Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Maria Sibilia"'
Autor:
Cristiano De Sá Fernandes, Philipp Novoszel, Tommaso Gastaldi, Dana Krauß, Magdalena Lang, Ramona Rica, Ana P. Kutschat, Martin Holcmann, Wilfried Ellmeier, Davide Seruggia, Herbert Strobl, Maria Sibilia
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114308- (2024)
Summary: Dendritic cell (DC) progenitors adapt their transcriptional program during development, generating different subsets. How chromatin modifications modulate these processes is unclear. Here, we investigate the impact of histone deacetylation o
Externí odkaz:
https://doaj.org/article/6c8fa45f010148acacb631b83f74b7ac
Autor:
Barizah Malik, Iva Vokic, Thomas Mohr, Marle Poppelaars, Martin Holcmann, Philipp Novoszel, Gerald Timelthaler, Thomas Lendl, Dana Krauss, Ulrich Elling, Michael Mildner, Josef M Penninger, Peter Petzelbauer, Maria Sibilia, Agnes Csiszar
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 7, Pp n/a-n/a (2023)
Abstract FAM3C/ILEI is an important cytokine for tumor progression and metastasis. However, its involvement in inflammation remains elusive. Here, we show that ILEI protein is highly expressed in psoriatic lesions. Inducible keratinocyte‐specific I
Externí odkaz:
https://doaj.org/article/652d23ea03604539be44368f1962df2d
Autor:
Ulrike Schmidt, Betül Uluca, Iva Vokic, Barizah Malik, Thomas Kolbe, Caroline Lassnig, Martin Holcmann, Veronica Moreno-Viedma, Bernhard Robl, Carina Mühlberger, Dagmar Gotthardt, Maria Sibilia, Thomas Rülicke, Mathias Müller, Agnes Csiszar
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0286256 (2023)
FAM3C/ILEI is an important factor in epithelial-to-mesenchymal transition (EMT) induction, tumor progression and metastasis. Overexpressed in many cancers, elevated ILEI levels and secretion correlate with poor patient survival. Although ILEI's causa
Externí odkaz:
https://doaj.org/article/994b8dfe26b74aa0b5ce6ad114d089ef
Autor:
Stefan Moritsch, Bernadette Mödl, Irene Scharf, Lukas Janker, Daniela Zwolanek, Gerald Timelthaler, Emilio Casanova, Maria Sibilia, Thomas Mohr, Lukas Kenner, Dietmar Herndler-Brandstetter, Christopher Gerner, Mathias Müller, Birgit Strobl, Robert Eferl
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Janus kinase Tyk2 is implicated in cancer immune surveillance, but its role in solid tumors is not well defined. We used Tyk2 knockout mice (Tyk2Δ/Δ) and mice with conditional deletion of Tyk2 in hematopoietic (Tyk2ΔHem) or intestinal epithelial c
Externí odkaz:
https://doaj.org/article/ec4f1b9c22f84cf89d8018da851833f7
Autor:
Ulrike Schmidt, Gerwin Heller, Gerald Timelthaler, Petra Heffeter, Zsolt Somodi, Norbert Schweifer, Maria Sibilia, Walter Berger, Agnes Csiszar
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-21 (2021)
Abstract Background Gene amplification of MET, which encodes for the receptor tyrosine kinase c-MET, occurs in a variety of human cancers. High c-MET levels often correlate with poor cancer prognosis. Interleukin-like EMT inducer (ILEI) is also overe
Externí odkaz:
https://doaj.org/article/3fb71a0b63bd4e22a31d76f2d1a78286
Autor:
Vera Belyaeva, Stephanie Wachner, Attila Gyoergy, Shamsi Emtenani, Igor Gridchyn, Maria Akhmanova, Markus Linder, Marko Roblek, Maria Sibilia, Daria Siekhaus
Publikováno v:
PLoS Biology, Vol 20, Iss 1, p e3001494 (2022)
The infiltration of immune cells into tissues underlies the establishment of tissue-resident macrophages and responses to infections and tumors. Yet the mechanisms immune cells utilize to negotiate tissue barriers in living organisms are not well und
Externí odkaz:
https://doaj.org/article/d00742cb5c804860a3e34bce11e7bde5
Autor:
Sandra Grund‐Gröschke, Daniela Ortner, Antal B. Szenes‐Nagy, Nadja Zaborsky, Richard Weiss, Daniel Neureiter, Martin Wipplinger, Angela Risch, Peter Hammerl, Richard Greil, Maria Sibilia, Iris K. Gratz, Patrizia Stoitzner, Fritz Aberger
Publikováno v:
Molecular Oncology, Vol 14, Iss 9, Pp 1930-1946 (2020)
Genetic activation of hedgehog/glioma‐associated oncogene homolog (HH/GLI) signaling causes basal cell carcinoma (BCC), a very frequent nonmelanoma skin cancer. Small molecule targeting of the essential HH effector Smoothened (SMO) has proven an ef
Externí odkaz:
https://doaj.org/article/010906a9f19b493eb18dbcddbbcc7354
Autor:
Caterina Barresi, Heidemarie Rossiter, Maria Buchberger, Johannes Pammer, Supawadee Sukseree, Maria Sibilia, Erwin Tschachler, Leopold Eckhart
Publikováno v:
Cells, Vol 11, Iss 22, p 3691 (2022)
Autophagy is a ubiquitous degradation mechanism, which plays a critical role in cellular homeostasis. To test whether autophagy suppresses or supports the growth of tumors in the epidermis of the skin, we inactivated the essential autophagy gene Atg7
Externí odkaz:
https://doaj.org/article/8dafe93792c34854ab5c620f0e925636
Autor:
Philipp Novoszel, Martin Holcmann, Gabriel Stulnig, Cristiano De Sa Fernandes, Victoria Zyulina, Izabela Borek, Markus Linder, Alexandra Bogusch, Barbara Drobits, Thomas Bauer, Carmen Tam‐Amersdorfer, Patrick M Brunner, Georg Stary, Latifa Bakiri, Erwin F Wagner, Herbert Strobl, Maria Sibilia
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp n/a-n/a (2021)
Abstract Toll‐like receptor (TLR) stimulation induces innate immune responses involved in many inflammatory disorders including psoriasis. Although activation of the AP‐1 transcription factor complex is common in TLR signaling, the specific invol
Externí odkaz:
https://doaj.org/article/142744ca6c4549809415e7ef066cebb0
Autor:
Nicole Amberg, Panagiota A. Sotiropoulou, Gerwin Heller, Beate M. Lichtenberger, Martin Holcmann, Bahar Camurdanoglu, Temenuschka Baykuscheva-Gentscheva, Cedric Blanpain, Maria Sibilia
Publikováno v:
iScience, Vol 15, Iss , Pp 243-256 (2019)
Summary: Epidermal growth factor receptor (EGFR) signaling controls skin development and homeostasis in mice and humans, and its deficiency causes severe skin inflammation, which might affect epidermal stem cell behavior. Here, we describe the inflam
Externí odkaz:
https://doaj.org/article/fec4df02adcd448198444c8a11fb38f7