Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Maria Shellock"'
Autor:
Lauren Scarpetti, Chetan C Oturkar, Dejan Juric, Maria Shellock, Giuliana Malvarosa, Kathryn Post, Steven Isakoff, Nancy Wang, Brian Nahed, Kevin Oh, Gokul M Das, Aditya Bardia
Publikováno v:
The Oncologist. 28:358-363
The absence of effective therapeutic targets and aggressive nature of triple-negative breast cancer (TNBC) renders this disease subset difficult to treat. Although estrogen receptor beta (ERβ) is expressed in TNBC, studies on its functional role hav
Autor:
Aditya Bardia, James T. Coates, Laura Spring, Sheng Sun, Dejan Juric, Nayana Thimmiah, Andrzej Niemierko, Phoebe Ryan, Ann Partridge, Jeffrey Peppercorn, Heather Parsons, Seth Wander, Kelsey Pierce, Victoria Attaya, Donna Fitzgerald, Brenda Lormil, Maria Shellock, Aiko Nagayama, Veerle Bossuyt, Bev Moy, Sara Tolaney, Leif Ellisen
Publikováno v:
Cancer Research. 82:2638-2638
Background: Sacituzumab Govitecan (SG), the first antibody-drug conjugate approved for metastatic TNBC (mTNBC), is comprised of SN-38 (active metabolite of irinotecan), a topoisomerase I (TOP1) inhibitor, coupled via a hydrolyzable linker to monoclon
Autor:
Jennifer A. Chan, Lawrence S. Blaszkowsky, Kimmie Ng, Charles S. Fuchs, Pankaj Bhargava, Maria Shellock, Jill N. Allen, Jeffrey A. Meyerhardt, Brian M. Wolpin, Andrew X. Zhu, Nadine Jackson McCleary, Eunice L. Kwak, Peter C. Enzinger, Meaghan Elliott, Wolfram Goessling, Deborah Schrag, Thomas A. Abrams, Eileen Regan
Publikováno v:
Journal of Clinical Oncology. 30:560-560
560 Background: Everolimus (E) is an oral inhibitor of mTOR. Tivozanib (T) is a highly potent, selective, oral inhibitor of VEGF receptors-1, -2, and -3. Preclinical data suggest antitumor activity for this combination in colorectal cancer. We theref