Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Maria Terradas-Terradas"'
Autor:
Anne-Louise Latif, Ashley Newcombe, Sha Li, Kathryn Gilroy, Neil A. Robertson, Xue Lei, Helen J. S. Stewart, John Cole, Maria Terradas Terradas, Loveena Rishi, Lynn McGarry, Claire McKeeve, Claire Reid, William Clark, Joana Campos, Kristina Kirschner, Andrew Davis, Jonathan Lopez, Jun-ichi Sakamaki, Jennifer P. Morton, Kevin M. Ryan, Stephen W. G. Tait, Sheela A. Abraham, Tessa Holyoake, Brian Higgins, Xu Huang, Karen Blyth, Mhairi Copland, Timothy J. T. Chevassut, Karen Keeshan, Peter D. Adams
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
MDM2 and BET inhibitors have shown efficacy in AML treatment. Here, the authors show that the two compounds can synergize through both p53 protein stabilization and inhibition of BRD4-mediated repression of p53 target genes.
Externí odkaz:
https://doaj.org/article/4058dbf2924543a399c2f17c8fd2a6ad
Autor:
Neil A. Robertson, Eric Latorre-Crespo, Maria Terradas-Terradas, Jorge Lemos-Portela, Alison C. Purcell, Benjamin J. Livesey, Robert F. Hillary, Lee Murphy, Angie Fawkes, Louise MacGillivray, Mhairi Copland, Riccardo E. Marioni, Joseph A. Marsh, Sarah E. Harris, Simon R. Cox, Ian J. Deary, Linus J. Schumacher, Kristina Kirschner, Tamir Chandra
Publikováno v:
Robertson, N A, Latorre Crespo, E, Terradas Terradas, M, Lemos Portela, J, Purcell, A C, Livesey, B, Hillary, R, Murphy, L, Fawkes, A, MacGillivray, L, Copland, M, Marioni, R E, Marsh, J A, Harris, S A, Cox, S R, Deary, I J, Schumacher, L J, Kirschner, K & Chandra, T 2022, ' Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects ', Nature Medicine . https://doi.org//10.1038/s41591-022-01
Clonal hematopoiesis of indeterminate potential (CHIP) increases rapidly in prevalence beyond age 60 and has been associated with increased risk for malignancy, heart disease and ischemic stroke. CHIP is driven by somatic mutations in hematopoietic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd25b8355b18f6e8a1aa4dca9cf5921
https://hdl.handle.net/20.500.11820/d320a934-2275-4125-b5c6-126fd2be9f62
https://hdl.handle.net/20.500.11820/d320a934-2275-4125-b5c6-126fd2be9f62
Autor:
Christos Kiourtis, Maria Terradas-Terradas, Lucy M. Gee, Ya-Ching Hsieh, Colin Nixon, William Clark, Robin Shaw, Peter S. Hanson, David Sumpton, Gillian Mackay, Stephanie May, Miryam Müller, Arafath K. Najumudeen, Andrew Campbell, Simon T. Barry, Christopher M. Morris, Fiona E. N. LeBeau, Owen J. Sansom, Kristina Kirschner, Fiona Oakley, Thomas G. Bird
Cellular senescence is associated with aging but also impacts various physiological and pathological processes such as embryonic development and wound healing. Factors secreted by senescent cells can affect their microenvironment, including local spr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2017462eefc336f5e042d4ea9ff8df0
https://doi.org/10.21203/rs.3.rs-1133747/v1
https://doi.org/10.21203/rs.3.rs-1133747/v1
Autor:
Neil A, Robertson, Eric, Latorre-Crespo, Maria, Terradas-Terradas, Jorge, Lemos-Portela, Alison C, Purcell, Benjamin J, Livesey, Robert F, Hillary, Lee, Murphy, Angie, Fawkes, Louise, MacGillivray, Mhairi, Copland, Riccardo E, Marioni, Joseph A, Marsh, Sarah E, Harris, Simon R, Cox, Ian J, Deary, Linus J, Schumacher, Kristina, Kirschner, Tamir, Chandra
