b68b92e2466246f6

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