Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Maria T. Valentine"'
Publikováno v:
Atherosclerosis. 149:323-330
Atherosclerosis and the expression of monocyte chemoattractant protein-1 (MCP-1) were quantified in low density lipoprotein receptor knockout (LDLR KO) mice fed 1.25% cholesterol (study #1) or 0.2% cholesterol (study #2). In study #1 plasma total cho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65be7ccbb27371fa3dd2415828186ea2
https://doi.org/10.1016/s0021-9150(99)00342-1
https://doi.org/10.1016/s0021-9150(99)00342-1
Autor:
Peter H. Gitlitz, Takao Kurihara, Mary Giancarli, Mark C. Kowala, Stephen K. Durham, Michele H. French, J.Eileen Bird, Maria T. Valentine, Darshana G. Pandya
Publikováno v:
Kidney International. 57:129-136
Increased severity of glomerulonephritis in C-C chemokine receptor 2 knockout mice. Background The C-C chemokine receptor 2 (CCR2) is expressed on monocytes and facilitates monocyte migration. CCR2 is a prominent receptor for monocyte chemoattractant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5f3123ab4d3cfaf01d4e8f2f6b7f88
https://doi.org/10.1046/j.1523-1755.2000.00848.x
https://doi.org/10.1046/j.1523-1755.2000.00848.x
Autor:
Jay L. Degen, Qing Xiao, Maria T. Valentine, David P. Witte, Mark C. Kowala, Thomas H. Bugge, Mary Jo S. Danton
Publikováno v:
Proceedings of the National Academy of Sciences. 94:10335-10340
A critical link between hemostatic factors and atherosclerosis has been inferred from a variety of indirect observations, including the expression of procoagulant and fibrinolytic factors within atherosclerotic vessels, the presence of fibrin in inti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1e6b206b9c93f0acbdafaede232fa1
https://doi.org/10.1073/pnas.94.19.10335
https://doi.org/10.1073/pnas.94.19.10335
Autor:
Maria T. Valentine, Nancy L. Goller, Tonya Jenkins-West, Stephen K. Durham, Helen Weber, Patricia Ferrer, Christopher J. Molloy, Suzanne Moreland
Publikováno v:
Scopus-Elsevier
Vascular smooth muscle cell (SMC) proliferation is an important component in the development of restenosis. Because endothelin (ET) has been reported to act as an SMC mitogen, we postulated that the orally active ET A receptor antagonist BMS-182874 w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfa4462af2e4e13d0b3617076af6985
https://doi.org/10.1097/00005344-199512000-00009
https://doi.org/10.1097/00005344-199512000-00009
Publikováno v:
Journal of Histotechnology. 20:61-63
We modified and automated a conventional hematoxylin and eosin stain for formalin fixed, paraffin embedded rat carotid and pig coronary arteries. This method enhanced the staining of the elastic laminae in injured pig coronary and rat carotid arterie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b07010c9008ba7b1889fa28d089a4f22
https://doi.org/10.1179/his.1997.20.1.61
https://doi.org/10.1179/his.1997.20.1.61
Autor:
Maria T. Valentine, Natesan Murugesan, Yifan Yang, Leena Fadnis, W. Griffith Humphreys, Robert Zahler, Shih-Jung Lan, William R. Ewing, John E. Macor, Kenneth E. Carlson, Rose Ann F Baska, Kenneth E.J. Dickinson, Hossain Monshizadegan, Mark C. Kowala, John E. Tellew, Zhengxiang Gu, Sophie Beyer
Publikováno v:
Journal of medicinal chemistry. 48(1)
In a previous report we demonstrated that merging together key structural elements present in an AT(1) receptor antagonist (1, irbesartan) with key structural elements in a biphenylsulfonamide ET(A) receptor antagonist (2) followed by additional opti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd91f0561a787952e7b333f7c8ed5d7
https://pubmed.ncbi.nlm.nih.gov/15634011
https://pubmed.ncbi.nlm.nih.gov/15634011
Autor:
Maria T. Valentine, Natesan Murugesan, John E. Tellew, Sophie Beyer, John E. Macor, Yifan Yang, Zhengxiang Gu, Cornelius Lyndon A M, Mark C. Kowala, Bridgette L. Kunst, Leena Fadnis, Carol S. Ryan, Hossain Monshizadegan, Kenneth E. Carlson, Rose Ann F Baska
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(6)
A series of 4'-[(imidazol-1-yl)methyl]biphenylsulfonamides has potent antagonist activity against both angiotensin II AT(1) and endothelin ET(A) receptors. Such dual-acting antagonists could have utility in the treatment of hypertension, heart failur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f7d5f1255b7159594f4dc305daa1d6
https://pubmed.ncbi.nlm.nih.gov/12643919
https://pubmed.ncbi.nlm.nih.gov/12643919
Autor:
John E. Tellew, Rose Ann F Baska, Cornelius Lyndon A M, Zhengxiang Gu, Kenneth E. Carlson, Richard A. Morrison, Maria T. Valentine, John E. Macor, Kenneth E.J. Dickinson, James R. Powell, Natesan Murugesan, Sophie Beyer, Yifan Yang, Balkrushna C. Panchal, Mark C. Kowala, Bridgette L. Kunst, Suzanne Moreland, Joel C. Barrish, Leena Fadnis, Hossain Monshizadegan, Saeho Chong
Publikováno v:
Journal of medicinal chemistry. 45(18)
The ET(A) receptor antagonist (2) (N-(3,4-dimethyl-5-isoxazolyl)-4'-(2-oxazolyl)-[1,1'-biphenyl]-2-sulfonamide, BMS-193884) shares the same biphenyl core as a large number of AT(1) receptor antagonists, including irbesartan (3). Thus, it was hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d290d753aaf45a873c5aab647be930
https://pubmed.ncbi.nlm.nih.gov/12190306
https://pubmed.ncbi.nlm.nih.gov/12190306
Autor:
Mark C. Kowala, Michael A. Poss, Mark A. Hermsmeier, Maria T. Valentine, Thomas J. Caulfield, Richard D. Cramer
Publikováno v:
Journal of medicinal chemistry. 42(19)
The principle of bioisosterism-similarly shaped molecules are more likely to share biological properties than are other molecules-has long helped to guide drug discovery. An algorithmic implementation of this principle, based on shape comparisons of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df78b1eb95910d0252f9701584dab54
https://pubmed.ncbi.nlm.nih.gov/10508440
https://pubmed.ncbi.nlm.nih.gov/10508440
Autor:
Nancy L. Goller, Sophie Beyer, Gunnar Aberg, Stephen K. Durham, Maria T. Valentine, Ron Recce, Mark C. Kowala
Publikováno v:
Journal of cardiovascular pharmacology. 32(1)
Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase and angiotensin-converting enzyme (ACE) reduce experimental atherosclerosis by different mechanisms. To determine whether dual-drug therapy additively retards the progression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9f18d929b07b9f311907cd41e8fe07
https://pubmed.ncbi.nlm.nih.gov/9676717
https://pubmed.ncbi.nlm.nih.gov/9676717