The genetic relationships between brain structure and schizophrenia

Autor: Eva-Maria Stauffer, Richard A. I. Bethlehem, Lena Dorfschmidt, Hyejung Won, Varun Warrier, Edward T. Bullmore

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Genetic risks for schizophrenia are theoretically mediated by genetic effects on brain structure but it has been unclear which genes are associated with both schizophrenia and cortical phenotypes. We accessed genome-wide association studies

Externí odkaz: https://doaj.org/article/68f40a8c72b140d1bef0a90f030cf8fc

Grey and white matter microstructure is associated with polygenic risk for schizophrenia

Autor: Edward T. Bullmore, Graham K. Murray, Jakob Seidlitz, Rafael Romero-Garcia, Richard A. I. Bethlehem, Varun Warrier, Eva-Maria Stauffer

Publikováno v: Molecular Psychiatry. 26:7709-7718

Recent discovery of approximately 270 common genetic variants associated with schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population. We hypothesized that normal variation in PRS would be associated with magnetic reson

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd25406877e2c0d6d18c040f64a33367
https://doi.org/10.1038/s41380-021-01260-5

Grey and white matter microstructure is associated with polygenic risk for schizophrenia

Autor: Eva-Maria, Stauffer, Richard A I, Bethlehem, Varun, Warrier, Graham K, Murray, Rafael, Romero-Garcia, Jakob, Seidlitz, Edward T, Bullmore

Publikováno v: Molecular psychiatry. 26(12)

Recent discovery of approximately 270 common genetic variants associated with schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population. We hypothesized that normal variation in PRS would be associated with magnetic reson

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eef5029ca3dbc87e5694276bd05f9ae6
https://pubmed.ncbi.nlm.nih.gov/34462574

Polygenic scores for autism are associated with neurite density in adults and children from the general population.

Autor: Gu Y; Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK., Maria-Stauffer E; Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH., Bedford SA; Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK., Romero-Garcia R; Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH.; Department of Medical Physiology and Biophysics, Instituto de Biomedicina de Sevilla (IBiS), HUVR/CSIC/Universidad de Sevilla/CIBERSAM, ISCIII, 41013, Sevilla, Spain, 41013., Grove J; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, 8210, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, 8000, Denmark.; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, 8000, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark, 8000., Børglum AD; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, 8210, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, 8000, Denmark.; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, 8000, Denmark., Martin H; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK., Baron-Cohen S; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK.; Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK., Bethlehem RAI; Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK., Warrier V; Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH.; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.; Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Apr 13. Date of Electronic Publication: 2024 Apr 13.