Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maria Skamagki"'
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2058-2065 (2017)
We discovered that induced pluripotent stem cell (iPSC) clones generated from aged tissue donors (A-iPSCs) fail to suppress oxidative phosphorylation. Compared to embryonic stem cells (ESCs) and iPSCs generated from young donors (Y-iPSCs), A-iPSCs sh
Externí odkaz:
https://doaj.org/article/15e2eb6501bd40bebf221e3382549911
Autor:
Zhong Liu, Cheng Zhang, Maria Skamagki, Alireza Khodadadi-Jamayran, Wei Zhang, Dexin Kong, Chia-Wei Chang, Jingyang Feng, Xiaosi Han, Tim M. Townes, Hu Li, Kitai Kim, Rui Zhao
Publikováno v:
Stem Cell Reports, Vol 9, Iss 5, Pp 1604-1617 (2017)
Summary: Pluripotent stem cells (PSCs) deficient for microRNAs (miRNAs), such as Dgcr8−/− or Dicer−/– embryonic stem cells (ESCs), contain no mature miRNA and cannot differentiate into somatic cells. How miRNA deficiency causes differentiatio
Externí odkaz:
https://doaj.org/article/fe69fd9c1cce436280476766fcc5a2a9
Autor:
Maria Skamagki, Cheng Zhang, Christian A. Ross, Aparna Ananthanarayanan, Zhong Liu, Quanhua Mu, Uttiya Basu, Jiguang Wang, Rui Zhao, Hu Li, Kitai Kim
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1053-1061 (2017)
The RNA exosome complex targets AU-rich element (ARE)-containing mRNAs in eukaryotic cells. We identified a transcription factor, ZSCAN10, which binds to the promoters of multiple RNA exosome complex subunits in pluripotent stem cells to maintain sub
Externí odkaz:
https://doaj.org/article/736cc3edd1f8461ba96aa1b7a542faf5
Publikováno v:
Stem Cell Reports, Vol 5, Iss 6, Pp 1119-1127 (2015)
MicroRNAs (miRNAs) are important regulators of reprogramming of somatic cells into induced pluripotent stem cells (iPSCs); however, it is unclear whether miRNAs are required for reprogramming and whether miRNA activity as a whole facilitates reprogra
Externí odkaz:
https://doaj.org/article/56950cb8cd614613ac1ca45fc5d3cd22
Autor:
Maria Skamagki, Krzysztof B. Wicher, Agnieszka Jedrusik, Sujoy Ganguly, Magdalena Zernicka-Goetz
Publikováno v:
Cell Reports, Vol 3, Iss 2, Pp 442-457 (2013)
A longstanding question in mammalian development is whether the divisions that segregate pluripotent progenitor cells for the future embryo from cells that differentiate into extraembryonic structures are asymmetric in cell-fate instructions. The tra
Externí odkaz:
https://doaj.org/article/26990be68366419b91e6505505c851ac
Publikováno v:
Cancer Research. 83:5990-5990
Objective: CDK4/6 inhibition has become an important treatment option in some epithelial malignancies but its utility in the setting of NSCLC remains limited. While CDK4-based monotherapy has been generally ineffective, combinatorial regimens have sh
Autor:
Christian A. Ross, Hu Li, Zhong Liu, Uttiya Basu, Maria Skamagki, Kitai Kim, Aparna Ananthanarayanan, Quanhua Mu, Jiguang Wang, Rui Zhao, Cheng Zhang
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 9, Iss 4, Pp 1053-1061 (2017)
Stem Cell Reports, Vol 9, Iss 4, Pp 1053-1061 (2017)
Summary The RNA exosome complex targets AU-rich element (ARE)-containing mRNAs in eukaryotic cells. We identified a transcription factor, ZSCAN10, which binds to the promoters of multiple RNA exosome complex subunits in pluripotent stem cells to main
Autor:
Christian A. Ross, James Adjaye, Percy Yeung, Maria Skamagki, Hironori Funabiki, Hu Li, Lam Dang, Rui Zhao, Samuel Beck, Kitai Kim, Simona Giunta, Jonghwan Kim, Timour Baslan, Cristina Correia, James J. Collins, Aparna Ananthanarayanan, Chi Wei Lu, Cheng Zhang, Scott W. Lowe, Zhong Liu, Martina Bohndorf, Joye Wang, Tzu-Pei Chang, Benedikt Bosbach
Publikováno v:
Nature Cell Biology. 19:1037-1048
Induced pluripotent stem cells (iPSCs), which are used to produce transplantable tissues, may particularly benefit older patients, who are more likely to suffer from degenerative diseases. However, iPSCs generated from aged donors (A-iPSCs) exhibit h
Publikováno v:
Cell Reprogram
Autor:
James J. Collins, Christian A. Ross, James Adjaye, Cristina Correia, Aparna Ananthanarayanan, Lam Dang, Maria Skamagki, Scott W. Lowe, Simona Giunta, Percy Yeung, Hironori Funabiki, Samuel Beck, Kitai Kim, Hu Li, Tzu-Pei Chang, Benedikt Bosbach, Timour Baslan, Rui Zhao, Chi Wei Lu, Jonghwan Kim, Cheng Zhang, Zhong Liu, Martina Bohndorf, Joye Wang
Publikováno v:
Nature Cell Biology. 21:531-532
In the version of this Article originally published, Supplementary Fig. 6j showed incorrect values for the LS and AG4 glutathione samples, and Fig. 5c and Supplementary Fig. 6j did not include all n = 6 samples for the hESC, Y-hiPSC and AG4-ZSCAN10 g