Lipoic Acid as a Possible Pharmacological Source of Hydrogen Sulfide/Sulfane Sulfur

Autor: Anna Bilska-Wilkosz, Małgorzata Iciek, Danuta Kowalczyk-Pachel, Magdalena Górny, Maria Sokołowska-Jeżewicz, Lidia Włodek

Publikováno v: Molecules, Vol 22, Iss 3, p 388 (2017)

The aim of the present study was to verify whether lipoic acid (LA) itself is a source of H2S and sulfane sulfur. It was investigated in vitro non-enzymatically and enzymatically (in the presence of rat tissue homogenate). The results indicate that b

Externí odkaz: https://doaj.org/article/a5ab7f9294a04f1fbf4fc7b2d24933b7

Lipoic Acid as a Possible Pharmacological Source of Hydrogen Sulfide/Sulfane Sulfur

Autor: Małgorzata Iciek, Maria Sokołowska-Jeżewicz, Anna Bilska-Wilkosz, Magdalena Górny, Lidia Włodek, Danuta Kowalczyk-Pachel

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 22, Iss 3, p 388 (2017)
Molecules; Volume 22; Issue 3; Pages: 388

The aim of the present study was to verify whether lipoic acid (LA) itself is a source of H2S and sulfane sulfur. It was investigated in vitro non-enzymatically and enzymatically (in the presence of rat tissue homogenate). The results indicate that b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be2650e4af1c235938b3440f862e0c7
https://ruj.uj.edu.pl/xmlui/handle/item/120520

The effect of uremic toxin cyanate (OCN--) on anaerobic sulfur metabolism and prooxidative processes in the rat kidney: A protective role of lipoate

Autor: Elżbieta Lorenc-Koci, Małgorzata Iciek, Maria Sokołowska, Lidia Włodek, Anna Bilska

Publikováno v: Human & Experimental Toxicology. 30:1601-1608

Cyanate and its active form isocyanate are formed mainly in the process of nonenzymatic urea biodegradation. Cyanate is capable of protein S- and N-carbamoylation, which can affect their activity. The present studies aimed to demonstrate the effect o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792961bfee8e379aa1285aed6f0b010b
https://doi.org/10.1177/0960327110394225

Alpha-lipoic acid differently affects the reserpine-induced oxidative stress in the striatum and prefrontal cortex of rat brain

Autor: Lidia Włodek, M. Dubiel, Anna Bilska, Maria Sokołowska-Jeżewicz, Elżbieta Lorenc-Koci

Publikováno v: Neuroscience. 146:1758-1771

Antioxidative properties of alpha-lipoic acid (LA) are widely investigated in different in vivo and in vitro models. The aim of this study was to examine whether LA attenuates oxidative stress induced in rats by reserpine, a model substance frequentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becfad178912f758d93b54cbf263b9fe
https://doi.org/10.1016/j.neuroscience.2007.04.002

Activation of DNA biosynthesis in human hepatoblastoma HEPG2 cells by the nitric oxide donor, sodium nitroprusside

Autor: Maria Sokołowska, Hanna Rokita, Lidia Włodek

Publikováno v: Fundamental and Clinical Pharmacology. 17:599-607

The role of nitric oxide (NO) in carcinogenesis is controversial as it has been shown to both stimulate and inhibit tumour growth. Also, there are contradictory opinions regarding the effects of NO on the proliferation of normal and tumour cells. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2722992b24d1b1cdbdeb67dd15e8a8ec
https://doi.org/10.1046/j.1472-8206.2003.00182.x