Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Maria Teresa Bernabei"'
Autor:
Gilberto Coppi, Valentina Iannuccelli, Maria Teresa Bernabei, Eliana Grazia Leo, Riccardo Cameroni
Publikováno v:
Journal of Microencapsulation. 19:37-44
Oral administration of peptide and protein drugs requires their protection from the acidic and enzymatic degradation in the gastro-intestinal environment and their targeting to the absorption zone. For this purpose, an alginate microsystem, as a carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cdf8eae42d9a02b3a188e69a92f9614
https://doi.org/10.1080/02652040110055621
https://doi.org/10.1080/02652040110055621
Publikováno v:
International Journal of Pharmaceutics. 196:1-9
The preparation, characterisation and drug release behaviour of ibuprofen loaded poly( d , l -lactic acid) (PLA) microspheres are described. Depending on the gelatin concentration in the aqueous external solution (1, 0.5, 0.1% w/v), microspheres with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc475b3fe9988abc643ce089f3d566d
https://doi.org/10.1016/s0378-5173(99)00335-x
https://doi.org/10.1016/s0378-5173(99)00335-x
Autor:
Maria Angela Vandelli, Maria Teresa Bernabei, Valentina Iannuccelli, Gilberto Coppi, Eliana Grazia Leo
Publikováno v:
Drug Development and Industrial Pharmacy. 21:2307-2322
Coated beads were prepared by soaking in sodium alginate solutions spherical matrices (beads) of carboxymethylcellulose crosslinked with aluminum chloride (AlCl3) and loaded with ambroxol hydrochloride as a model drug. The residual amount of the cros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44772ef3c21da415ae90415378fc9da8
https://doi.org/10.3109/03639049509070871
https://doi.org/10.3109/03639049509070871
Publikováno v:
Journal of Controlled Release. 23:13-20
Spherical matrices (beads) of cross-linked carboxymethylcellulose were prepared by the in-liquid curing coating process using AlCl3 as curing agent (cross-linker). The loading process was carried out either by adding the drug to the polymer solutions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0a005f4ac88746bdbcac6fec53fc41
https://doi.org/10.1016/0168-3659(93)90066-e
https://doi.org/10.1016/0168-3659(93)90066-e
In order to protect protein and peptide drugs against inactivation by different barriers in the gastro-intestinal tract and to improve their absorption, alginate microparticles as a carrier of L-lactate dehydrogenase, were developed by spray-drying t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b4f59211acef04877400174ca58b7d
https://hdl.handle.net/11380/305597
https://hdl.handle.net/11380/305597
Autor:
Maria Teresa Bernabei, Eliana Grazia Leo, Riccardo Cameroni, Gilberto Coppi, Valentina Iannuccelli
Publikováno v:
ResearcherID
The oral administration of peptidic drugs requires their protection from degradation in the gastric environment and the improvement of their absorption in the intestinal tract. For these requirements, a microsystem based on cross-linked alginate as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9610a368adaa89368329bc168d3439e5
https://hdl.handle.net/11380/306520
https://hdl.handle.net/11380/306520
The poor bioavailability of orally dosed furosemide (FUR) is due to the presence of a biological window in the upper gastrointestinal tract. The purpose of the present study was to develop and optimize in vitro a multiple-unit floating system with in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684b035e064c461402c7503a834a4464
https://hdl.handle.net/11380/22130
https://hdl.handle.net/11380/22130
A pre-formulation study was directed to optimize the in vitro floating ability of an air compartment multiple-unit system. Each unit was formed by a coated bead composed of a calcium alginate core separated by an air compartment from a calcium algina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ab41deb93527f37f1f2e573af18fe9
https://hdl.handle.net/11380/307528
https://hdl.handle.net/11380/307528
Salbutamol sulfate microcapsules were prepared by a spray-drying technique. The release data were calculated approximately via standard equations (square root and first-order relationships), but unequivocal evidence in support of the cumulative relea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9541665c7e43d317ac594bda461888d1
https://hdl.handle.net/11380/305052
https://hdl.handle.net/11380/305052
Autor:
Maria Teresa Bernabei, Maria Angela Vandelli, Flavio Forni, Gilberto Coppi, Valentina Iannuccelli
Publikováno v:
Drug Development and Industrial Pharmacy. 14:633-647
By grinding, chloramphenicol stearate Form III turns into Form I: then this form tends to become amorphous. So the grinding of both forms produces a “physically activated” form (FI*) with low crystallinity degree and high CAP availability. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3fd0be9ad02e2fd012796b0031e2ba
https://doi.org/10.3109/03639048809151890
https://doi.org/10.3109/03639048809151890