Publikováno v:
Nature medicine. 28(7)
Clonal hematopoiesis of indeterminate potential (CHIP) increases rapidly in prevalence beyond age 60 and has been associated with increased risk for malignancy, heart disease and ischemic stroke. CHIP is driven by somatic mutations in hematopoietic s
Publikováno v:
Experimental Hematology. 111:S120
Autor:
Andrew Davis, Helen Stewart, Kristina Kirschner, Tessa L. Holyoake, William C. Clark, Ashley Newcombe, Xu Huang, John J. Cole, Anne-Louise Latif, Joana Campos, Stephen W.G. Tait, Kevin M. Ryan, Lynn McGarry, Loveena Rishi, Claire Reid, Jun-ichi Sakamaki, Sheela A. Abraham, Brian Higgins, Claire McKeeve, Xue Lei, Neil Robertson, Karen Blyth, Jennifer P. Morton, Timothy Chevassut, Mhairi Copland, Jonathan Lopez, Kathryn Gilroy, Karen Keeshan, Peter D. Adams, Sha Li, Maria Terradas Terradas
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Acute myeloid leukemia (AML) is a typically lethal molecularly heterogeneous disease, with few broad-spectrum therapeutic targets. Unusually, most AML retain wild-type TP53, encoding the pro-apoptotic tumor suppressor p53. MDM2 inhibitors (MDM2i), wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813a0a41aaea00f9398f4b139324ead4
https://doi.org/10.1101/2020.09.16.291930
https://doi.org/10.1101/2020.09.16.291930
Publikováno v:
Mechanisms of Ageing and Development
Highlights • Somatic driver mutations lead to clonal haematopoiesis of indeterminate potential (CHIP) in aged haematopoietic stem cells. • CHIP is associated with a variety of age-related multimorbidities. • How environmental and cell-intrinsic
Autor:
Maria Terradas-Terradas, Neil Robertson, Eric Latorre-Crespo, alison Purcell, Linus schumacher, Alba Rodriguez-meira, Sarah Harris, Simon Cox, Ian Deary, Joanna baxter, Mhairi Copland, Adam Mead, Tamir Chandra, Kristina Kirschner
Publikováno v:
Experimental Hematology. 100:S105
Autor:
Kristina Kirschner, Neil Robertson, Eric Latorre-Crespo, Alison Purcell, Maria Terradas-Terradas, Angela Fawkes, Louise MacGillivray, Lee Murphy, Joseph Marsh, mhairi Copland, Riccardo Marioni, Sarah Harris, Ian Deary, Cox Simon, Linus Schumacher, Tamir Chandra
Publikováno v:
Experimental Hematology. 100:S81
Autor:
John J. Cole, Neil Robertson, Anne-Louise Latif, Andrew Davis, Jonathan Lopez, Lynn McGarry, Tessa L. Holyoake, Karen Keeshan, Claire Reid, Aniruddha J. Deshpande, Peter D. Adams, Kathryn Gilrory, Kristina Kirschner, Karen Blyth, Ashley Newcombe, Karina Barbosa, Loveena Rishi Delori, Mhairi Copland, Timothy Chevassut, Sheela A. Abraham, Xu Huang, Helen Stewart, William C. Clark, Stephen W.G. Tait, Xue Lei, Darren Finlay, Kevin M. Ryan, Jennifer P. Morton, Sha Li, Joana Campos, Maria Terradas Terradas, Claire McKeeve, Jun-ichi Sakamaki, Brian Higgins
Publikováno v:
Blood. 136:14-14
Acute Myeloid Leukemia (AML) is a typically-lethal molecularly heterogeneous disease, with few broad-spectrum therapeutic targets. Unusually compared to many other cancers, over 90% of AML patients retain wild type TP53, encoding pro-apoptotic tumor