SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damage.

Autor: Sonia Brun, Neus Abella, Maria T Berciano, Olga Tapia, Montserrat Jaumot, Raimundo Freire, Miguel Lafarga, Neus Agell

Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0178925 (2017)

We previously showed that p21Cip1 transits through the nucleolus on its way from the nucleus to the cytoplasm and that DNA damage inhibits this transit and induces the formation of p21Cip1-containing intranucleolar bodies (INoBs). Here, we demonstrat

Externí odkaz: https://doaj.org/article/f610d724676444bf8137644f458fc2ba

Compensatory motor neuron response to chromatolysis in the murine hSOD1G93A model of amyotrophic lateral sclerosis

Autor: Javier eRiancho, Maria eRuiz-Soto, Nuria T Villagra, Jose eBerciano, Maria T Berciano, Miguel eLafarga

Publikováno v: Frontiers in Cellular Neuroscience, Vol 8 (2014)

We investigated neuronal self-defense mechanisms in a murine model of amyotrophic lateral sclerosis (ALS), the transgenic hSOD1G93A, during both the asymptomatic and symptomatic stages. This is an experimental model of endoplasmic reticulum (ER) stre

Externí odkaz: https://doaj.org/article/6076f0980ace43dfa94c7dd07722fde0

Hsp70 chaperones and type I PRMTs are sequestered at intranuclear inclusions caused by polyalanine expansions in PABPN1.

Autor: João Paulo Tavanez, Rocio Bengoechea, Maria T Berciano, Miguel Lafarga, Maria Carmo-Fonseca, Francisco J Enguita

Publikováno v: PLoS ONE, Vol 4, Iss 7, p e6418 (2009)

Genomic instability at loci with tandem arrays of simple repeats is the cause for many neurological, neurodegenerative and neuromuscular diseases. When located in coding regions, disease-associated expansions of trinucleotide repeats are translated i

Externí odkaz: https://doaj.org/article/e9596f8e4200445da3e8105d9a03841f

Nucleolin reorganization and nucleolar stress in Purkinje cells of mutant PCD mice

Autor: Eduardo Weruaga, Olga Tapia, Fernando C. Baltanás, Vanesa Lafarga, Maria T. Berciano, Josep Oriol Narcís, Miguel Lafarga, David Díaz, Eugenio Santos

Publikováno v: Neurobiology of Disease, Vol 127, Iss, Pp 312-322 (2019)
Neurobiol Dis. 2019 July;127:312-322
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Digital.CSIC. Repositorio Institucional del CSIC
instname

The Purkinje cell (PC) degeneration (pcd) mouse harbors a mutation in Agtpbp1 gene that encodes for the cytosolic carboxypeptidase, CCP1. The mutation causes degeneration and death of PCs during the postnatal life, resulting in clinical and pathologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4d0065d3154b861fb050a07a75dedf
http://www.sciencedirect.com/science/article/pii/S0969996119300713

Nuclear Reorganization in Hippocampal Granule Cell Neurons from a Mouse Model of Down Syndrome: Changes in Chromatin Configuration, Nucleoli and Cajal Bodies

Autor: Olga Tapia, Alba Puente-Bedia, Noemí Rueda, Carmen Martínez-Cué, Maria T. Berciano, Miguel Lafarga

Publikováno v: International Journal of Molecular Sciences
Int. J. Mol. Sci. 2021, 22(3), 1259
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1259, p 1259 (2021)

Down syndrome (DS) or trisomy of chromosome 21 (Hsa21) is characterized by impaired hippocampal-dependent learning and memory. These alterations are due to defective neurogenesis and to neuromorphological and functional anomalies of numerous neuronal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c02973cf413206e3f9113ee4f956137
http://europepmc.org/articles/PMC7865916