A Multi-Organ-on-Chip Approach to Investigate How Oral Exposure to Metals Can Cause Systemic Toxicity Leading to Langerhans Cell Activation in Skin

Autor: Jasper J. Koning, Charlotte T. Rodrigues Neves, Katharina Schimek, Maria Thon, Sander W. Spiekstra, Taco Waaijman, Tanja D. de Gruijl, Susan Gibbs

Publikováno v: Frontiers in Toxicology, Vol 3 (2022)

Investigating systemic toxicity in vitro is still a huge challenge. Here, a multi-organ-on-chip approach is presented as a typical case of topical exposure of oral mucosa to metals, which are known to activate the immune system and in turn may result

Externí odkaz: https://doaj.org/article/03ee9840ad47469daf242b6882634272

Comparative phenotypic and functional analysis of migratory dendritic cell subsets from human oral mucosa and skin.

Autor: Ilona Jennifer Kosten, Rieneke van de Ven, Maria Thon, Susan Gibbs, Tanja D de Gruijl

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0180333 (2017)

Antigen exposure to oral mucosa is generally thought to lead to immune tolerance induction. However, very little is known about the subset composition and function of dendritic cells (DC) migrating from human oral mucosa. Here we show that migratory

Externí odkaz: https://doaj.org/article/fc4018798294469fb51efc3ea5dbb96f

Assessment of cytotoxicity and sensitization potential of intradermally injected tattoo inks in reconstructed human skin

Autor: Susan Gibbs, Sebastiaan A. S. van der Bent, Maria Thon, David Fernandez Rivas, Thomas Rustemeyer, Sander W. Spiekstra, Joey J. J. P. Karregat

Publikováno v: Karregat, J J J P, Rustemeyer, T, van der Bent, S A S, Spiekstra, S W, Thon, M, Fernandez Rivas, D & Gibbs, S 2021, ' Assessment of cytotoxicity and sensitization potential of intradermally injected tattoo inks in reconstructed human skin ', Contact Dermatitis, vol. 85, no. 3, pp. 324-339 . https://doi.org/10.1111/cod.13908, https://doi.org/10.1111/cod.13908
Contact Dermatitis, 85(3), 324-339. Wiley-Blackwell
Contact Dermatitis
Karregat, J J J P, Rustemeyer, T, van der Bent, S A S, Spiekstra, S W, Thon, M, Fernandez Rivas, D & Gibbs, S 2021, ' Assessment of cytotoxicity and sensitization potential of intradermally injected tattoo inks in reconstructed human skin ', Contact Dermatitis, vol. 85, no. 3, pp. 324-339 . https://doi.org/10.1111/cod.13908

© 2021 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.Background: The number of people within the European population having at least one tattoo has increased notably, and with it the number of tattoo-associated clinical complica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cec6171c8c03460f1b98c56b66be913
https://research.vumc.nl/en/publications/0ad4a6c4-db83-471c-b75f-e58424c4b851

Comparison of advanced therapy medicinal product gingiva and skin substitutes and their in vitro wound healing potentials

Autor: Melanie Breetveld, Michiel S.P. Haasjes, Rik J. Scheper, Susan Gibbs, C.S. Blok, Maria Thon, Sanne Roffel, Mireille A. Boink, Taco Waaijman

Publikováno v: Journal of Tissue Engineering and Regenerative Medicine
Boink, M A, Roffel, S, Breetveld, M, Thon, M, Haasjes, M S P, Waaijman, T, Scheper, R J, Blok, C S & Gibbs, S 2018, ' Comparison of advanced therapy medicinal product gingiva and skin substitutes and their in vitro wound healing potentials ', Journal of Tissue Engineering and Regenerative Medicine, vol. 12, no. 2, pp. e1088-e1097 . https://doi.org/10.1002/term.2438
Journal of Tissue Engineering and Regenerative Medicine, 12(2), e1088-e1097. John Wiley and Sons Ltd

Skin and oral mucosa substitutes are a therapeutic option for closing hard-to-heal skin and oral wounds. Our aim was to develop bi-layered skin and gingiva substitutes, from 3 mm diameter biopsies, cultured under identical conditions, which are compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321635f1b8444772c3894b846338f185
https://pubmed.ncbi.nlm.nih.gov/28388010

Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium: GLP-1R mediated effects in human myocardium

Autor: Markus, Wallner, Ewald, Kolesnik, Klemens, Ablasser, Mounir, Khafaga, Paulina, Wakula, Senka, Ljubojevic, Eva Maria, Thon-Gutschi, Harald, Sourij, Martin, Kapl, Nicholas J, Edmunds, J Brent, Kuzmiski, David A, Griffith, Igor, Knez, Burkert, Pieske, Dirk, von Lewinski

Publikováno v: Journal of molecular and cellular cardiology. 89

Glucagon-like peptide-1 receptor (GLP-1R) agonists are a rapidly growing class of drugs developed for treating type-2 diabetes mellitus. Patients with diabetes carry an up to 5-fold greater mortality risk compared to non-diabetic patients, mainly as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b27e0e19122cd38cf96dc6e1c200b12b
https://pubmed.ncbi.nlm.nih.gov/26432951