Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Maria Stavrou"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Macrophages represent an immune cell population characterized by high plasticity and a range of properties and functions. Their activation status and specific phenotype are highly associated with their localization and the environmental cues they rec
Externí odkaz:
https://doaj.org/article/4d635c4a21b34a9b8bb7e22201c3429d
Autor:
Ramona N. Moro, Uddipta Biswas, Suhas S. Kharat, Filip D. Duzanic, Prosun Das, Maria Stavrou, Maria C. Raso, Raimundo Freire, Arnab Ray Chaudhuri, Shyam K. Sharan, Lorenza Penengo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract DNA replication and repair defects or genotoxic treatments trigger interferon (IFN)-mediated inflammatory responses. However, whether and how IFN signaling in turn impacts the DNA replication process has remained elusive. Here we show that b
Externí odkaz:
https://doaj.org/article/64183fd52790466eb0edc4131fa2fe97
Autor:
Julia Taylor, Anna Bulek, Isaac Gannon, Mathew Robson, Evangelia Kokalaki, Thomas Grothier, Callum McKenzie, Mohamed El-Kholy, Maria Stavrou, Charlotte Traynor-White, Wen Chean Lim, Panagiota Panagiotou, Saket Srivastava, Vania Baldan, James Sillibourne, Mathieu Ferrari, Martin Pule, Simon Thomas
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
SHP1 and SHP2 are SH2 domain-containing proteins which have inhibitory phosphatase activity when recruited to phosphorylated ITIMs and ITSMs on inhibitory immune receptors. Consequently, SHP1 and SHP2 are key proteins in the transmission of inhibitor
Externí odkaz:
https://doaj.org/article/e38d52e6c99944609c3459b7f08fd187
Autor:
Alexander N. Kapustin, Paul Davey, David Longmire, Carl Matthews, Emily Linnane, Nitin Rustogi, Maria Stavrou, Paul W. A. Devine, Nicholas J. Bond, Lyndsey Hanson, Silvia Sonzini, Alexey Revenko, A. Robert MacLeod, Sarah Ross, Elisabetta Chiarparin, Sanyogitta Puri
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Kapustin et al. investigate the intracellular trafficking of anti-KRAS antisense oligonucleotides. They show that the oligonucleotide AZD4785 is recycled via late endosomes in extracellular vesicles in both cells with poor and good oligo productive u
Externí odkaz:
https://doaj.org/article/e4d7d13e7cd04080b03cedf4614a86e6
Autor:
Jeremy Chataway, Suvankar Pal, Charis Wong, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Judith Newton, Shuna Colville, Maria Stavrou, Christopher J Weir, Nigel Stallard, Malcolm R Macleod, Michelle Steven, Richard Anthony Parker, Arpan R Mehta, Robert J Swingler, Mahesh K B Parmar, Rachel S Dakin, Jill Williamson
Publikováno v:
BMJ Open, Vol 12, Iss 7 (2022)
Introduction Motor neuron disease (MND) is a rapidly fatal neurodegenerative disease. Despite decades of research and clinical trials there remains no cure and only one globally approved drug, riluzole, which prolongs survival by 2–3 months. Recent
Externí odkaz:
https://doaj.org/article/5e965243774d4c02bc888f34d9e8e037
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-4 (2020)
Abstract Background Meningitis is a very rare atypical presenting feature of anti-NMDA receptor encephalitis. In our case report, we describe an unusual clinical presentation of anti-NMDA receptor encephalitis with a biphasic pattern of meningitis fo
Externí odkaz:
https://doaj.org/article/0e9f6b61369d4759ac726f5054e727ea
Publikováno v:
BMJ Neurology Open, Vol 3, Iss 2 (2021)
Background Remote consulting is an emerging model in managing chronic neurological conditions and has been widely implemented during the COVID-19 pandemic. The objective of this national survey was to investigate the initial experiences of remote con
Externí odkaz:
https://doaj.org/article/23232eedcfaa4addbf7842bac392bacf
Publikováno v:
Case Reports in Psychiatry, Vol 2016 (2016)
Objective. Heart failure remains a major cause of morbidity and mortality. Given that heart failure generally has a chronic course, it is important to appreciate the impact it can have on the quality of life of patients and also their partners or fam
Externí odkaz:
https://doaj.org/article/77ec11b4409d4d71a50b4fbe6d2c0003
Publikováno v:
Journal of Orthopaedic Surgery, Vol 21 (2013)
Treatment for Achilles tendon ruptures in athletes is controversial. Surgical fixation has lower rates of rerupture and confers increased strength and function, whereas conservative treatment has lower risks of wound complications. We review the lite
Externí odkaz:
https://doaj.org/article/98dac599fb314a0099ddea65e1cceba7
Autor:
Charis Wong, Rachel S Dakin, Jill Williamson, Judith Newton, Michelle Steven, Shuna Colville, Maria Stavrou, Jenna M Gregory, Elizabeth Elliott, Arpan R Mehta, Jeremy Chataway, Robert J Swingler, Richard Anthony Parker, Christopher J Weir, Nigel Stallard, Mahesh K B Parmar, Malcolm R Macleod, Suvankar Pal, Siddharthan Chandran
Publikováno v:
Wong, C, Dakin, R S, Williamson, J, Newton, J, Steven, M, Colville, S, Stavrou, M, Gregory, J M, Elliott, E, Mehta, A R, Chataway, J, Swingler, R J, Parker, R A, Weir, C J, Stallard, N, Parmar, M K B, Macleod, M R, Pal, S & Chandran, S 2022, ' Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease ', BMJ Open, vol. 12, no. 7, pp. e064173 . https://doi.org/10.1136/bmjopen-2022-064173
IntroductionMotor neuron disease (MND) is a rapidly fatal neurodegenerative disease. Despite decades of research and clinical trials there remains no cure and only one globally approved drug, riluzole, which prolongs survival by 2–3 months. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741cf9191ecd078be98826980c974033
https://www.pure.ed.ac.uk/ws/files/285183479/e064173_MND_SMART.full.pdf
https://www.pure.ed.ac.uk/ws/files/285183479/e064173_MND_SMART.full.pdf