Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Maria Scuotto"'
Autor:
Elisa Rivieccio, Marialuisa Menna, Concetta Imperatore, Annapina Russo, Carlo Altucci, Michela Varra, Luciano Mayol, Giulia Russo, Anna Ramunno, Mohammadhassan Valadan, Assunta Saide, Maria Scuotto
In order to expand the class of diazocompounds able to act as photo-activable microtubule inhibitors the potential of azo-heteroarenes has been explored. In this paper we focus on the synthesis, physical properties and biological effects of methyl ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e61707538a731b97388e9b2206de696
http://hdl.handle.net/11386/4723994
http://hdl.handle.net/11386/4723994
Autor:
Antonella Virgilio, Luciano Mayol, Luciana Tartaglione, Veronica Esposito, Michela Varra, Mamuka Kvaratskhelia, Maria Scuotto, Pratibha C. Koneru, Elisa Rivieccio, Carmela Dell'Aversano
Publikováno v:
Biochimica et biophysica acta. General subjects. 1863(2)
Some G-quadruplex (GQ) forming aptamers, such as T30695, exhibit particularly promising properties among the potential anti-HIV drugs. T30695 G-quadruplex binds to HIV-1 integrase (IN) and inhibits its activity during 3′-end processing at nanomolar
Autor:
Mohammadhassan Valadan, Concetta Imperatore, Maria Scuotto, Carlo Altucci, Marialuisa Menna, Michela Varra
The trans-to-cis photo-isomerization of azobenzene (AzB) and its derivatives (AzDs) is a well known process (1), that, in the course of the last two decades has been studied extensively for its high potential in a wide range of technological applicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::313b6269e531685c9853d7a8591e9383
http://hdl.handle.net/11588/738140
http://hdl.handle.net/11588/738140
Autor:
Maria Scuotto, Marco Persico, Concetta Imperatore, Valentina Vellecco, Elena Morelli, Mariarosaria Bucci, Marialuisa Menna, Caterina Fattorusso, Michela Varra
The thrombin binding aptamer (TBA) is a 15-mer oligonucleotide (ON) which folds into a typical chair-like G-quadruplex structure containing one TGT and two TT loops.(1) It binds thrombin acting as an anticoagulant agent.(2) In our ongoing investigati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::b6d697dbd4d1b58477be75e5c61a4bed
http://hdl.handle.net/11588/738137
http://hdl.handle.net/11588/738137
Autor:
Concetta Imperatore, Maria Scuotto, Antonio Varriale, Maria Staiano, Sabato D'Auria, Elisa Rivieccio, Marialuisa Menna, Michela Varra
The synthesis and the structural characterization of azobenzene-conjugated GQs were formed. Firstly, we synthesized the R 4-(dimethylamino)azobenzene glycerol derivative (4-DMAzo). Trans-cis photo-isomerisation of 4-DMAzo can be induced by violet lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::2a0041bc048779e606c3729112e9b0e4
http://hdl.handle.net/11588/738144
http://hdl.handle.net/11588/738144
Autor:
Antonella Virgilio, Elisa Rivieccio, Aldo Galeone, Veronica Esposito, Daniela Corda, Giuseppe Cirino, Michela Varra, Mariarosaria Bucci, Nicola Borbone, Valentina Vellecco, Luciano Mayol, Alessia Varone, Maria Scuotto
Publikováno v:
Nucleic acids research (Online) 43 (2015): 7702–7716. doi:10.1093/nar/gkv789
info:cnr-pdr/source/autori:Scuotto M.; Rivieccio E.; Varone A.; Corda D.; Bucci M.; Vellecco V.; Cirino G.; Virgilio A.; Esposito V.; Galeone A.; Borbone N.; Varra M.; Mayol L./titolo:Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative/doi:10.1093%2Fnar%2Fgkv789/rivista:Nucleic acids research (Online)/anno:2015/pagina_da:7702/pagina_a:7716/intervallo_pagine:7702–7716/volume:43
Nucleic Acids Research
info:cnr-pdr/source/autori:Scuotto M.; Rivieccio E.; Varone A.; Corda D.; Bucci M.; Vellecco V.; Cirino G.; Virgilio A.; Esposito V.; Galeone A.; Borbone N.; Varra M.; Mayol L./titolo:Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative/doi:10.1093%2Fnar%2Fgkv789/rivista:Nucleic acids research (Online)/anno:2015/pagina_da:7702/pagina_a:7716/intervallo_pagine:7702–7716/volume:43
Nucleic Acids Research
Many antiproliferative G-quadruplexes (G4s) arise from the folding of GT-rich strands. Among these, the Thrombin Binding Aptamer (TBA), as a rare example, adopts a monomolecular well-defined G4 structure. Nevertheless, the potential anticancer proper
Autor:
Mario De Rosa, Veronika Temml, Hermann Stuppner, Chiara Schiraldi, Maria Scuotto, Antonietta Rossi, Oliver Werz, Antonella Peduto, Fiorentina Roviezzo, Daniela Schuster, Bruno D'Agostino, Rosanna Filosa, Verena Krauth, Veronica Esposito
Aiming to assess the biological activities of synthetic 1,4-benzoquinones, we previously synthesized different libraries of benzoquinones with lipophilic and bulky alkyl- or aryl-substituents that inhibited 5-lipoxygenase (5-LO). The high potency of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265b17f0ab93aecb4f22b6ddbba31e69
http://hdl.handle.net/11588/652417
http://hdl.handle.net/11588/652417
Autor:
Rita Santamaria, Antonella Virgilio, Aldo Galeone, Michela Varra, Antonella Capuozzo, Luciano Mayol, Veronica Esposito, Maria Scuotto
Publikováno v:
Org. Biomol. Chem.. 12:8840-8843
Degradation of nucleic acids in biological environments is the major drawback of the therapeutic use of aptamers. Among the approaches used to circumvent this negative aspect, the introduction of 3'-3' inversion of polarity sites at the sequence 3'-e
Autor:
Mariarosaria Bucci, Giuseppe Cirino, Michela Varra, Jussara Amato, Stefano D'Errico, Maria Scuotto, Caterina Fattorusso, Valentina D'Atri, Gennaro Piccialli, Elena Morelli, Marco Persico, Valentina Vellecco, Nicola Borbone, Luciano Mayol, Giorgia Oliviero
Publikováno v:
Journal of Medicinal Chemistry. 55:10716-10728
An acyclic pyrimidine analogue, containing a five member cycle fused on the pyrimidine ring, was synthesized and introduced at position 7 or 12 of the 15-mer oligodeoxynucleotide GGTTGGTGTGGTTGG, known as Thrombin Binding Aptamer (TBA). Characterizat
Autor:
Luigi Petraccone, Veronica Esposito, Mariarosaria Bucci, Antonella Virgilio, Michela Varra, Aldo Galeone, Valentina Vellecco, Luciano Mayol, Maria Scuotto
In this article we report an investigation concerning analogues of the thrombin binding aptamer (TBA) in which thymidines have been replaced, one at a time, by the unusual residue 5-hydroxymethyl-2'-deoxyuridine (hmU) that differs from the canonical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b07d07a85820b9a40ffc2631bbe694d
http://hdl.handle.net/11588/585384
http://hdl.handle.net/11588/585384