Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Maria T. Georgescu"'
Autor:
Maria T. Georgescu, Paul C. Moorehead, Tongyao Liu, Jennifer Dumont, David W. Scott, Christine Hough, David Lillicrap
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The development of neutralizing antibodies (inhibitors) against factor VIII (FVIII) is a major complication of hemophilia A treatment. The sole clinical therapy to restore FVIII tolerance in patients with inhibitors remains immune tolerance induction
Externí odkaz:
https://doaj.org/article/a2ee070406e647a2aa15fff3c1819720
Autor:
Maria T. Georgescu, Paul C. Moorehead, Alice S. van Velzen, Kate Nesbitt, Birgit M. Reipert, Katharina N. Steinitz, Maria Schuster, Christine Hough, David Lillicrap
Publikováno v:
Haematologica, Vol 103, Iss 8 (2018)
The development of inhibitory antibodies to factor VIII is the most serious complication of replacement therapy in hemophilia A. Activation of the innate immune system during exposure to this protein contributes to inhibitor development. However, avo
Externí odkaz:
https://doaj.org/article/795636410fc144f29549cf2ed3ff147e
Autor:
Kate Nesbitt, Katharina Nora Steinitz, Birgit M. Reipert, Alice S. van Velzen, Paul Moorehead, Christine Hough, David Lillicrap, Maria Schuster, Maria T. Georgescu
Publikováno v:
Haematologica, 103(8), 1403-1413. Ferrata Storti Foundation
Haematologica
Haematologica
The development of inhibitory antibodies to factor VIII is the most serious complication of replacement therapy in hemophilia A. Activation of the innate immune system during exposure to this protein contributes to inhibitor development. However, avo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa0b4c50cdf2fb3c8d986c7ec9d413e
https://pure.amc.nl/en/publications/dexamethasone-promotes-durable-factor-viiispecific-tolerance-in-hemophilia-a-mice-via-thymic-mechanisms(5cff90a1-e722-419f-a1e0-067bc16d2484).html
https://pure.amc.nl/en/publications/dexamethasone-promotes-durable-factor-viiispecific-tolerance-in-hemophilia-a-mice-via-thymic-mechanisms(5cff90a1-e722-419f-a1e0-067bc16d2484).html
Publikováno v:
Cellular immunology. 301
The development of neutralizing anti-factor VIII (FVIII) antibodies (inhibitors) remains a major challenge for FVIII replacement therapy in hemophilia A patients. The adaptive immune response plays a crucial role in the development and maintenance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b11c02d59cba6874171930eff7510b
https://pubmed.ncbi.nlm.nih.gov/26676073
https://pubmed.ncbi.nlm.nih.gov/26676073
Publikováno v:
Cellular Immunology
Highlights • FVIII inhibitor development involves a combination of innate immune modulators. • Clearance and immunity is influenced at 3 levels: the protein, cell, and location. • Cells associated with FVIII half-life may influence the immune r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6bb9758c25ea6be799f0116c3c0d399
https://pubmed.ncbi.nlm.nih.gov/26547364
https://pubmed.ncbi.nlm.nih.gov/26547364
Autor:
David Lillicrap, Christine Hough, Barbara Vidal, Paul Moorehead, Maria T. Georgescu, Alice S. van Velzen, Birgit M. Reipert, Kate Sponagle, Katharina Nora Steinitz
Publikováno v:
Blood. 124:1489-1489
Background For persons with severe hemophilia A receiving exogenous factor VIII (FVIII) replacement therapy, antibodies that interfere with the coagulant function of FVIII (inhibitors) are the most severe complication of treatment. Although avoidance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9648a1b21b599b62ef9ab1995807e264
https://doi.org/10.1182/blood.v124.21.1489.1489
https://doi.org/10.1182/blood.v124.21.1489.1489
Autor:
Paul Moorehead, Birgit M. Reipert, David Lillicrap, Christine Hough, Maria T. Georgescu, Kate Sponagle
Publikováno v:
Blood. 124:237-237
Background: The most severe complication of hemophilia A (HA) treatment is the development of inhibitory antibodies (inhibitors) to factor VIII (FVIII). The presence of immunological ‘danger signals’ during initial exposure to FVIII may increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94c21638cd646a23293ef4ec50a4e181
https://doi.org/10.1182/blood.v124.21.237.237
https://doi.org/10.1182/blood.v124.21.237.237