Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Maria Staub"'
Publikováno v:
Geological Society of America Abstracts with Programs.
Publikováno v:
Geological Society of America Abstracts with Programs.
Autor:
Gergely Keszler, Lynette D. Fairbanks, Maria Staub, R. Sumeg, Tatjana Spasokoukotskaja, A. Stenger, H. A. Simmonds
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 25:1133-1139
The widely used neuroleptic drug chlorpromazine (CPZ) influences membrane functions at the levels of ionic channels and receptors as shown. Here we show the effect of short term treatments by CPZ (30 microM), on the nucleotide-containing phospholipid
Autor:
Tatjana Spasokoukotskaja, Maria Staub, Staffan Eriksson, Gergely Keszler, Maria Sasvari-Szekely
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 25:1147-1151
The activity of deoxycytidine kinase (dCK) has been shown to be enhanced upon genotoxic stress in human lymphocytes, and reversible phosphorylation of the enzyme has been implicated in the activation process. Here, we provide compelling evidence that
Autor:
Gergely Keszler, Tatjana Spasokoukotskaja, Szula Virga, Pal I. Bauer, Maria Sasvari-Szekely, Maria Staub
Publikováno v:
Archives of Biochemistry and Biophysics. 436:69-77
The inborn deficiency of adenosine deaminase is characterised by accumulation of excess amounts of cytotoxic deoxyadenine nucleotides in lymphocytes. Formation of dATP requires phosphorylation of deoxyadenosine by deoxycytidine kinase (dCK), the main
Autor:
Gergely Keszler, Maria Staub, Iannis Talianidis, Tatjana Spasokoukotskaja, Maria Sasvari-Szekely, Zsolt Csapó, Staffan Eriksson
Publikováno v:
Biochemical Pharmacology. 67:947-955
Deoxycytidine kinase (dCK), the principal deoxynucleoside salvage enzyme, plays a seminal role in the bioactivation of a wide array of cytotoxic nucleoside analogues. Recently, activation of dCK has been considered as a protective cellular response t
Autor:
Gergely Keszler, Zsolt Csapó, Maria Staub, Géza Sáfrány, Tatjana Spasokoukotskaja, Maria Sasvari-Szekely, Iannis Talianidis
Publikováno v:
Biochemical Pharmacology. 65:2031-2039
Deoxycytidine kinase (dCK) is a key enzyme in the intracellular metabolism of deoxynucleosides and their analogues, phosphorylating a wide range of drugs used in the chemotherapy of leukaemia and solid tumours. Previously, we found that activity of d
Autor:
Zygmunt Kazimierczuk, Gergely Keszler, Maria Staub, Károly Szikla, Tatjana Spasokoukotskaja, Maria Sasvari-Szekely
Publikováno v:
Biochemical Pharmacology. 65:563-571
Deoxycytidine kinase (dCK) catalyses the rate-limiting step of the salvage of three natural deoxyribonucleosides as well as several therapeutic nucleoside analogues, which in turn can enhance its enzymatic activity [Biochem Pharmacol 56 (1998) 1175],
Publikováno v:
Molecular Genetics and Metabolism. 74:484-488
Decreased activity of plasma cholinesterase is responsible for prolonged apnea during anesthesia using neuromuscular blockers such as suxamethonium and mivacurium. More than 20 mutations have been identified so far in the BCHE gene resulting in impai
Autor:
Zsolt Ronai, Maria Sasvari-Szekely, András Guttman, Judit Gervai, Maria Staub, Csaba Barta, Krisztina Lakatos
Publikováno v:
ELECTROPHORESIS. 22:1102-1105
The -521C/Tsingle nucleotide polymorphism (SNP) in the promoter region of the dopamine D4 receptor gene (DRD4) has recently been detected in oriental (Japanese) individuals and related to novelty seeking and schizophrenia. Here, we report the analysi