Výsledky vyhledávání - "Maria T Mora"

Akademický článek

Mechanistic investigation of Ca2+ alternans in human heart failure and its modulation by fibroblasts.

Autor: Maria T Mora, Juan F Gomez, Gregory Morley, Jose M Ferrero, Beatriz Trenor

Publikováno v: PLoS ONE, Vol 14, Iss 6, p e0217993 (2019)

BackgroundHeart failure (HF) is characterized, among other factors, by a progressive loss of contractile function and by the formation of an arrhythmogenic substrate, both aspects partially related to intracellular Ca2+ cycling disorders. In failing

Externí odkaz: https://doaj.org/article/5afef8d64cf147aea55c12fba4d22975

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Akademický článek

Sensitivity analysis revealing the effect of modulating ionic mechanisms on calcium dynamics in simulated human heart failure.

Autor: Maria T Mora, Jose M Ferrero, Lucia Romero, Beatriz Trenor

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0187739 (2017)

Abnormal intracellular Ca2+ handling is the major contributor to the depressed cardiac contractility observed in heart failure. The electrophysiological remodeling associated with this pathology alters both the action potential and the Ca2+ dynamics,

Externí odkaz: https://doaj.org/article/f875c42acda34139bc90bc7b2adf9935

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BS-452759-3 A NOVEL IN SILICO PHARMACOKINETIC/ELECTROPHYSIOLOGICAL MODELING FRAMEWORK TO ASSESS THE INFLUENCE OF SEX AND RENAL STATUS ON DRUG-INDUCED ARRHYTHMOGENICITY

Autor: Jordi Llopis-Lorente, Samuel Baroudi, Kévin Koloskoff, Maria T. Mora, Lucia Romero, Sylvain Benito, Javier Saiz, Beatriz Trenor

Publikováno v: Heart Rhythm. 20:S67-S68

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcfa9534772b811268761e17a0f876f9
https://doi.org/10.1016/j.hrthm.2023.03.342

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Omecamtiv Mecarbil Improves Contraction Behaviour in a 3D Electromechanical Tissue Model of Heart Failure

Autor: 'Ilse van Herck, Maria T Mora, Jordi Llopis-Lorente, Henrik Finsberg, Cécile Daversin-Catty, Javier Saiz, Beatriz Trenor, Hermenegild Arevalo, Samuel Wall\\'

Publikováno v: Computing in Cardiology Conference (CinC).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfe86f98e2dee1ad4a767cf5b3d75dff
https://doi.org/10.22489/cinc.2022.033

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The role of beta-adrenergic system remodeling in human heart failure: A mechanistic investigation

Autor: Eric A. Sobie, Maria T. Mora, Beatriz Trenor, Jingqi Q.X. Gong

Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname

[EN] ß-adrenergic receptor antagonists (ß-blockers) are extensively used to improve cardiac performance in heart failure (HF), but the electrical improvements with these clinical treatments are not fully understood. The aim of this study was to ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde69905011948f9fadf8e65f1fbb6ef
https://hdl.handle.net/10251/163196

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Reduced Myofilament Contraction in Human Heart Failure. Insights From Electromechanical Simulations

Autor: Sofia Gutierrez, Albert Dasi, Maria T. Mora, Beatriz Trenor, Juan F. Gomez

Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
CinC

[EN] Intracellular Ca2+ is the main activator of myofilament contraction and the altered Ca2+ handling observed in failing cells has been established as the leading cause of reduced inotropy in heart failure. Electrophysiological studies usually quan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bec331224bb5e7e128e3cb1c51faf9d

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Fibroblasts Induce Calcium Alternans When Coupled to Cardiomyocytes: A Simulation Study

Autor: Maria T. Mora, Jose M Ferrero, Beatriz Trenor, Javier Saiz, Albert Dasi

Publikováno v: CinC

Cardiac alternans has been linked to arrhythmias, and certain conditions, such as fibrosis, can change the onset of alternans increasing the vulnerability to electrical instabilities. The study of the underlying mechanisms of beat-to-beat cellular fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81cbee241f44e951236336337de0f25c
https://doi.org/10.22489/cinc.2018.140

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Ca2+ Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations

Autor: Jose M Ferrero, Beatriz Trenor, Eric A. Sobie, Juan F. Gomez, Maria T. Mora

Publikováno v: Frontiers in Physiology, Vol 9 (2018)
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
Frontiers in Physiology

[EN] Heart failure (HF) is characterized by altered Ca2+ cycling, resulting in cardiac contractile dysfunction. Failing myocytes undergo electrophysiological remodeling, which is known to be the main cause of abnormal Ca2+ homeostasis. However, struc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aee56af0b384db83ab5990188508501
https://www.frontiersin.org/article/10.3389/fphys.2018.01194/full

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Ionic Modulation of Calcium Dynamics in Simulated Human Heart Failure

Autor: Jose M Ferrero, Maria T. Mora, Beatriz Trenor

Publikováno v: CinC

Calcium mishandling observed in failing hearts is responsible for contractile dysfunction and arrhythmias. Thereby, calcium dynamics becomes an important target to explore for the restoration of the altered excitation-contraction coupling. In this st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cea9edbeb9ff13f056e25d8e6e70580
https://doi.org/10.22489/cinc.2017.248-074

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Sensitivity analysis revealing the effect of modulating ionic mechanisms on calcium dynamics in simulated human heart failure

Autor: Lucia Romero, Jose M Ferrero, Beatriz Trenor, Maria T. Mora

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0187739 (2017)
PLoS ONE
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname

[EN] Abnormal intracellular Ca2+ handling is the major contributor to the depressed cardiac contractility observed in heart failure. The electrophysiological remodeling associated with this pathology alters both the action potential and the Ca2+ dyna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12920e8fbf7a61b93514e744ec6ea32b
https://doi.org/10.1371/journal.pone.0187739

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