Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Maria Spassova"'
Autor:
Robert S. Phillips, Kaljit Bhuller, Lillian Sung, Roland A. Ammann, Wim J.E. Tissing, Thomas Lehrnbecher, Lesley A. Stewart, Gabrielle M. Haeusler, Tiene Bauters, Geneviève Laureys, Maria Spassova, Robert Klaassen, Sarah Alexander, Pamela Silva, Juan Tordecilla, Marianne Paesmans, J. Peter Donnelly, Arne Simon, Ian M. Hann, Neil Ranasinghe, Richard D. Riley, Julia Chisholm, Daniel Yeomanson, Alex J. Sutton, Rachel Dommett, Ajay Gupta, Elio Castagnola, Ricarrdo Haupt, Karin Meidema, Thomas Kuehne, Lidija Kitanovski, Felix Niggli, David Nadal, Gulsun Tezcan, Hana Hakim, Glen Stryjewski
Publikováno v:
European Journal of Cancer, 64, 101-106. ELSEVIER SCI LTD
Background: Risk-stratified management of febrile neutropenia (FN) allows intensive management of high-risk cases and early discharge of low-risk cases. Most risk stratification systems predicting severe infection from admission variables have been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff28957d6e5d497a2fbc15d8ec26b28
https://doi.org/10.1016/j.ejca.2016.05.027
https://doi.org/10.1016/j.ejca.2016.05.027
Autor:
Jianglong Zhu, David R. Spriggs, Ouathek Ouerfelli, Maria Spassova, Sara Kravetz, Samuel J. Danishefsky, Svetlana Mironov, Roisin E. O'Cearbhaill, Paul Sabbatini, Alexia Iasonos, Govind Ragupathi, Qian Wan, Guangbin Yang
Publikováno v:
Cancers
Cancers, Vol 8, Iss 4, p 46 (2016)
Cancers; Volume 8; Issue 4; Pages: 46
Cancers, Vol 8, Iss 4, p 46 (2016)
Cancers; Volume 8; Issue 4; Pages: 46
We conducted a phase I study in ovarian cancer patients to evaluate the safety and immunogenicity of a synthetic unimolecular pentavalent carbohydrate vaccine (Globo-H, GM2, sTn, TF, and Tn) supported on a peptide backbone, conjugated to keyhole limp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c951a59e4afddf4b9e3323546505f3
https://pubmed.ncbi.nlm.nih.gov/27110823
https://pubmed.ncbi.nlm.nih.gov/27110823
Autor:
Samuel J. Danishefsky, Ouathek Ouerfelli, Payal Damani, Jianglong Zhu, Qian Wan, Guangbin Yang, Maria Spassova, Govind Ragupathi, Dongjoo Lee, Philip O. Livingston
Publikováno v:
Journal of the American Chemical Society. 131:9298-9303
A fully synthetic anticancer vaccine 2 has been prepared via bio-conjugation of unimolecular pentavalent construct 1 – containing five prostate and breast cancer associated carbohydrate antigens, Globo-H, GM2, STn, TF and Tn – to maleimide-modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b506092934cc51d702d1de116de853f
https://doi.org/10.1021/ja901415s
https://doi.org/10.1021/ja901415s
Autor:
Samuel J. Danishefsky, Atsushi Endo, Maria Spassova, Ouathek Ouerfelli, Qian Wan, Govind Ragupathi, Rebecca M. Wilson, Stacy J. Keding, Philip O. Livingston, Fusataka Koide, Jennifer D. Allen, Young Shin Cho
Publikováno v:
Journal of the American Chemical Society. 128:2715-2725
Several novel, fully synthetic, carbohydrate-based antitumor vaccines have been assembled. Each construct consists of multiple cancer-related antigens displayed on a single polypeptide backbone. Recent advances in synthetic methodology have allowed f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f98ec5e04cc6f0803c6415ca781e480
https://doi.org/10.1021/ja057244+
https://doi.org/10.1021/ja057244+
Autor:
Celso A. Reis, Matthew P. Jefferson, Philip O. Livingston, Andrew Wilton, Govind Ragupathi, Maria Spassova, Susan F. Slovin, Shemeeakah Powell, Samuel J. Danishefsky, Henrick Clausen, Howard I. Scher, Meghan Diani, Celina Fernandez
Publikováno v:
Vaccine. 23:3114-3122
GPI-0100 is a semi-synthetic saponin with modifications designed to augment stability and diminish toxicity. Two batches of GPI-0100 (the second with higher purity) were tested with doses ranging between 100 and 5000 microg in groups of five treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e1a43fc62ad964f069828a99af9155
