Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Maria Soledad Celej"'
Autor:
Nicholas G. James, David M. Jameson, Ernesto E. Ambroggio, Jose Ignacio Gallea, Maria Soledad Celej, Aldo Alejandro Vilcaes
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The amyloid aggregation of the presynaptic protein α-synuclein (AS) is pathognomonic of Parkinson's disease and other neurodegenerative disorders. Physiologically, AS contributes to synaptic homeostasis by participating in vesicle maintenance, traff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2338fa28a62958a4328d6247395ec0
Wiley Online Library
Wiley Online Library
Autor:
Ernesto R. Bongarzone, Marta B. Santos, Vadim Gaponenko, Giuseppe Scesa, Michael S. Marshall, Maria Soledad Celej, Richard B. van Breemen, Duc Nguyen, Jeffrey N. Marshall, Zane Hauck, Rachael A. Smith, Vince Elackattu, Monika Stoskute, Yazan Issa, Emily A. Rue, Hazem Abdelkarim
Publikováno v:
Scientific Reports
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports, Vol 8, Iss 1, Pp 1-19 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports, Vol 8, Iss 1, Pp 1-19 (2018)
Aggregation of α-synuclein, the hallmark of α-synucleinopathies such as Parkinson´s disease, occurs in various glycosphingolipidoses. Although α-synuclein aggregation correlates with deficiencies in the lysosomal degradation of glycosphingolipids
Autor:
Claudio Bussi, Ji M. Wang, Maria Soledad Celej, Yannick Schwab, Daniela S. Arroyo, Paolo Ronchi, Oliver Florey, Androniki Kolovou, Pablo Iribarren, Javier María Peralta Ramos, Jose Ignacio Gallea, Nicholas T. Ktistakis
Autophagy is a constitutive lysosomal catabolic pathway that degrades damaged organelles and protein aggregates. In Parkinson’s disease, the synaptic protein alpha-synuclein (AS) accumulates in neuronal cell bodies and axons. Recent studies indicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f5f58b75fea33338447f6d4a2bbebc
Autor:
Daniela S. Arroyo, Emilia A. Gaviglio, Ji Ming Wang, Javier María Peralta Ramos, Claudio Bussi, Jose Ignacio Gallea, Pablo Iribarren, Maria Soledad Celej
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports
Autophagy is a fundamental cellular homeostatic mechanism, whereby cells autodigest parts of their cytoplasm for removal or turnover. Neurodegenerative disorders are associated with autophagy dysregulation, and drugs modulating autophagy have been su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c715a5b8e20ab20b956cb9a0b61bc4
https://www.nature.com/articles/srep43153
https://www.nature.com/articles/srep43153
Autor:
Aurora Lopez-Rosas, Kumiko I. Claycomb, Maria I. Givogri, Richard B. van Breemen, Stephen J. Crocker, Maria Soledad Celej, Ludovico Cantuti-Castelvetri, Jose Ignacio Gallea, Marta B. Santos, Michael S. Marshall, Ernesto R. Bongarzone, Guannan Li, Benjamin Smith
Publikováno v:
The Journal of Pathology. 232:509-521
Demyelination is a major contributor to the general decay of neural functions in children with Krabbe disease. However, recent reports have indicated a significant involvement of neurons and axons in the neuropathology of the disease. In this study,
Autor:
Maria Soledad Celej, Vincent Raussens, Jose Ignacio Gallea, Adelin Gustot, Jean Marie Ruysschaert, Rabia Sarroukh
Publikováno v:
The Biochemical journal. 471(3)
Parkinson's disease (PD) is an age-related movement disorder characterized by a progressive degeneration of dopaminergic neurons in the midbrain. Although the presence of amyloid deposits of α-synuclein (α-syn) is the main pathological feature, PD
Publikováno v:
Protein Science. 12:1496-1506
The interaction between ligands and proteins usually induces changes in protein thermal stability with modifications in the midpoint denaturation temperature, enthalpy of unfolding, and heat capacity. These modifications are due to the coupling of un
Autor:
Rabia Sarroukh, Erik Goormaghtigh, Maria Soledad Celej, Vincent Raussens, Gerardo D. Fidelio, Jean Marie Ruysschaert
Publikováno v:
The Biochemical journal. 443(3)
Parkinson's disease is an age-related movement disorder characterized by the presence in the mid-brain of amyloid deposits of the 140-amino-acid protein AS (α-synuclein). AS fibrillation follows a nucleation polymerization pathway involving diverse
Autor:
Laura I. Rossi, Sergio Alberto Dassie, Martha Ines Burgos, Gerardo D. Fidelio, Ricardo Fernandez, Maria Soledad Celej
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Tetracycline (TC) derivatives are extensively used as antibiotics in human and animal medicine and, very recently, they have been screened as anti-amyloidogenic drugs. Anhydrotetracycline (AHTC) is one of the major degradation products of TC that has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b34b73aeec025e649fc71bbcb19bb5
https://www.ncbi.nlm.nih.gov/pubmed/21804222
https://www.ncbi.nlm.nih.gov/pubmed/21804222
Publikováno v:
Journal of Chemical Education. 82:85
The aim of this work is to present the physicochemical basis underlying the changes in protein thermostability upon ligand binding. The article is addressed to advanced undergraduate and postgraduate chemistry students with an interest in protein bio