Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Maria T. Villar"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 1, Pp 39-59 (2023)
Background & Aims: Alcohol-associated liver disease (ALD) comprises a spectrum of disorders including steatosis, steatohepatitis, fibrosis, and cirrhosis. We aimed to study the role of protein arginine methyltransferase 6 (PRMT6), a new regulator of
Externí odkaz:
https://doaj.org/article/b3fd6441e4e84cd5b53fa3e81ad3b00d
Publikováno v:
Hepatology Communications, Vol 5, Iss 5, Pp 812-829 (2021)
Protein arginine methyl transferase 1 (PRMT1) is the main enzyme for cellular arginine methylation. It regulates many aspects of liver biology including inflammation, lipid metabolism, and proliferation. Previously we identified that PRMT1 is necessa
Externí odkaz:
https://doaj.org/article/21275645364f4de099762dd1e6ac4ee0
Autor:
Rajan A. Burt, Ibtihal M. Alghusen, Sophiya John Ephrame, Maria T. Villar, Antonio Artigues, Chad Slawson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
O-GlcNAc is a pleotropic, enigmatic post-translational modification (PTM). This PTM modifies thousands of proteins differentially across tissue types and regulates diverse cellular signaling processes. O-GlcNAc is implicated in numerous diseases, and
Externí odkaz:
https://doaj.org/article/fb8e90d1223d45bb9aa50d239ea75abf
Publikováno v:
Cellular and molecular gastroenterology and hepatology. 15(1)
Alcohol-associated liver disease (ALD) comprises a spectrum of disorders including steatosis, steatohepatitis, fibrosis, and cirrhosis. We aimed to study the role of protein arginine methyltransferase 6 (PRMT6), a new regulator of liver function, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c2534828ba72e4b4e3063108577fe0
https://pubmed.ncbi.nlm.nih.gov/36191854
https://pubmed.ncbi.nlm.nih.gov/36191854
Autor:
Maura O'Neil, Steven A Weinman, Antonio Artigues, Janice Averilla, Maria T. Villar, Sumedha Gunewardena, Michael Schonfeld, Irina Tikhanovich
Publikováno v:
Alcohol Clin Exp Res
Background Mouse models of alcohol-associated liver disease vary greatly in their ease of implementation and the pathology they produce. This ranges from steatosis and mild inflammation in Lieber-DeCarli liquid diet, and severe inflammation, fibrosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384b8a8426ab3e8866487a0fcb798249
https://europepmc.org/articles/PMC9006178/
https://europepmc.org/articles/PMC9006178/
Autor:
Todd A. Lydic, Harmony Saunders, Patrick E. Fields, Ee Phie Tan, Gentry K. Cork, Jibiao Li, Maria T. Villar, Chad Slawson, Zhen Zhang, Miranda Machacek, Antonio Artigues, Tiangang Li
Publikováno v:
Journal of Biological Chemistry. 294:8973-8990
Chronic, low-grade inflammation increases the risk for atherosclerosis, cancer, and autoimmunity in diseases such as obesity and diabetes. Levels of CD4+ T helper 17 (Th17) cells, which secrete interleukin 17A (IL-17A), are increased in obesity and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ef6cd46da272ffb95a3f5a4b0ec67f3
https://doi.org/10.1074/jbc.ra119.008373
https://doi.org/10.1074/jbc.ra119.008373
Publikováno v:
Proceedings of the National Academy of Sciences. 114:7497-7504
In Escherichia coli MinE induces MinC/MinD to oscillate between the ends of the cell, contributing to the precise placement of the Z ring at midcell. To do this, MinE undergoes a remarkable conformational change from a latent 6β-stranded form that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae85d7f83075d3730a5d63ae6f8fe9bb
https://doi.org/10.1073/pnas.1707385114
https://doi.org/10.1073/pnas.1707385114
Autor:
Aron W. Fenton, Qingling Tang, Hao Zhu, Maria T. Villar, Udayan Apte, Kenneth R. Peterson, John P. Thyfault, Antonio Artigues
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Development of drugs that allosterically regulate enzyme functions to treat disease is a costly venture. Screening mutations that mimic allosteric effectorsin vitrowill identify therapeutic regulatory targets enhancing the likelihood of developing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0baaeebad61c3909f7103aec46220960
http://europepmc.org/articles/PMC6588628
http://europepmc.org/articles/PMC6588628
Autor:
Miranda, Machacek, Harmony, Saunders, Zhen, Zhang, Ee Phie, Tan, Jibiao, Li, Tiangang, Li, Maria T, Villar, Antonio, Artigues, Todd, Lydic, Gentry, Cork, Chad, Slawson, Patrick E, Fields
Publikováno v:
J Biol Chem
Chronic, low-grade inflammation increases the risk for atherosclerosis, cancer, and autoimmunity in diseases such as obesity and diabetes. Levels of CD4(+) T helper 17 (Th17) cells, which secrete interleukin 17A (IL-17A), are increased in obesity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fda90ed587fc344ff2d4b4e80e3ac5f
https://pubmed.ncbi.nlm.nih.gov/31010828
https://pubmed.ncbi.nlm.nih.gov/31010828
Autor:
Bradley L. Pentelute, Alexandra J Machen, Mark T. Fisher, Pierce T. O’Neil, Maria T. Villar, Antonio Artigues
Publikováno v:
Journal of Visualized Experiments (JOVE)
In vivo, proteins are often part of large macromolecular complexes where binding specificity and dynamics ultimately dictate functional outputs. In this work, the pre-endosomal anthrax toxin is assembled and transitioned into the endosomal complex. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b4cfa3b43b0b8417f70f6902dc3aa5
https://doi.org/10.3791/57902-v
https://doi.org/10.3791/57902-v