https://doi.org/10.1016/j.vaccine.2005.01.072
https://doi.org/10.1016/j.vaccine.2005.01.072
Autor:
Govind Ragupathi, Natarajan Sathyan, Fusataka Koide, Maria Spassova, Polly D. Gregor, Celso A. Reis, Philip O. Livingston, Henrik Clausen, Samuel J. Danishefsky, Ella Kagan, William Bornmann
Publikováno v:
Cancer Immunology, Immunotherapy. 52:608-616
Previously using a series of monovalent vaccines, we demonstrated that the optimal method for inducing an antibody response against cancer cell-surface antigens is covalent conjugation of the antigens to keyhole limpet hemocyanin (KLH) and the use of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf7700a0c6936f3f1121130a3b3946b
https://doi.org/10.1007/s00262-003-0399-2
https://doi.org/10.1007/s00262-003-0399-2
Publikováno v:
The Journal of Physiology. 535:689-696
1. A semi-intact preparation of the chick basilar papilla was developed to study calcium-dependent neurotransmitter release by tall hair cells (avian equivalent of cochlear inner hair cells). 2. Tall hair cell depolarization resulted in changes in ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe85ac1fc1e1501a35deb0307fb2ed4
https://doi.org/10.1111/j.1469-7793.2001.00689.x
https://doi.org/10.1111/j.1469-7793.2001.00689.x
Autor:
Govindaswami Ragupathi, Lawrence J. Williams, Maria Spassova, Valery Kudryashov, William Bornmann, Susan F. Slovin, Xufang Zhang, Andrzej Zatorski, Howard I. Scher, Philip O. Livingston, Zhugang Wang, Kenneth O. Lloyd, Samuel J. Danishefsky
Publikováno v:
Proceedings of the National Academy of Sciences. 97:2719-2724
We have previously reported on a carbohydrate-based vaccine program for immunotherapy in cancer patients. One such vaccine, based on the globo H antigen conjugated to the protein keyhole limpet hemocyanin (KLH), has been in clinical evaluation. Altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f8e80ec867deb623ff95a5314c8a10
https://doi.org/10.1073/pnas.97.6.2719
https://doi.org/10.1073/pnas.97.6.2719
Autor:
John Curtin, Catherine O'Flaherty, Philip O. Livingston, Andrzej Zatorski, Maria Spassova, William G. Bornmann, Govindaswami Ragupathi, Paul Sabbatini, David Spriggs, Madeline Peyton, Valery Kudryashov, Carol Aghajanian, Kenneth O. Lloyd, Samuel J. Danishefsky, Steven L. Soignet
Publikováno v:
International Journal of Cancer. 87:79-85
As the initial step in developing carbohydrate-based vaccines for the treatment of ovarian cancer patients in an adjuvant setting, 25 patients were immunized with a Lewisy pentasaccharide (Ley)-keyhole limpet hemocyanin (KLH)-conjugate vaccine togeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46f6c79ccb7b3676fffe7e7eb7ad12aa
https://doi.org/10.1002/1097-0215(20000701)87:1<79::aid-ijc12>3.0.co
https://doi.org/10.1002/1097-0215(20000701)87:1<79::aid-ijc12>3.0.co
Autor:
Samuel J. Danishefsky, Hyunjin M. Kim, Sucharita Adluri, Govindaswami Ragupathi, Howard I. Scher, Kenneth O. Lloyd, Susan F. Slovin, William G. Bornmann, Philip O. Livingston, Maria Spassova, Dalibor Sames, In Jong Kim
Publikováno v:
Angewandte Chemie International Edition. 38:563-566
Human trials on the globo H carbohydrate vaccine (see picture, KLH=the carrier protein keyhole limpet hemocyanin) show that it produces strong IgM, and in some cases IgG, responses in patients with progressive and recurrent prostate cancer. Furthermo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0f405ecc6c9192b7085be8553a2c8d0
https://doi.org/10.1002/(sici)1521-3773(19990215)38:4<563::aid-anie563>3.0.co
https://doi.org/10.1002/(sici)1521-3773(19990215)38:4<563::aid-anie563>3.0.co